基本信息

朱昱敏，女，2015年6月于南京大學獲學士學位，2020年6月于清華大學獲博士學位。

研究方向

多組學與生物信息學，關注母嬰健康、血管疾病等領域。

1.疾病生物标志物鑒定及風險預測模型開發

結合隊列研究、生物信息學算法、分子生物學實驗和人工智能模型，鑒定可用于疾病早期診斷或預後監測的生物标志物，并構建精準預測智能模型。

2.醫學大數據整合研究及基因調控網絡構建

整合多組學等生物醫學大數據，從表觀遺傳、轉錄調控、轉錄後調控、翻譯調控等多層面描繪疾病發生發展過程中的基因調控圖譜，揭示靶标基因。

成果簡介

主持國家級、省部級、校級科研項目6項，作為項目骨幹參與國家級科研項目多項；在Cell Research、Nucleic Acids Research等國内外重要學術期刊上發表學術論文20餘篇；申請國家發明專利3項，已授權1項。指導本科生獲得國家級大學生創新訓練項目1項、省級大學生創新訓練項目1項，南京大學安邦書院“金種子”早期科研訓練項目1項，并在多項教學競賽中獲得優異成績。

1. Ren, J., Wang, Y., Zhang, Y., Jin, H., Cheng, J., Tao, F., & Zhu, Y. (2024). Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on Neurodevelopment in Children. Environmental science & technology,58(43), 19141–19151.

2. Jin, H., Wang, X., Li, L., Rui, C., Gan, H., Wang, Q., Tao, F., & Zhu, Y. (2024). Integrated proteomic and transcriptomic landscape of human placenta in small for gestational age infants. iScience, 27, 111423.

3. Zhu, Y., Zhang, Y., Jin, Y., Jin, H., Huang, K., Tong, J., Gan, H., Rui, C., Lv, J., Wang, X., Wang, Q., & Tao, F. (2023). Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children. BMC medicine, 21(1), 326.

4. Jin, H., Zhang, Y., Fan, Z., Wang, X., Rui, C., Xing, S., Dong, H., Wang, Q., Tao, F., & Zhu, Y. (2023). Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles. Journal of translational medicine, 21(1), 256.

5. Xing, S., Zhu, Y., You, Y., Wang, S., Wang, H., Ning, M., Jin, H., Liu, Z., Zhang, X., Yu, C., & Lu, Z. J. (2023). Cell-free RNA for the liquid biopsy of gastrointestinal cancer. Wiley interdisciplinary reviews. RNA, 14(5), e1791.

6. Ren, J., Jin, H., & Zhu, Y. (2023). The Role of Placental Non-Coding RNAs in Adverse Pregnancy Outcomes. International journal of molecular sciences, 24(5), 5030.

7. Yao, Y., Liu, K., Wu, Y., Zhou, J., Jin, H., Zhang, Y., & Zhu, Y. (2022). Comprehensive landscape of the functions and prognostic value of RNA binding proteins in uterine corpus endometrial carcinoma. Frontiers in molecular biosciences, 9, 962412.

8. Zhu, Y., Wang, S., Xi, X., Zhang, M., Liu, X., Tang, W., Cai, P., Xing, S., Bao, P., Jin, Y., Zhao, W., Chen, Y., Zhao, H., Jia, X., Lu, S., Lu, Y., Chen, L., Yin, J., & Lu, Z. J. (2021). Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer. Theranostics, 11(1), 181-193.

9. Zhu, Y., Xu, G., Yang, Y. T., Xu, Z., Chen, X., Shi, B., Xie, D., Lu, Z. J., & Wang, P. (2019). POSTAR2: deciphering the post-transcriptional regulatory logics. Nucleic acids research, 47(D1), D203-D211.

10. Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023). LilrB3 is a putative cell surface receptor of APOE4. Cell research, 33(2), 116-130.

11. Tao, Y., Xing, S., Zuo, S., Bao, P., Jin, Y., Li, Y., Li, M., Wu, Y., Chen, S., Wang, X., Zhu, Y., Feng, Y., Zhang, X., Wang, X., Xi, Q., Lu, Q., Wang, P., & Lu, Z. J. (2023). Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients' blood. Cell reports. Medicine, 4(11), 101281.

12. Wang, Z., Zheng, Z., Zhu, Y., Kong, S., & Liu, D. (2023). PHOSPHATE RESPONSE 1 family members act distinctly to regulate transcriptional responses to phosphate starvation. Plant physiology, 191(2), 1324–1343.

13. Huang, B., Zhao, W., Cai, X., Zhu, Y., Lu, Y., Zhao, J., Xiang, N., Wang, X., Deng, H., Tang, X., Liu, L., Zhao, Y., & Shi, Y. (2023). Expression and Activity of the Transcription Factor CCAAT/Enhancer-Binding Protein β (C/EBPβ) Is Regulated by Specific Pulse-Modulated Radio Frequencies in Oligodendroglial Cells. International journal of molecular sciences, 24(13), 11131.

14. Zhao, W., Zhang, S., Zhu, Y., Xi, X., Bao, P., Ma, Z., Kapral, T. H., Chen, S., Zagrovic, B., Yang, Y. T., & Lu, Z. J. (2022). POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. Nucleic acids research, 50(D1), D287–D294.

15. Tong, J., Liang, C., Wu, X., Huang, K., Zhu, B., Gao, H., Zhu, Y., Li, Z., Qi, J., Han, Y., Ding, P., Zhu, Y., & Tao, F. (2022). Prenatal serum thallium exposure and cognitive development among preschool-aged children: A prospective cohort study in China. Environmental pollution (Barking, Essex : 1987), 293, 118545.

16. Tan, C., Cao, J., Chen, L., Xi, X., Wang, S., Zhu, Y., Yang, L., Ma, L., Wang, D., Yin, J., Zhang, T., & John Lu, Z. (2019). Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma. Clinical chemistry, 65(7), 905–915.

17. Yuan, J., Li, J., Yang, Y., Tan, C., Zhu, Y., Hu, L., Qi, Y., & Lu, Z. J. (2018). Stress-responsive regulation of long non-coding RNA polyadenylation in Oryza sativa. The Plant journal : for cell and molecular biology, 93(5), 814–827.

18. Hu, B., Yang, Y. T., Huang, Y., Zhu, Y., & Lu, Z. J. (2017). POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. Nucleic acids research, 45(D1), D104–D114.

19. Xi, X., Li, T., Huang, Y., Sun, J., Zhu, Y., Yang, Y., & Lu, Z. J. (2017). RNA Biomarkers: Frontier of Precision Medicine for Cancer. Non-coding RNA, 3(1), 9.

20. 朱昱敏，劉吉梓，周遊，王方旭，潘鳴飛，張方舟，曹晨，沈豔，顧甯. 細胞生物信息學應用于疾病診斷的前景. 2023，v.40 (04) 533-542.

主持

中央高校基本科研業務費——AI&AI for Science青年項目

國家自然科學基金青年項目

安徽省自然科學基金青年項目

安徽省轉化醫學研究院重點項目

參與

國家自然科學基金區域創新聯合基金

國家自然科學基金面上項目

2015，南京大學優秀畢業生

2018，博士研究生國家獎學金

2021，課程創新創業教學競賽校賽二等獎

2022，第二屆全國高校教師教學創新大賽校賽二等獎