 趙越博士
研究員/助理教授/博導
電話：郵箱：zhyue@nju.edu.cn 地址：南京大學鼓樓校區伟德官网手机版基礎醫學研究中心研究方向：
脂肪組織重塑與代謝性疾病 助理教授、博導，江蘇省“優秀青年”基金獲得者。曾獲得中國細胞生物學會未來女科學計劃提名、中國免疫學會第十一屆青年學者獎提名。 研究方向：1）2型糖尿病和肥胖演進的時空網絡調控，2）脂肪組織的免疫代謝調節，3）基于工程化真菌的産熱脂肪活化。緻力于針對糖尿病分期分型及并發症的新型AI診療體系研發與機制探讨，并建立了“臨床表征AI圖像識别—糞便代謝物—腸道共生菌—免疫微環境”的全鍊條研究體系。 研究成果：發表SCI論文20餘篇，以第一作者或通訊作者在Nat Commun.、Clin and Tran Med、Int J Biol Sci、J Pathol.、J Biol Chem.等期刊等國際高水平學術期刊發表論文10餘篇；申請國内外發明專利4項，授權2項，PCT國際專利授權1項。主持國家自然科學基金專項項目、面上項目、青年基金項目、中國博士後基金各1項，主持江蘇省自然科學優秀青年基金和青年基金各1項，作為課題骨幹參與國家重點研發計劃重點專項1項，重大研究計劃1項，負責省市級課題多項。 教學工作：主持面向本科生、研究生等多個專業課程；參與校級各類教學改革項目；曾獲南京大學教師教學競賽優秀獎等多個獎項；指導本科生榮獲全國大學生基礎醫學創新論壇全國賽區金獎（1次）、銀獎（1次），華東賽區一等獎（2次）。 中國生物物理學會代謝生物學分會青年理事 江蘇省免疫學會青年工作委員會常委兼秘書長 江蘇省免疫學會免疫與代謝專委會常委 江蘇省醫學會整合醫學研究會常委 Frontiers in Endocrinology、Medcomm等期刊審稿專家 1、Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang*, Xi-Tai Sun*, Bin Xue*, Chao-Jun Li*. Liver Governs Adipose Remodelling via Extracellular Vesicles in Response to Lipid Overload. Nat Commun. 2020;11(1):719. (IF=16.6) 2、Baochao Li, Yuqin Jin, Bingqing Zhang, Tong Lu, Jialing Li, Jingzi Zhang, Yiwen Zhou, Yanyi Wang, Caixia Zhang, Yue Zhao*, Huang Li*. Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity. Clin. Transl. Med. 2024;14:e70029. 3、Yue Zhao, Tian-Yu Wu, Meng-Fei Zhao, and Chao-Jun Li*. The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease. J Biol Chem. 2020 Apr 10;295(15):5152-5162. 4、Yue Zhao#,*, Meng-Fei Zhao#, Mei-Lin Yang#, Tian-Yu Wu, Cong-Jian Xu, Jing-Mei Wang, Chao-Jun Li*, Xi Li*. G-Protein-Coupled Receptor 30 Mediates the Anticancer Effects Induced by Eicosapentaenoic Acid in Ovarian Cancer Cells. Cancer Res Treat. 2020 Jul;52(3):815-829. 5、Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y*, Zhao S*, Wang T*. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal of Biological Sciences. 2023; 19(14): 4672-4688. 6、Danyang Chong#, Zhong Chen#, Shan Guan, Tongyu Zhang, Na Xu, Yue Zhao*, Chaojun Li*. Geranylgeranyl pyrophosphate regulates endothelial cell proliferation and anti- apoptosis during vascular development in the mouse embryo through mediating protein geranylgeranylation. J Genet Genomics. 48(2021):300-311. 7、Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei, Qi-Qun Tang, Xi Li. p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1Differentiation. Mol Cell Biol. 2014,34(3):315-324. 8、Jia Liu#, Shan Jiang#, Yue Zhao#, Qian Sun, Jing-Zi Zhang, Di Shen, Jing Wu, Ning Shen, Xiao Fu, Xi-Tai Sun, De-Cai Yu, Jun Chen, Jian He, Ting-Ting Shi, Yi-Tao Ding, Lei Fang, Bin Xue*, Chao-Jun Li*. Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. J Pathol. 2018;246(3):277-288. (Commentary by Fullerton MD. Does prenylation predict progression in NAFLD? J Pathol. 2019) 9、Jing-Hui Jiang#, Yue Zhao#, Liu-Ling Xiao, Cui-Song Zhu, Shu-Fen Li, Xi Li. Activating transcription factor 5 regulates lipid metabolism in adipocytes. Science Bulletin. 2016;61(23):1802–1809. 10、Qiao-Li Tang, Shan Jiang, Wen-Jun Jia, Di Shen, Yu-Dong Qiu, Yue Zhao*, Bin Xue*, Chao-Jun Li*. Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis. Eur J Pharmacol. 2017;814:169-177. 11、Dan-Dan Zhao, Jing Wu, Yin-Juan Zhao, Wei Shao, Qi Cheng, Xiao-Yan Shao, Xian-Wen Yuan, Juan Ye, Jian-Pu Gao, Mei-Ling Jin, Chao-Jun Li, Xiao-Lin Chen, Yue Zhao* and Bin Xue*. Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis. Cancer Cell Int (2020) 20:46. 12、Ruoyu Zhao , Binghao Wang, Yan Guo, Jingzi Zhang, Danqi Chen, Wei Ming He, Yong Juan Zhao , Yibing Ding , Chunyuan Jin, Chaojun Li, Yue Zhao*, Wei Ren*, Lei Fang*.Quantitative Proteomics Reveals Arsenic Attenuates Stem-Loop Binding Protein Stability via a Chaperone Complex Containing Heat Shock Proteins and ERp44. Proteomics. 2021 Aug;21(16):e2100035. 13、Jing Wu, Dandan Bu, Haiquan Wang, Di Shen, Tongyu Zhang, Weiwei Tao, Mengfei Zhao, Yue Zhao, Peng Li, Bin Xue* & Chao-Jun Li*. The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nat Commun. 2023(14):1634. 14、Zhi-Chun Zhang, Yan Liu, Liu-Ling Xiao, Shu-Fen Li, Jing-Hui Jiang, Yue Zhao, Shu-Wen Qian, Qi-Qun Tang, Xi Li. Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. J Hepatol. 2015;63(6):1466-75. 15、Jing-Zi Zhang, Ruo-Yu Zhao, Clinton Yu, Christine L. N., Bryant Kenneth Wu, Zhi-Hong Liu, Yi-Bing Ding, Yue Zhao, Bin Xue, Zhen-Qiang Pan, Chao-Jun Li*, Lan Huang*, Lei Fang*. IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. J Proteome Res. 2020;19(3):1119-1130. 16、Jing-Zi Zhang, Neng Tang, Yin-Juan Zhao, Ruo-Yu Zhao, Xiao Fu, Dan-Dan Zhao, Yue Zhao, Lan Huang, Chao-Jun Li, Yu-Dong Qiu*, Bin Xue*, Lei Fang*. Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. J Proteome Res. 2020;19(4):1788-1799. 17、Jing Wu, Wei-Wei Tao, Dan-Dan Bu, Yue Zhao, Tong-Yu Zhang, Dan-Yang Chong, Bin Xue, Zhen Xing, Chao-Jun Li. Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes. FEBS Lett. 2019;593(21):3054-3063. 18、Zhi-Chun Zhang, Yuan Liu, Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang and Xi Li. Suv39h1 Mediates AP-2α-Dependent Inhibition of C/EBPα Expression during Adipogenesis. Mol Cell Biol. 2014;34(12):2330-8. 19、Shu-Fen Li, Liang Guo, Shu-Wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-You Shou, Qi-Qun Tang, Xi Li. G9a is Transactivated by C/EBPβ to Facilitate Mitotic Clonal Expansion during 3T3-L1 Preadipocyte Differentiation. Am J Physiol Endocrinol Metab. 2013;304(9):E990-8. 20、Yong-Juan Sang#, Qiang Wang#, Feng Zheng, Yue Hua, Xin-Ying Wang, Jing-Zi Zhang, Kang Li, Hai-Quan Wang, Yue Zhao, Min-Sheng Zhu*, Hai-Xiang Sun*, Chao-Jun Li*. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. J Mol Cell Biol. 2021;13(2):116-127. 21、Dan-Dan Zhao, Jun Yuan, Qi Cheng, Ya-Ling Qi, Ke Lu, Shan-Shan Lai, Qian Sun, Yue Zhao, Lei Fang, Mei-Ling Jin, De-Ccai Yu, Yu-Dong Qiu, Chao-Jun Li, Jun Chen, Bin Xue. Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett. 2019;17(2):1523-1530. 1.國家自然科學基金專項項目，T2341015，2024/01-2026/12，主持 2.國家自然科學基金面上項目，32271182，2023/01-2026/12，主持 3.國家自然科學基金青年基金項目，31601153，2017/01-2019/12，主持 4.江蘇省科學基金優秀青年基金項目，BK20200061，2020/07-2023/06，主持 5.江蘇省科學基金青年基金項目，BK20160619，2016/07-2019/06，主持 6.中國博士後基金面上項目，2016M601778，2016/01-2017/12，主持 7.中央高校基本科研業務費-國際合作交流項目、原創與交叉研究項目、國家自然科學基金培育項目、國家重點平台研究項目等，主持 8.國家重大研究計劃“糖脂代謝的時空網絡調控”項目，91857109，2019/01-2023/12，參與 9.國家重點研發計劃重點專項，2018YFC1004700，2018/12-2021/12，參與 10.江蘇省社會發展基金面上項目，BE2017708，2017/07-2020/06，參與 1.江蘇省“優秀青年”基金獲得者，2020 |