醫學博士，解放軍東部戰區總醫院神經外科副主任，全軍神經外科研究所神經介入中心主任，主任醫師，南京大學教授，南京大學、南京醫科大學、南方醫科大學、南京中醫藥大學博士生導師，博士後導師，第二軍醫大學、東南大學、江蘇大學及南京工業大學碩士研究生導師。1999年開始從事神經介入的臨床與基礎工作，在腦血管疾病介入診斷、治療方面積累了豐富的經驗，對複雜的顱内動脈瘤、腦動靜脈畸形及硬膜動靜脈瘘等的栓塞治療有深入的研究。每年完成各類腦血管疾病的介入治療近600餘例，以第一或通訊作者共發表文章90餘篇（其中SCI 30篇）。江蘇省“科教強衛”重點人才，江蘇省六大人才高峰培養對象，作為第一負責人主持國家自然基金等外源性課題8項，2014年獲江蘇省新技術引進獎一等獎。2016年獲全軍醫療成果三等獎。

先後任中國醫師協會神經介入專業委員會委員，中華醫學會神經外科分會神經介入學組委員，中國醫師協會神經外科分會神經介入專業委員會委員，中國腦防委外科專業委員會常務委員，中國卒中學會神經介入分會委員，江蘇省卒中學會常務理事兼神經介入專業委員會副主任委員，江蘇省醫學會神經外分會常委兼神經介入學組組長，江蘇省醫學會介入醫學分會委員兼神經介入組組長，江蘇省醫學會卒中分會委員，南京醫學會神經外科分會副主任委員等。

1. Xiangsheng Zhang, Qi Wu, Yue Lu, Jieru Wan, Haibin Dai, Xiaoming Zhou, Shengyin Lv, Xuemei Chen, Xin Zhang, Chunhua Hang, Jian Wang. Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways.Free Radical Biology and Medicine，124（2018）:504-516. https://doi.org/10.1016/j.freeradbiomed.2018.06.035

2. 呂盛銀，張鑫。動脈瘤性蛛網膜下腔出血認知功能障礙的評估及研究進展。醫學研究生學報，2018，31（8）：859-863。

3. Jiang Shao, Qi Wu, Sheng-yin Lv, Xiao-ming Zhou, Xiang-sheng Zhang, Li-li Wen, Jin Xue, Xin Zhang. Allicin attenuates early brain injuruy after experimental subarachnoid hemorrhage in rats. Journal of Clinical Neuroscience.https://doi.org/10.1016/j.jocn.2019.01.024.

4. 袁斌，張鑫，吳琪，文立利，陳姝娟，鄧金龍。動脈瘤性蛛網膜下腔出血後靜脈早顯合并過度灌注一例并文獻複習。中華神經外科雜志，2019，35（3）315-317。

5. 袁斌，張鑫，吳琪，文立利，尤宗琦，徐偉東，陳姝娟，鄧金龍。大腦中動脈粥樣硬化性狹窄支架置入後高灌注腦出血的研究進展。中國腦血管病雜志，2019，16（3）：158-163。

6. Xiangsheng Zhang, Yue Lu, Qi Wu, Haibin Dai, Wei Li, Shengyin Lv, Xiaoming Zhou, Xin Zhang, Chunhua Hang, and Jian Wan. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. The FASEB Journal, 27 Dec 2018, https://doi.org/10.1096/fj.201800642RR.

7. 尤宗琦，吳琪，周曉明，張翔聖，袁斌，徐偉東，唐祥龍，張鑫。蝦青素納米載藥顆粒靶向神經元細胞的可行性研究。中華實驗外科雜志，2019，8（36）：1387-1390。

8. Xiaoming Zhou, Qi Wu, Yue Lu, Xiangsheng Zhang, Shengyin Lv, Jiang Shao, Yuan Zhou, Jigang Chen, Lijun Hou, Chengguang Huang, and Xin Zhang. A crosstalk between soluble PDGF-BB and PDGFRb promotes astrocytic activation and synaptic recovery in the hippocampus after subarachnoid hemorrhage. The FASEB Journal,2019,33, 0892-6638/19/0033-0001.

9. Zong-qi You, Qi Wu, Xiao-ming Zhou, Xiang-sheng Zhang, Bin Yuan, Li-li Wen, Wei-dong Xu, Sheng Cui, Xiang-long Tang and Xin Zhang. Receptor-mddiater delivery of astaxanthin-loaded nanoparticles to Neurons: An enhanced potential for subarachnoid hemorrhage treatment. Front Neurosci, 2019 Sep 18;13:989.

10. Xin-Yu Lu and  Xin Zhang. Onyx™ embolization for an angiographically progressive traumatic pseudoaneurysm of the middle meningeal artery: A case report and literature review. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019(17):  4144-4148.

11. Bin Yuan, Xiao-ming Zhou, Zong-qi You, Wei-dong Xu, Jie-mei Fan, Shu-juan Chen, Yan-ling Han, Qi Wu and Xin Zhang. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death and Disease ,(2020) 11:76

12. Wei-dong Xu, Han Wang, Qi Wu, Li-Li Wen, Zong-qi You, Bin Yuan, Shu-juanChen, Han-Dong Wang, Xin Zhang. Morphology parameters for rupture in middle cerebral artery mirror aneurysms. J NeuroIntervent Surg 2020;0:1–5. doi:10.1136/neurintsurg-2019-015620

13. Bin Yuan, Xiao-ming Zhou, Jie-mei Fan, Shu-juan Chen, Zong-qi You, Wei-dong Xu, Li-li Wen, Jin-long Deng, Qi Wu, Xin Zhang. Safety and efficacy of different therapeutic strategies in the endovascular treatment of anterior cerebral artery aneurysms with different features: A single centre experience. Clinical Neurology and Neurosurgery 193 (2020) 105786.

14. Zhizhong Yan, Zhonghua Shi, Yuhai Wang, Chunlei Zhang, Jiaming Cao, Chunlong Ding, Mirui Qu, Yunbao Xia, Jin Cai, Xin Zhang, and Handong Wang. Efficacy and Safety of Low-Dose Tirofiban for Acute Intracranial Atherosclerotic Stenosis Related Occlusion with Residual Stenosis after Endovascular Treatment. Journal of Stroke and Cerebrovascular Diseases, 2020 Apr;29(4):104619.

15. 唐曉宇，文立利，吳琪，張安，周龍江，張鑫。小尺寸自膨式支架在顱内小血管動脈瘤治療中的應用。《中國腦血管病雜志》２０２０，１７（9）538-542。

16. Zhao Shi, Chongchang Miao, U. Joseph Schoepf, Rock H. Savage, Danielle M. Dargis, Chengwei Pan, Xue Chai, Xiu Li Li, Shuang Xia, Xin Zhang, Yan Gu, Yonggang Zhang, Bin Hu, Wenda Xu, Changsheng Zhou, Song Luo, Hao Wang, Li Mao, Kongming Liang， Lili Wen, Longjiang Zhou, Yizhou Yu, Guang Ming Lu，Long Jiang Zhang。A clinically applicable deep-learning model for detecting intracranial aneurysm in computed tomography angiography images。NATURE COMMUNICATIONS | (2020) 11:6090 (共同第一作者)

17. 姚磊,吳琪,文立利,周曉明,何偉臻,張閏秋,鄧金龍,陳姝娟,張鑫。Enterprise支架重建技術治療椎動脈夾層動脈瘤的效果分析。《中國腦血管病雜志》,2021,18( 1 ):18-24.

18. Yao lei,Qi Wu, Bin Yuan, Lili,Wen,Renxin Yi, Xiaoming Zhou,Weizhen He, Runqiu Zhang, Shujuan Chen, Xin Zhang. Correlation Between Vascular geometry changes and long-term outcomes after Enterprise stent deployment for intracranial aneurysms located on small ateries. World Neurosurg, 2021 Sep;153:e96-e104.

19. Wen LL, Zhou XM, Lv SY, Shao J, Wang HD, Zhang X .Outcomes of high-grade aneurysmal subarachnoid hemorrhage patients treated with coiling and ventricular intracranial pressure monitoring. World Journal of Clinical Cases 2021 Volume 9 Issue 19。

20. Wei Cai, Qi Wu, Zhi-Zhong Yan, Wei-Zhen He, Xiao-Ming Zhou, Long-Jiang Zhou, Jian-Yong Zhang, Xin Zhang. Neuroprotective effect of ultrasound triggered astaxanthin release nanoparticles on early brain injury after subarachnoid hemorrhage. Front Chem,2021 Oct 21;9:775274.

21. Lili Wen, Longjiang Zhou, Qi Wu. Early Microcirculatory Hemodynamic Changes Are Correlated With Functional Outcomes at Discharge in Patients With Aneurysmal SAH. Front Neurol,2022 Jan 20;12:793411.

22. Xiaoyu Tang, Longjiang Zhou, Lili Wen. Morphological and Hemodynamic Characteristics Associated With the Rupture of Multiple Intracranial Aneurysms.Front Neurol,2022 Jan 20;12:811281.

23. Weizhen He, Xiaoming Zhou, et al. Acetyl CoA synthase 2 potentiates ATG5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage. J Mol Histol,2022 Apr;53(2):511-521.

24. Lili Wen, Longjiang Zhou, Qi Wu, Xiaoming Zhou and Xin Zhang. Feasibility of FDCT Early Brain Parenchymal Blood Volume Maps in Predicting Short-Term Prognosis in Patients With Aneurysmal Subarachnoid Hemorrhage. Front. Neurol. 13:888369.

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