張冰
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學術地位:張冰教授,伟德官网手机版附屬鼓樓醫院黨委副書記,醫學影像中心主任;南京大學醫學影像與人工智能研究所所長,南京大學腦科學研究院功能影像中心主任。南京大學醫學博士,主任醫師,教授,碩士/博士生/博士後導師。美國Mayo Clinic博士後。擔任中國醫師協會放射醫師分會委員,中國阿爾茨海默病協會理事兼影像專委會副主委,中國醫院協會醫學影像中心分會常務委員兼秘書長,江蘇省醫學會放射學分會常委兼質智學組組長,江蘇省醫學會腦卒中分會副主任委員兼腦血管影像學組組長,江蘇省醫師協會放射醫師分會副會長,江蘇省研究型醫院協會影像人工智能專業委員會主任委員,南京醫學會放射分會副主任委員。中華醫學會放射學分會“傑出青年醫學影像學家”、江蘇省“333高層次人才培養工程”第二層次培養對象、江蘇省醫學重點人才(“十二五”和“十三五”)、江蘇省醫師協會“傑出青年醫師”獎獲得者、江蘇省“六大人才高峰”高層次人才、南京市有突出貢獻中青年專家。 研究方向:神經影像學;分子影像學;人工智能。包括:阿爾茲海默病及相關認知障礙疾病;腦功能影像及神經機制研究;高分辨成像在腦血管病中研究;胎兒腦發育的功能影像與神經機制研究;腦腫瘤功能影像與預測轉歸研究;醫學影像大數據與人工智能算法及應用研究。 業務能力:作為臨床首選的活體無創診斷方法,新一代影像人工智能已經成為突破 “早期診治窗口期前移”“卡脖子”問題的重大變革性技術。申請人以此為目标開展系列研究,創立嗅覺和空間導航腦功能磁共振成像新技術,聯合人工智能和能譜CT,在國際上率先發現認知障礙和血管病變的超早期影像标志物,提高了臨床治療決策水平和效率。基于這些成果,獲科技部“腦科學與類腦”項目和基金委國家級課題5項、全國醫療人工智能創新獎、江蘇醫學科技一等獎、江蘇333高層次人才和醫學重點人才。申請人引領我國神經影像智能診斷技術研究領域,成果被國内外同行廣泛關注,被納入專家共識4項,國際磁共振學會、歐洲認知神經分會在Radiology同期述評等正面評價申請人成果為 “全球領先、重大突破技術”、“引領影像人工智能人機耦合的研究思想”。目前,相關技術已與聯影等企業合作轉化,推廣到協和、天壇等30多家知名醫院,覆蓋1億多人口健康,成為首批解決國家重大需求的新産業、新場景項目。 成果水平:論文發表在Radiology (IF: 29.146,獨立通訊)、Diabetes Care(IF:17.152,2篇,共同第一)、Advanced Science(IF:17.521,共同通訊)、EBioMedicine(獨立通訊)、Human brain mapping(獨立通訊)、European Radiology(獨立通訊)、Neuroimage(獨立通訊)等放射學、神經影像學、糖尿病國際權威期刊。論文總引用3137次,2017年至今引用2686次,H指數29,i10指數75,單篇最高引用419次;入選中國影像醫學高價值論文。 發表國内核心期刊論文57篇(中華期刊16篇)。制定行業标準2項,發表國内專家共識1篇,國際專家共識1篇。主編著作2部,獲省市級科技獎勵18項。2022年獲得科技部“腦科學與類腦研究”特重大項目子課題負,主持國家自然科學基金5項(重點國際合作項目1項,重大課題培育1項),省自然科學基金,省醫學重點人才項目,江蘇省社會發展項目-臨床前沿技術,江蘇省科技廳社會發展重大科技示範,南京市工信局項目各一項,省333人才工程第二梯隊,六大人才高峰,南京市突出貢獻中青年及省市級課題20項,獲得國家知識産權局專利8項,軟件著作權 12 項。其中國家自然科學基金重點國際合作課題是國家“一帶一路”示範工程。 l國家級學術任職 中國醫師協會放射醫師分會第五屆委員會委員 阿爾茨海默病防治協會影像專委會副主任委員 阿爾茨海默病防治協會第二屆理事會理事 中國醫院協會醫學影像中心分會第三屆委員會常務委員兼秘書長 l省級學術任職 江蘇省醫師協會放射醫師分會第四屆委員會副會長 江蘇省醫學會第二屆腦卒中分會委員會副主任委員兼腦血管影像學組組長 江蘇省醫學會第十一屆放射學分會委員會常務委員兼質智學組組長 江蘇省研究型醫院協會影像人工智能專業委員會主任委員 江蘇省卒中學會第二屆醫學影像專業委員會副主任委員 江蘇省醫院協會第八屆醫院藥事管理專業委員會副主任委員 江蘇省醫院協會第三屆醫院院辦管理專業委員會副主任委員 l市級學術任職 南京市醫學會放射學分會第十四屆委員會主任委員 南京醫院協會第五屆理事會醫院藥事管理專業委員會主任委員 主流SCI_一作/通訊 1) Wang J#, Wu S#, Sun Y, Lu J, Zhang J, Fang Y, Qing Z, Liang X, Zhang W, Chen Q, Zhang X, Zhang B*(獨立通訊作者): Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study. Brain Imaging and Behavior 2022. (IF: 3.224,JCR Q2區,中科院大類/小類:2/3區,被引用次數:0) 2) Lv P#, Ma G#, Chen W#, Liu R, Xin X, Lu J, Su S, Li M, Yang S, Ma Y, Rong P, Dong N, Chen Q, Zhang X, Han X*, Zhang B*(共同通訊作者): Brain morphological alterations and their correlation to tumor differentiation and duration in patients with lung cancer after platinum chemotherapy. Frontiers in Oncology 2022, 12.(IF: 5.738,JCR Q2區,中科院大類/小類:3/3區,被引用次數:0) 3) Xin X#, Ni X#, Shi K, Shao J, Zhang Y, Peng X, Yang W, Tian C, Zhou W*, Zhang B*(共同通訊作者): Iodine-Rich Nanoadjuvants for CT Imaging–Guided Photodynamic Immunotherapy of Breast Cancer. Frontiers in Bioengineering and Biotechnology 2022, 10.(IF: 6.064, JCR Q1區,被引用次數:0) 4) Mu D#, Wang X#, Wang H, Sun X, Dai Q, Lv P, Liu R, Qi Y, Xie J, Xu B*, Zhang B*(共同通訊作者): Chemiexcited Photodynamic Therapy Integrated in Polymeric Nanoparticles Capable of MRI Against Atherosclerosis. International Journal of Nanomedicine 2022, 17:2353-2366.(IF:7.033,JCR Q2區,中科院大類/小類:2/2區,被引用次數:0) 5) Cheng H#, Zhang Z#, Zhang B#(共同第一作者), Zhang W, Wang J, Ni W, Miao Y, Liu J, Bi Y*: Enhancement of Impaired Olfactory Neural Activation and Cognitive Capacity by Liraglutide, but not Dapagliflozin or Acarbose, in Patients With Type 2 Diabetes: A 16-Week Randomized Parallel Comparative Study. Diabetes Care 2022, 45(5):1201-1210.(IF:17.152,JCR Q1區,中科院大類/小類:1/1區,被引用次數:0) 6) Ding J, Duan Y, Wang M, Yuan Y, Zhuo Z, Gan L, Song Q, Gao B, Yang L, Liu H, Hou Y, Zheng F, Chen R, Wang J, Lin L, Zhang B*(共同通訊作者), Zhang G*, Liu Y: Acceleration of Brain Susceptibility-Weighted Imaging with Compressed Sensitivity Encoding: A Prospective Multicenter Study. American Journal of Neuroradiology 2022, 43(3):402-409.(IF:4.966,JCR Q2區,中科院大類/小類:2/2區,被引用次數:0) 7) Maoxue Wang#, Yiming Ma#, Fei Chen, Fei Zhou, Jilei Zhang, Bing Zhang*(獨立通訊作者): Acceleration of pCASL-based cerebral 4D MR angiography using Compressed SENSE: a comparison with SENSE. Frontiers in Neurology 2022. 21(13):796271(IF:4.086,JCR Q2區,中科院大類/小類:3/3區,被引用次數:0) 8) Maoxue Wang#, Yi Wang#, Wen Zhang, Xiance Zhao, Yongbo Yang*, Bing Zhang*(共同通訊作者): Preoperative collateral perfusion using arterial spin labeling: a predictor of surgical collaterals in moyamoya angiopathy. Frontiers in Neuroscience 2022. 14(16):839485. (IF:5.125,中科院大類/小類:3/3區) 9) Zhang W#, Lu J#, Qing Z#, Zhang X, Zhao H, Bi Y#, Zhang B*(獨立通訊作者), Alzheimer's Disease Neuroimaging I: Effects of Subcortical Atrophy and Alzheimer's Pathology on Cognition in Elderly Type 2 Diabetes: The Alzheimer's Disease Neuroimaging Initiative Study. Frontiers in Aging Neuroscience 2022, 14:781938.(IF:5.702, JCR Q1區,中科院大類/小類:2/2區,被引用次數:0) 10) Dan Mu#, Junjie Bai#, Wenping Chen, Hongming Yu, Jing Liang, Kejie Yin, Hui Li, Zhao Qing, Kelei He, Hao-Yu Yang, Jinyao Zhang, Youbing Yin, Hunter W. McLellan, U. Joseph Schoepf, Bing Zhang*(獨立通訊作者): Calcium Scoring in Coronary CT Angiography using Deep Learning. Radiology 2022,302(2): 309-316. (IF: 29.146, JCR Q1區,中科院大類/小類:1/1區,被引用次數:1) 11) Danyan Li#, Xiaowei Han#, Jie Gao, Qing Zhang, Haibo Yang, Shu Liao, Hongqian Guo*,Bing Zhang*(共同通訊作者). Deep Learning in Prostate Cancer Diagnosis Using Multiparametric Magnetic Resonance Imaging With Whole-Mount Histopathology Referenced Delineations. Front Med (Lausanne) 2021, 8: 810995. (IF:5.091,2022年IF:5.058,中科院大類/小類:3/2區,被引用次數:0,2022年IF:5.058) 12) Lu J#, Chen Q#, Li D#, Zhang W, Xing S, Wang J, Zhang X, Liu J, Qing Z, Dai Y, Zhang B*(獨立通訊作者): Reconfiguration of Dynamic Functional Connectivity States in Patients With Lifelong Premature Ejaculation. Frontiers in Neuroscience 2021, 15:721236. (IF:4.677,2022年IF:5.152,中科院大類/小類:3/3區,被引用次數:0) 13) Sun L, Guo J, Chen H, Zhang D, Shang L*, Zhang B*, Zhao Y*(共同通訊作者): Tailoring Materials with Specific Wettability in Biomedical Engineering. Advance Science (Weinh) 2021, 8(19):e2100126. (IF:16.806,2022年IF:17.521,JCR Q1區,中科院大類/小類:1/1區,被引用次數:1) 14) Zhou WJ, Zhang YD, Kong WT, Zhang CX, Zhang B*(獨立通訊作者): Preoperative prediction of axillary lymph node metastasis in patients with breast cancer based on radiomics of gray-scale ultrasonography. Gland Surgery 2021, 10(6):1989-2001. (IF: 2.953,2022年IF:2.16, JCR Q2區,中科院大類/小類:2/2區,被引用次數:1) 15) Li W#, Zhao H, Qing Z, Nedelska Z, Wu S, Lu J, Wu W, Yin Z, Hort J, Xu Y, Zhang B*(獨立通訊作者): Disrupted Network Topology Contributed to Spatial Navigation Impairment in Patients With Mild Cognitive Impairment. Frontiers in Aging Neuroscience2021, 13:630677.(IF:5.75,2022年IF:5.702, JCR Q1區,中科院大類/小類:2/2區,被引用次數:0) 16) Mu D#, Wang W, Li J, Lv P, Liu R, Tan Y, Zhong C, Qi Y, Sun X, Liu Y, Shen S, Li Y, Xu B*, Zhang B*(共同通訊作者): Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques. ACS Applied Materials & Interfaces 2021, 13(29):33915-33925. (IF:9.229,2022年IF:10.383,中科院大類/小類:1/2區,被引用次數:4) 17) Chen C#, Kong W#, Liang J#, Lu J, Chen D, Sun Y, Zhang X, Qing Z, Feng X, Sun L*, Zhang B*(共同通訊作者): Impaired olfactory neural circuit in patients with SLE at early stages. Lupus 2021, 30(7):1078-1085. (IF:2.911,2022年IF:2.858, JCR Q3 區,中科院大類/小類:3/4區,被引用次數:0) 18) Liu X#, Du L#, Zhang B#(共同第一作者), Zhao Z, Gao W, Liu B, Liu J, Chen Y, Wang Y, Yu H, Ma G*: Alterations and Associations Between Magnetic Susceptibility of the Basal Ganglia and Diffusion Properties in Alzheimer's Disease. Frontiers in Neuroscience2021, 15:616163. (IF:4.677,2022年IF:5.152,中科院大類/小類:3/3區,被引用次數:1) 19) Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B*(共同通訊作者), Chen G*, Liu HK*, Qian Y*: In Vivo Brain Imaging of Amyloid-beta Aggregates in Alzheimer's Disease with a Near-Infrared Fluorescent Probe. ACS Sensors 2021, 6(3):863-870. (IF:7.711,2022年IF:9.618, JCR Q1區,中科院大類/小類:1/1區,被引用次數:4) 20) Zhang W#, Gao C#, Qing Z, Zhang Z, Bi Y, Zeng W*, Zhang B*(共同通訊作者): Hippocampal subfields atrophy contribute more to cognitive impairment in middle-aged patients with type 2 diabetes rather than microvascular lesions. Acta Diabetologica 2021, 58(8):1023-1033. (IF:4.28,2022年IF:4.087, JCR Q2 區,中科院大類/小類:3/3區,被引用次數:0) 21) Xiaoyan Xin#, Ran Mo#, Mingran Shao, Wen Yang, Daixin Li, Yanqiu Zhang, Han Wang, Baiyun Liu, Song Tian, Weidao Chen, Jiangfen Wu, Bin Zhu, Kefeng Zhou, Chao Du*, and Zhang B*(共同通訊作者):A Human–Computer Collaboration for COVID-19 Differentiation: Combining a Radiomics Model with Deep Learning and Human Auditing. Annals of Palliative Medicine. 2021, 10(7):7329-7339. (IF:2.595,2022年IF:1.925, JCR Q3 區,中科院大類/小類:2/2區,被引用次數:0) 22) Qing Z#, Chen F, Lu J, Lv P, Li W, Liang X, Wang M, Wang Z, Zhang X, Zhang B*(獨立通訊作者): Causal structural covariance network revealing atrophy progression in Alzheimer's disease continuum. Human brain mapping 2021, 42(12):3950-3962. (IF:5.038,2022年IF:5.399, JCR Q1區,中科院大類/小類:2/2區,被引用次數:0) 23) Wang T#, Yang F, Wang Z, Zhang B*(共同通訊作者), Wang W*, Liu F*: Modularization of grid cells constrained by the pyramidal patch lattice. iScience 2021, 24(4),102301. (IF:5.458,2022年IF:6.107,中科院大類/小類:2/2區,被引用次數:0) 24) Li X#, Wang Z, Chen Q, Wang X, Qing Z, Zhang W, Lu J, Wang J, Zhang X, Liu J, Wang Z*, Li B*, Zhang B*(共同通訊作者): Atrophy in the Left Amygdala Predicted Drug Responses in Idiopathic Generalized Epilepsy Patients With Tonic–Clonic Seizures. Frontiers in Neuroscience 2021, 15: 236. (IF:4.677,2022年IF:5.152,中科院大類/小類:3/3區,被引用次數:1) 25) Chen Q#, Lu J#, Zhang X#, Sun Y, Chen W, Li X, Zhang W, Qing Z, Zhang B*(獨立通訊作者): Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline. Frontiers in Aging Neuroscience 2021, 13:646017.(IF:5.75,2022年IF:5.702, JCR Q1區,中科院大類/小類:2/2區,被引用次數:4) 26) Chen Q#, Qing Z#, Jin J#, Sun Y, Chen W, Lu J, Lv P, Liu J, Li X, Wang J, Zhang W, Wu S, Yan X, Nedelska Z, Hort J, Zhang X*, Zhang B*(共同通訊作者): Ego- and allo-network disconnection underlying spatial disorientation in subjective cognitive decline. Cortex 2021, 137:35-48.(IF:4.027,2022年IF: 4.644, JCR Q1區,中科院大類/小類:2/1區,被引用次數:0) 27) Chen Q#, Wu S#, Li X#, Sun Y, Chen W, Lu J, Zhang W, Liu J, Qing Z, NedelskaZ, Hort J, Zhang X, Zhang B*(獨立通訊作者): Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline. Frontiers in Aging Neuroscience 2021, 13:50. (IF:5.75,2022年IF:5.702, JCR Q1區,中科院大類/小類:2/2區,被引用次數:3) 28) Wang M#, Yang Y, Wang Y, Li M, Zhang J, Zhang B*(獨立通訊作者): Vessel-selective 4D MRA based on ASL might potentially show better performance than 3D TOF MRA for treatment evaluation in patients with intra-extracranial bypass surgery: a prospective study. European Radiology 2021, 31: 5263–5271. (IF: 5.315,2022年IF:7.034, JCR Q1區,中科院大類/小類:2/2區,被引用次數:0) 29) Zhang W#, Qing Z, Hu Y, Shao M, Lu J, Wang J, Li M, Zhang X, Nedelska Z, Hort J, Wang Z, Qiao T*, Zhang B*(共同通訊作者): Thalamic Atrophy Plays a Crucial Role in the Effect of Asymptomatic Carotid Stenosis on Cognitive Impairment. Clinical Interventions in Aging 2020, 15:2083-2094. (IF:3.023,中科院大類/小類3/3區,被引用次數:0) 30) Zhang S#, Xin X#, Wang Y, Guo Y, Hao Q, Yang X, Wang J, Zhang J*, Zhang B*(共同通訊作者), Wang W*: Automated Radiological Report Generation For Chest X-Rays With Weakly-Supervised End-to-End Deep Learning; 2020, Basic & Clinical Pharmacology & Toxicology. (IF:2.651,JCR Q3區,中科院大類/小類3/3區,被引用次數:0) 31) Yuan L#, Li D#, Mu D, Zhang X, Kong W, Cheng L, Shu X, Zhang B*(獨立通訊作者), Wang Z*: Combined T2 SPAIR, Dynamic Enhancement and DW Imaging Reliably Detect T Staging and Grading of Bladder Cancer With 3.0T MRI. Frontiers in Oncology 2020, 10:582532.(IF: 4.848, JCR Q2區,中科院大類/小類3/3區,被引用次數:2) 32) Yang Q#, Xu H, Tang X, Hu C, Wang P, Wáng YXJ, Wang Y, Ma G*, Zhang B*(共同通訊作者): Medical Imaging Engineering and Technology Branch of the Chinese Society of Biomedical Engineering expert consensus on the application of Emergency Mobile Cabin CT. Quantitative Imaging in Medicine and Surgery 2020, 10(11):2191-2207. (IF:3.226, JCR Q2區,中科院大類/小類:2/2區,被引用次數:1) 33) Wu S#, Upadhyay N, Lu J, Jiang X, Li S, Qing Z, Wang J, Liang X, Zhang X, Zhang B*(獨立通訊作者): Interaction of Catechol-O-methyltransferase Val158Met polymorphism and sex influences association of parietal intrinsic functional connectivity and immediate verbal memory. Brain and Behavior 2020:e01784. (IF:2.091, JCR Q3區,中科院大類/小類:4/4區,被引用次數:2) 34) Wang Z#, Zhang X#, Liu R, Wang Y, Qing Z, Lu J, Obeso I, Zhang B*(共同通訊作者), Li Y*: Altered sulcogyral patterns of orbitofrontal cortex in patients with mild cognitive impairment. Psychiatry Research-Neuroimaging 2020, 302:111108. (IF: 2.063, JCR Q3區,中科院大類/小類:4/4區,被引用次數:4) 35) Wang Y#, Lu X-F#, Chen L-L, Zhang Y-W, Zhang B*(獨立通訊作者): Multiple neurofibromas plus fibrosarcoma with familial NF1 pathogenicity: A case report.World journal of clinical cases 2020, 8(7):1306-1310. (IF: 1.013, JCR Q3區,中科院大類/小類:4/4區,被引用次數:0) 36) Wang Y#, Lu X#, Zhang Y#, Zhang X, Wang K, Liu J, Li X, Hu R, Meng X, Dou S, Hao H, Zhao X, Hu W, Li C, Gao Y, Wang Z, Lu G, Yan F*, Zhang B*(共同通訊作者): Precise pulmonary scanning and reducing medical radiation exposure by developing a clinically applicable intelligent CT system: Toward improving patient care. EBioMedicine 2020, 54:102724. (IF: 5.736, JCR Q1區,中科院大類/小類:2/1區,被引用次數:15) 37) Wang Y, Lu X, Zhang B*(獨立通訊作者): Ileal diffuse ganglioneurosis with jejunal malrotation. Asian Journal of Surgery 2020, 43(5):642-643. (IF:1.838, JCR Q3區,中科院大類/小類:3/3區,被引用次數:0) 38) Wang Y, Chen T, Lu X, Zhang B*(獨立通訊作者): Malignant gastrointestinal neuroectodermal tumor in the small intestine with liver metastasis: First case report worldwide. Asian Journal of Surgery 2020, 43(7):769-772. (IF:1.838, JCR Q3區,中科院大類/小類:3/3區,被引用次數:0) 39) Wang J#, Wu S#, Sun Y, Fang Y, Wu R, Lu J, Qing Z, Liang X, Wang Z, Zhang W, Chen Q, Cao P, Zhang B*(獨立通訊作者): Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults. Behavioural Brain Research 2020, 384:112550. 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