張愛華
電話:18951769017郵箱:zhaihua@njmu.edu.cn 地址:研究方向:

兒童腎髒病

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  • 學術兼職
  • 代表性論文
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  • 獲獎情況

張愛華,二級教授、主任醫師、博士生導師,國家傑出青年科學基金獲得者,享受國務院政府特殊津貼專家,科技部中青年科技創新領軍人才,江蘇省特聘教授,江蘇省“333工程第一層次培養對象,南京醫科大學附屬兒童醫院副院長/腎髒科學科帶頭人,江蘇省兒童重大疾病研究重點實驗室主任,南京醫科大學兒科研究所所長。

一直緻力于兒童慢性腎髒病和急性腎損傷的發病機制與早期幹預的研究,主持國家傑出青年科學基金1項、國家自然科學基金重點項目2項、國家重點研發計劃重大專項課題2項等國家和部省級課題,共計20餘項。在Science Translational MedicinePNAS、腎髒病領域頂級期刊J Am Soc NephrolKidney Int以及JBC等發表SCI收錄論文160餘篇,累計影響因子600餘分。獲批國家發明專利8項,相關研究成果先後獲得教育部自然科學一等獎、中國婦幼健康科學技術獎自然科學獎二等獎、江蘇省衛生計生委醫學新技術引進獎一等獎、江蘇省科學技術二等獎和三等獎以及中華腎髒病青年研究者獎等。


中華醫學會兒科分會腎髒學組組長、江蘇省醫學會罕見病分會首屆主任委員/兒科分會副主任委員,同時兼任《Kidney Disease》雜志副主編;《American Journal of Physiology Renal》、《World Journal of Pediatrics》等期刊雜志編委

1.Nuclear receptor PXR targets AKR1B7 to protect mitochondrial   metabolism and renal function in AKI. Sci   Transl Med.2020 May 13;12(543):eaay7591. doi: 10.1126/ scitranslmed.aay7591.(通訊作者, IF=17.16

2.Response to   comment on ”Nuclear receptor PXR targets AKR1B7 to protect mitochondrial   metabolism and renal function in AKI”. Sci Transl Med. 2021 May 12;13(593):eabf9849(通訊作者,IF=17.992

3.Dimethyl   fumarate prevents ferroptosis to attenuate acute kidney injury by acting on   NRF2. Clin Transl Med. 2021 Apr;11(4):e382.    doi: 10.1002/ctm2.382. (通訊作者,IF=11.492

4.Reduced Lon protease 1 expression in podocytes contributes to the   pathogenesis of podocytopathy.Kidney Int.   2021 Apr;99(4):854-869.(通訊作者,IF=10.612

5.MicroRNA-214   promotes chronic kidney disease by disrupting mitochondrial oxidative   phosphorylation. Kidney Int. 2019   Jun;95(6):1389-1404. (通訊作者,IF=8.945

6.Functional   Characterization of PHEX Gene Variants in Children With X-Linked   Hypophosphatemic Rickets Shows No Evidence of Genotype-Phenotype Correlation.   J Bone Miner Res. 2020 Apr 24. doi:   10.1002/jbmr.4035.(通訊作者,IF=6.741

7.Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the   Pathogenesis of Cardiovascular Disease.Front Immunol.   2022 May 26;13:893204.(通訊作者,IF= 7.5607

8.Isoliquiritin Ameliorates Cisplatin-Induced Renal Proximal Tubular   Cell Injury by Antagonizing Apoptosis, Oxidative Stress and Inflammation.Front Med (Lausanne). 2022 Mar 30;9:873739. (通訊作者,IF= 5.0929

9.Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase   Inhibitors in Treating Nonanemic Diseases.Front Pharmacol. 2022 Feb 24;13:837249.(通訊作者,IF=5.8106

10.Maintaining   homeostasis of mitochondria and endoplasmic reticulum with NSC228155   alleviates cisplatin-induced acute kidney injury.Free Radic Biol Med. 2022   Mar;181:270-287. doi: 10.1016/j.freeradbiomed.2022.02.003.通訊作者,IF=7.3762

11.mPGES-2   blockade antagonizes β-cell senescence to ameliorate diabetes by acting on   NR4A1.Nat Metab. 2022 Feb;4(2):269-283.(通訊作者,IF=13.5102

12.Computational Systems Pharmacology, Molecular Docking and   Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the   Treatment of Glomerulonephritis.J Inflamm Res. 2021 Dec 16;14:6939-6958.通訊作者,IF=6.922

13.Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6   Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction.Front Cell Dev   Biol. 2021 Oct 21;9:754134.(通訊作者,IF=6.684

14.Roxadustat prevents Ang II hypertension by targeting angiotensin   receptors and eNOS.JCI Insight. 2021 Sep 22;6(18):e133690.(通訊作者,IF=8.315

15.SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by   Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome   Activation.Kidney Dis (Basel). 2021 Jul;7(4):293-305.通訊作者,IF=3.222

16.Blocking AURKA   with MK-5108 attenuates renal fibrosis in chronic kidney disease. BiochimBiophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166227.通訊作者,IF=5.1867

17. Anti-anemia drug FG4592 retards the AKI to CKD transition by   improving vascular regeneration and anti-oxidative capability. Clin Sci   (Lond). 2021 Jul13:CS20210100. doi: 10.1042/CS20210100. Epub ahead of print. (通訊作者,IF=6.124

18.Clinical and Functional Characterization of Novel INSR Variants in   Two Families With Severe Insulin Resistance Syndrome. Front Endocrinol   (Lausanne). 2021 Apr 29;12:606964. doi:10.3389/fendo.2021.606964. (通訊作者,IF=5.555

19.Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced   Acute Liver Injury. Front Pharmacol. 2021 Apr 23;12:626166. doi:   10.3389/fphar.2021.626166.(通訊作者,IF=5.8

20.The novel STING antagonist H151 ameliorates cisplatin-induced   acute kidney injury and mitochondrial dysfunction. Am J Physiol Renal   Physiol. 2021 Apr1; 320(4):F608-F616. doi: 10.1152/ajprenal.00554.2020. Epub   2021 Feb 22. (通訊作者,IF=3.377

21. Multi-centre study of the clinical features and gene variant   spectrum of Gitelman syndrome in Chinese children. Clin Genet. 2021 Apr;   99(4):558-564. doi:10.1111/cge.13913. Epub 2021 Feb (通訊作者,IF=4.438

22. Gasdermin E deficiency attenuates acute kidney injury by   inhibiting pyroptosis and inflammation. Cell Death Dis. 2021 Feb 1;   12(2):139. doi: 10.1038/s41419-021-03431-2. (通訊作者,IF=8.469

23.Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by   Inhibiting the TGF-β1-Smad2/3 Signaling Pathway. Front Med (Lausanne). 2021   Jan21; 7:626140. doi: 10.3389/fmed.2020.626140.(通訊作者,IF=5.091

24.Celastrolinhibits intestinal lipid absorption by reprofiling the   gut microbiota to attenuate high-fat diet-induced obesity. iScience. 2021 Jan   20;24(2):102077.doi: 10.1016/j.isci.2021.102077. (通訊作者, IF=5.458

25.Targeting microsomal prostaglandin E synthase 1 to develop drugs   treating the inflammatory diseases. Am J Transl Res. 2021 Jan15;   13(1):391-419. (通訊作者,IF=4.06

26.The emerging role of MEIS1 in cell proliferation and   differentiation. Am J Physiol Cell Physiol. 2020 Dec 9. doi:   10.1152/ajpcell.00422.2020. Online ahead of print.(通訊作者,IF=3.452

27.Mitochondrial Dysfunction and the AKI to CKD Transition. Am J   Physiol Renal Physiol. 2020 Oct 19. doi: 10.1152/ajprenal.00285.2020.   Online ahead of print.(通訊作者,IF=3.323

28.miR-214   Protects Against Uric Acid-Induced Endothelial Cell Apoptosis. Front Med   (Lausanne). 2020 Aug 5;7:411. doi: 10.3389/fmed.2020.00411. eCollection   2020. (通訊作者,IF= 5.093

28.LIM-Nebulette   Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin   Filaments. J Am Soc Nephrol. 2020 Oct;31(10):2372-2391.(通訊作者,IF=10.121

29.New   Criterion to Evaluate Acute-on-Chronic Kidney Injury Based on the Creatinine   Reference Change. Am J Nephrol.   2020 Apr 29:1-10. doi: 10.1159/000506664. Online ahead of print.(通訊作者,IF=3.745

30.Inhibition of ROCK2 alleviates renal fibrosis and the   metabolic disorders in the proximal tubular epithelial cells. Clin Sci (Lond). 2020 Jun   26;134(12):1357-1376.(通訊作者,IF=5.127

31.   Chinese Society of Pediatric Nephrology and Chinese Medical Doctor   Association of Pediatric Nephrology. Consensus recommendations for the care   of children receiving chronic dialysis in association with the COVID-19   epidemic. Pediatr Nephrol. 2020 Apr   24. doi: 10.1007/s00467-020-04555-x. (通訊作者,IF=3.714

32.IPDN-China   investigators. IPDN-China promotes the development of pediatric dialysis in   China. Pediatr Nephrol. 2020 Nov;35(11):2163-2171. (通訊作者,IF=3.714

33.Splicing   Characterization of CLCNKB Variants in Four Patients With Type III   Bartter Syndrome.Front Genet. 2020   Feb 21;11:81. doi: 10.3389/fgene.2020.00081. eCollection 2020.(通訊作者,IF=3.517

34.Trehalose   attenuates renal ischemia-reperfusion injury by enhancing autophagy and   inhibiting oxidative stress and inflammation.Am J Physiol Renal Physiol. 2020 Feb 18. doi:   10.1152/ajprenal.00568.2019. [Epub ahead of print](通訊作則,IF=3.323

35.Ursodeoxycholic   acid protects against cisplatin-induced acute kidney injury and mitochondrial   dysfunction through acting on ALDH1L2.Free   Radic Biol Med. 2020 Jan 28. pii: S0891-5849(19)31732-0. doi:   10.1016/j.freeradbiomed.2020.01.182. (通訊作者, IF=5.657

36.Inhibition of   PDE4/PDE4B improves renal function and ameliorates inflammation in   cisplatin-induced acute kidney injury.Am   J Physiol Renal Physiol. 2020 Mar 1;318(3):F576-F588(通訊作者,IF=3.323

37.MicroRNA-214   targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell   apoptosis.Apoptosis. 2020   Feb;25(1-2):92-104. doi: 10.1007/s10495-019-01582-4.(通訊作者,IF=4.6767

38.Activation of   GSDMD contributes to acute kidney injury induced by cisplatin.Am J Physiol Renal Physiol. 2020 Jan   1;318(1):F96-F106. doi: 10.1152/ajprenal.00351.2019. (通訊作者,IF=3.323

39.Multicenter   study of the clinical features and mutation gene spectrum of Chinese children   with Dent disease.  Clin Genet. 2020 Mar;97(3):407-417.   doi: 10.1111/cge.13663.(通訊作者,IF=4.104

40.BMP1   inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD.Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1430-F1438. doi:   10.1152/ajprenal.00230.2019.(通訊作者,IF=3.323

41.Rotenone   protects against β-cell apoptosis and attenuates type 1 diabetes mellitus.Apoptosis. 2019 Dec;24(11-12):879-891. doi:   10.1007/s10495-019-01566-4.(通訊作者,IF=4.6767

42.Genetic   spectrum of renal disease for 1001 Chinese children based on a multicenter   registration system. Clin Genet.   2019 Jul 22. doi: 10.1111/cge.13606. [Epub ahead of print] (通訊作者,IF=4.104

43.Celastrol   attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3   inflammasome activation. Cell Death   Discov. 2019 Jul 5;5:114. doi: 10.1038/s41420-019-0196-0.(通訊作者,IF=4.1137

44. Mitochondrial   activity contributes to impaired renal metabolic homeostasis and renal   pathology in STZ-induced diabetic mice. Am J Physiol Renal Physiol. 2019 Jul   3. doi: 10.1152/ajprenal.00076.2019. [Epub ahead of print](通訊作者,IF=3.191

45.Inhibition of   mitochondrial activity ameliorates atherosclerosis in ApoE-/- mice via   suppressing vascular smooth cell activation and macrophage foam cell   formation. J Cell Biochem. 2019 May   26. doi: 10.1002/jcb.29042. [Epub ahead of print] (通訊作者,IF=3.448

46.Inhibition of   the mitochondrial complex-1 protects against carbon tetrachloride-induced   acute liver injury. Biomed   Pharmacother. 2019 Jul;115:108948. (通訊作者,IF=3.743

47.Adenosine   kinase inhibition protects against cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol. 2019 Jul   1;317(1):F107-F115. (通訊作者,IF=3.191

48.Understanding   kidney injury molecule 1: a novel immune factor in kidney pathophysiology. Am J Transl Res. 2019 Mar   15;11(3):1219-1229. (通訊作者,IF=3.375

49.Acute Kidney   Injury among Hospitalized Children in China. Clin J Am Soc Nephrol.2018 Dec 7;13(12):1791-1800.(通訊作者,IF=6.243

50.Inhibition of   mitochondrial complex I activity attenuates neointimal hyperplasia by   inhibiting smooth muscle cell proliferation and migration. Chem Biol Interact. 2019 May   1;304:73-82. (通訊作者,IF=3.407

51.Inhibition of   mitochondrial complex I by rotenone protects against acetaminophen-induced   liver injury. Am J Transl Res. 2019   Jan 15;11(1):188-198. (通訊作者, IF=3.266

52.Estrogen-related   receptor-α mediates puromycin aminonucleoside-induced mesangial cell   apoptosis and inflammatory injury. Am J   Physiol Renal Physiol. 2019;316(5):F906-F913. (通訊作者,IF=3.126

53.NLRP3   deletion inhibits inflammation-driven mouse lung tumorigenesis induced by   benzo(a)pyrene and lipopolysaccharide. Respir   Res. 2019 Jan 29;20(1):20. doi: 10.1186/s12931-019-0983-4.(通訊作者,IF=3.294


1.      Meis1:調控線粒體穩态阻斷腎髒纖維化的新機制(82090022),國家自然科學基金重大項目課題,2021.01-2025.12430萬元,主持

2.      WWP2介導的泛素化修飾:免疫性腎小球疾病炎性損傷的新機制(81830020),2019.1-2023.12,國家自然科學基金重點項目,294萬元,主持

3.      高膽固醇及緻病基因對心血管發育的影響及調控機制(2019YFA0802702),國家重點研發計劃, 2019.12-2024.11104.85萬元,主持

4.      兒童ANCA相關性腎炎規範化診療策略研究(BE2021607),江蘇省社會發展——臨床前沿技術,2021.7-2024.6200萬元,主持

5.      兒童慢性腎髒病的基礎與臨床研究,江蘇省高水平大學建設專項經費,2019-2024500萬元,主持

6.      線粒體穩态調控:腎髒纖維化幹預的新靶标(81530023),國家自然科學基金重點項目,2016.01-2020.12328.8萬元,主持

7.      免疫性腎病的幹預靶點研究(2016YFC0906103),國家重點研發計劃重大專項(The National Key Research and Development   Program of China),2016.07-2020.12320萬元,主持

8.      兒童慢性腎髒病的基礎與臨床研究(JCRCB2016008),江蘇省醫學傑出人才基金,2016-2020150萬元,主持

9.      兒童過敏性紫癜和紫癜性腎炎的規範化診治(ZDX16009),南京市十三五醫學科技創新重大項目,2017.01-2019.1280萬元,主持

10.  江蘇省特聘教授,江蘇省政府,2016.01-2018.12200萬元,主持

11.  慢性腎髒病(81325004),國家傑出青年科學基金,2014.01-2017.12320萬元,主持

12.  兒童紫癜性腎炎規範性診治策略研究(BL2014007),江蘇省臨床醫學科技重大專項,2014.07.01-2017.06.30200萬元,主持

13.  miR-30e通過抑制SIRT1/PGC-1α信号通路誘導線粒體功能障礙和足細胞損傷(81270797),國家自然科學基金面上項目,2013-201670萬元,主持


1. Minigene技術在兒童罕見遺傳病基因診斷中的應用,江蘇省衛生計生委2021年度醫學新技術引進獎一等獎,2021年,第一完成人

2. 二代測序技術在兒童罕見遺傳性疾病診斷中的應用,江蘇省醫學新技術引進獎一等獎,2018年(排名第一)

3. 氧化應激在兒童慢性腎髒病發病機制及早期幹預中作用的研究,全國婦幼健康科學技術獎自然科學獎二等獎,2017年(排名第一)

4. 兒童慢性腎髒病進展的關鍵機制與早期診治研究,江蘇醫學科技獎二等獎,2016年(排名第二)

5. 氧化應激在慢性腎髒病的發生與進展中的作用及幹預研究,江蘇省科學技術獎二等獎,2014年(排名第一)

6. 慢性腎髒病進展關鍵機制及其診斷标志物研究,教育部自然科學獎一等獎,2014年(排名第二)

7. 氧化應激在小兒慢性腎髒病的發病機制及早期幹預中的作用,宋慶齡兒科醫學獎,2013年(排名第二)

8. 腎髒纖維化的細胞分子機制及其幹預研究,江蘇省科技進步三等獎,2010年。(排名第一)

9. JNK信号通路活化在小兒慢性腎髒病發病機制和早期診斷中的作用,江蘇省醫學科技獎二等獎,2010年。(排名第一)

10. 氧化應激介導的MAPK信号通路活化在小兒慢性腎髒病中作用的研究,江蘇省科技進步三等獎,2009年。(排名第二

 


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