醫學博士、主任醫師、教授、博導，現為南京醫科大學附屬腦科醫院副院長、精神大科主任、心境障礙科主任、江蘇省抑郁症專病中心主任、南京神經精神病學研究所副所長。入選江蘇省科教強衛工程領軍人才、優秀醫學重點人才，獲江蘇省“333工程”第二層次人才、江蘇省六大高峰人才、江蘇省醫學拔尖人才、江蘇省有突出貢獻中青年專家等稱号。帶領的臨床團隊榮獲江蘇省“科教強衛工程”省市共建醫學創新團隊、全國人文愛心科室、五一巾帼标兵崗等稱号。發表論文200餘篇，獲國家發明授權4項、軟件著作權2項。相關研究成果獲華夏醫學科技獎三等獎（2021）、江蘇省科技進步獎二等獎（2020、2014）、江蘇省醫學科技進步獎二等獎（2015）、南京市科學技術進步獎二等獎（2015）、三等獎（2013）、江蘇省醫學新技術引進獎一等獎（2013、2016、2021）和南京市醫學新技術引進獎特等獎（2020）、一等獎（2016）等。

中華醫學會精神醫學分會委員兼抑郁障礙研究協作組副組長

中國醫師協會精神科委員兼精準醫療專委會副主委

江蘇省醫師協會精神科醫師分會會長

江蘇省醫學會精神醫學分會第九屆主委

江蘇省精神科專業醫療質控中心主任

[1]Yan R, Geng JT, Huang YH, Zou HW, Wang XM, Xia Y, Zhao S, Chen ZL, Zhou H, Chen Y et al: Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study. BMC Psychiatry 2022, 22(1):146.

[2]Wang X, Qin J, Zhu R, Zhang S, Tian S, Sun Y, Wang Q, Zhao P, Tang H, Wang L et al: Predicting Treatment Selections for Individuals with Major Depressive Disorder According to Functional Connectivity Subgroups. Brain Connect 2022. https://doi.org/10.1089/brain.2021.0153

[3]Shao J, Zhang Y, Xue L, Wang X, Wang H, Zhu R, Yao Z, Lu Q: Shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2022. https://doi.org/10.1038/s41386-022-01290-9

[4]Zhou H, Zou H, Dai Z, Zhao S, Hua L, Xia Y, Han Y, Yan R, Tang H, Huang Y et al: Interoception Dysfunction Contributes to the Negative Emotional Bias in Major Depressive Disorder. Frontiers in psychiatry 2022, 13:874859.

[5]Wang Q, Tian S, Zhao P, Cao Q, Lu Q, Yao Z: Association Between Antidepressant Efficacy and Interactions of Three Core Depression-Related Brain Networks in Major Depressive Disorder. Frontiers in psychiatry 2022, 13:862507.

[6]Chen Z, Zhao S, Tian S, Yan R, Wang H, Wang X, Zhu R, Xia Y, Yao Z, Lu Q: Diurnal mood variation symptoms in major depressive disorder associated with evening chronotype: Evidence from a neuroimaging study. Journal of affective disorders 2022, 298(Pt A):151-159.

[7]Dai Z, Pei C, Zhang S, Tian S, Chen Z, Zhou H, Lu Q, Yao Z: Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response. CNS Neurosci Ther 2022, 28(3):401-410.

[8]Yan R, Huang Y, Shi J, Zou H, Wang X, Xia Y, Zhao S, Zhou H, Chen Y, Li X et al: Alterations of regional spontaneous neuronal activity and corresponding brain circuits related to non-suicidal self-injury in young adults with major depressive disorder. Journal of affective disorders 2022, 305:8-18.

[9]Dai Z, Shao J, Zhou H, Chen Z, Zhang S, Wang H, Jiang H, Yao Z, Lu Q: Disrupted fronto-parietal network and default-mode network gamma interactions distinguishing suicidal ideation and suicide attempt in depression. Progress in neuro-psychopharmacology & biological psychiatry 2022, 113:110475.

[10]Zhang S, Litvak V, Tian S, Dai Z, Tang H, Wang X, Yao Z, Lu Q: Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder. Eur Arch Psychiatry Clin Neurosci 2022:1-11.

[11]Sun Y, Wang X, Tian S, Chen Z, Wang H, Xue L, Yan R, Yao Z, Lu Q: An Investigation into the Association Between Dopamine Receptor D1 Multilocus Genetic Variation, Multiparametric Magnetic Resonance Imaging, and Antidepressant Treatment. J Magn Reson Imaging 2022, 56(1):282-290.

[12]Wang H, Zhu R, Tian S, Zhang S, Dai Z, Shao J, Xue L, Yao Z, Lu Q: Dynamic connectivity alterations in anterior cingulate cortex associated with suicide attempts in bipolar disorders with a current major depressive episode. Journal of psychiatric research 2022, 149:307-314.

[13]Dai Z, Shen X, Tian S, Yan R, Wang H, Wang X, Yao Z, Lu Q. Gradually evaluating of suicidal risk in depression by semi-supervised cluster analysis on resting-state fMRI. Brain Imaging Behav. 2021;15(4):2149-2158.

[14]Zhao S, Chen Z, Wang X, Yao Z, Lu Q. Increased prevalence of subclinical hypothyroidism in female hospitalized patients with depression. Endocrine. 2021;72(2):479-485.

[15]Wang X, Qin J, Zhu R, Zhang S, Tian S, Sun Y, Wang Q, Zhao P, Tang H, Wang L, Si T, Yao Z, Lu Q. Predicting treatment selections for individuals with major depressive disorder according to functional connectivity subgroups. Brain Connect. 2021 Dec 16. doi: 10.1089/brain.2021.0153.

[16] Xue L, Pei C, Wang X, Wang H, Tian S, Yao Z, Lu Q. Predicting Neuroimaging Biomarkers for Antidepressant Selection in Early Treatment of Depression. J Magn Reson Imaging. 2021 Aug;54(2):551-559.

[17]Zhang Y, Shao J, Wang X, Chen Z, Liu H, Pei C, Zhang S, Yao Z, Lu Q. Functional impairment-based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects. Hum Brain Mapp. 2021 Aug 15;42(12):4035-4047.

[18]Dai Z, Zhang S, Wang X, Wang H, Zhou H, Tian S, Chen Z, Lu Q, Yao Z. Sub-second transient activated patterns to sad expressions in major depressive disorders discovered via hidden Markov model. J Neurosci Res. 2021 Dec;99(12):3250-3260. doi: 10.1002/jnr.24942. 

[19]Zhao S, Wang X, Chen Z, Zhou H, Han Y, Tang H, Yan R, Yao Z, Lu Q. Sex differences in the association between symptom profiles and cognitive functioning in patients with depressive disorder. J Affect Disord. 2021;287:1-7.

[20] Chen Z, Tao S, Zhu R, Tian S, Sun Y, Wang H, Yan R, Shao J, Zhang Y, Zhang J, Yao Z, Lu Q. Aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: Bridging RORA gene polymorphism with diurnal mood variation in major depressive disorder. J Psychiatr Res. 2021;132:123-130.

[21]Tang H, Xiong T, Shi J, Chen Y, Liu X, Zhang S, Wang H, Lu Q, Yao Z. Global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes. BMC Psychiatry. 2021,26;21(1):117.

[22]Xue L, Pei C, Wang X, Wang H, Tian S, Yao Z, Lu Q. Predicting Neuroimaging Biomarkers for Antidepressant Selection in Early Treatment of Depression. J Magn Reson Imaging. 2021;54(2): 551-559.

[23]Sun Y, Tao S, Tian S, Shao J, Mo Z, Wang X, Wang H, Zhao P, Chen Z, Yao Z, Lu Q. Serotonin 2A receptor polymorphism rs3803189 mediated by dynamics of default mode network: a potential biomarker for antidepressant early response. J Affect Disord. 2021,15;283:130-138.

[24]Tian S, Zhu R, Chattun MR, Wang H, Chen Z, Zhang S, Shao J, Wang X, Yao Z, Lu Q. Temporal dynamics alterations of spontaneous neuronal activity in anterior cingulate cortex predict suicidal risk in bipolar II patients. Brain Imaging Behav.  2021, 15(5):2481-2491. 

[25] Qiao J, Tao S, Wang X, Shi J, Chen Y, Tian S, Yao Z, Lu Q. Brain functional abnormalities in the amygdala subregions is associated with anxious depression. J Affect Disord. 2020;276:653-659.

[26] Han YL, Dai ZP, Ridwan MC, Lin PH, Zhou HL, Wang HF, Yao ZJ, Lu Q. Connectivity of the Frontal Cortical Oscillatory Dynamics Underlying Inhibitory Control During a Go/No-Go Task as a Predictive Biomarker in Major Depression. Front Psychiatry. 2020;11:707. 

[27]Jiang H, Zhu R, Tian S, Wang H, Chen Z, Wang X, Shao J, Qin J, Shi J, Liu H, Chen Y, Yao Z, Lu Q. Structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode. Neuropsychopharmacology. 2020; 45(10):1735-1742.

[28]Wang H, Zhu R, Dai Z, Tian S, Shao J, Wang X, Sun Y, Chen Z, Li X, Yao Z, Lu Q. Aberrant functional connectivity and graph properties in bipolar II disorder with suicide attempts.  J Affect Disord. 2020; 275:202-209.

[29]Yang Y,  Chattun MR,  Yan R,  Zhao K,  Chen Y,  Zhu R,  Shi J,  Wang X,  Lu Q,  Yao Z. Atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters. Brain Imaging and Behavior. 2020,14(6):2542-2552. IF 3.418.

[30] Zhao P,  Yan R,  Wang X,  Geng J,  Chattun MR,  Wang Q,  Yao Z,  Lu Q. Reduced resting state neural activity in the right orbital part of middle frontal gyrus in anxious depression. Frontiers in Psychiatry 2020; 10: 994. IF 3.161.

[31] Zhou H,  Hua L,  Jiang H,  Dai Z,  Han Y,  Lin P,  Wang H,  Lu Q,  Yao Z. Autonomic nervous system is related to inhibitory and control function through functional Inter-Region connectivities of OFC in major depression. Neuropsychiatr Dis Treat 2020; 16: 235-247.

[32] Tian S,  Zhang S,  Mo Z,  Chattun MR,  Wang Q,  Wang L,  Zhu R,  Shao J,  Wang X,  Yao Z,  Si T,  Lu Q. Antidepressants normalize brain flexibility associated with multi-dimensional symptoms in major depressive patients. Progress in Neuropsychopharmacology& Biological Psychiatry, 2020; 100: 109866.

[33]Tian S,  Sun Y,  Shao J,  Zhang S,  Mo Z,  Liu X,  Wang Q,  Wang L,  Zhao P,  Chattun MR,  Yao Z,  Si T,  Lu Q. Predicting escitalopram monotherapy response in depression: The role of anterior cingulate cortex. Hum Brain Mapp. 2020;41:1249–1260. doi: 10.1002/hbm.24872.

[34] Zhou H, Dai Z, Hua L, Jiang H, Tian S,Han Y, Lin P, Wang H, Lu Q and Yao Z. (2020) Decreased Task-Related HRV is Associated With Inhibitory Dysfunction Through Functional InterRegion Connectivity of PFC in Major Depressive Disorder. 2020, Frontiers Psychiatry 10:989. IF 3.161.

[35] Chattun MR, Zhang S, Chen Y, Wang Q, Amdanee N, Tian S, Lu Q, Yao Z. Caudothalamic dysfunction in drug-free suicidally depressed patients: an MEG study.  European Archives of Psychiatry and Clinical Neuroscience. 2020, 270(2):217-227.

[36] Rongxin Zhu, Shui Tian, Huan Wang, Haiteng Jiang, Xinyi Wang, JunNeng Shao, Qiang Wang, Rui Yan, Shiwan Tao, Haiyan Liu, Zhijian Yao, Qing Lu. Discriminating Suicide Attempters and Predicting Suicide Risk Using Altered Frontolimbic Resting-State Functional Connectivity in Patients With Bipolar II Disorder. Frontiers in Psychiatry,2020,11:597770.

[37] Wang Q, Shi J, Zhao P, Cao Q, Yao Z. Neuroleptic malignant syndrome with abnormally elevated cardiac troponin I: a case report. J Int Med Res. 2020 Nov;48(11):300060520968344.

[38] Pei C, Sun Y, Zhu J, Wang X, Zhang Y, Zhang S, Yao Z, Lu Q. Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder. J Magn Reson Imaging. 2020;52(1):161-171.

[39]Jiang H, Hua L, Dai Z, Tian S, Yao Z, Lu Q, Popov T. Spectral fingerprints of facial affect processing bias in major depression disorder. Soc Cogn Affect Neurosci. 2019. 257:74-82.

[40] Jiang H,  Dai Z,  Lu Q,  Yao Z. Magnetoencephalography resting-state spectral fingerprints distinguish bipolar depression and unipolar depression. Bipolar Disorders. 2020, 22(6):612-620.

[41]Bi K , Luo GP, Tian S, Zhang SQ, Liu XX , Wang Q, Lu Q, Yao ZJ.An enriched granger causal model allowing variable static anatomical constraints [J].NeuroImage: Clinical, 2019, 21:101592.

[42] Shao J, Dai Z, Zhu R, Wang X, Tao S, Bi K, Tian S, Wang H, Sun Y, Yao Z, Lu Q. Early identification of bipolar from unipolar depression before manic episode: Evidence from dynamic rfMRI. Bipolar Disord. 2019, 21(8):774-784. Epub ahead of print. IF 4.936

[43] Jiang HT, Tian S, Bi K, Lu Q, Yao ZJ. Hyperactive frontolimbic and frontocentral resting-state gamma connectivity in major depressive disorder. J Affect Disord. 2019,2;257:74-82. IF 4.084.

[44] Yan R, Tao S, Liu H, Chen Y, Shi J, Yang Y, Zhu R, Yao Z and Lu Q. Abnormal Alterations of Regional Spontaneous Neuronal Activity in Inferior Frontal Orbital Gyrus and Corresponding Brain Circuit Alterations: A Resting-State fMRI Study in Somatic Depression. Frontiers in Psychiatry,2019, 10:267.

[45]Wang X, Qin J, Zhu J, Bi K, Zhang SQ, Yan R, Zhao P, Yao ZJ, Qing Lu. Rehabilitative compensatory mechanism of hierarchical subnetworks in major depressive disorder: A longitudinal study across multi-sites[J]. European psychiatry, 2019.58: 54-62.

[46]Wang Q, Tian S, Tang H, Liu XX, Yan R, Hua LL, Shi JB, Chen Y, Zhu RX, Lu Q, Yao ZJ. Identification of major depressive disorder and prediction of treatment response using functional connectivity between the prefrontal cortices and subgenual anterior cingulate: A real-world study[J]. Journal of Affective Disorder, 2019, 252:365-372.

[47] Tian S, Mohammad RidwanChattun, Zhang SQ, Bi K, Tang H, Yan R, Wang Q, Yao ZJ, Lu Q. Dynamic Community Structure in Major Depressive Disorder: A RestingState MEG Study. Progress in Neuropsychopharmacology& Biological Psychiatry. 2019,92,39-47.

[48] Geng JT, Yan R, Shi JB, Chen Y, Mo ZQ, Shao JN, Wang XY, Yao ZJ, Lu Q. Altered regional homogeneity in patients with somatic depression: A resting-state fMRI study.Journal of Affective Disorders, 2019, 246:498-505. IF 4.084.

[49] Zhang Q, Zhang P, Yan R, Xu X, Mao C, Liu X, Li F, Ma J, Ye L, Yao Z, Wu J. A Single-Blinded Trial Using Resting-State Functional Magnetic Resonance Imaging of Brain Activity in Patients with Type 2 Diabetes and Painful Neuropathy. Diabetes Therapy, 2019, 10(1):135-147.

[50]Shi JB, Geng JT, Yan R, Liu XX, Chen Y, Zhu RX, Wang XY, Shao JN, Bi Q, Yao ZJ, Lu Q. Differentiation of transformed bipolar disorder from unipolar depression by resting-state functional connectivity within reward circuit. Frontiers in psychology, 9:2586.

[51] Liu HY, Zhao ZK, Shi JB, Chen CY, Yao ZJ, Lu Q. Topological Properties of Brain Structural Networks Represent Early Predictive Characteristics for the Occurrence of Bipolar Disorder in Patients With Major Depressive Disorder: A 7-Year Prospective Longitudinal Study. Frontiers in Psychiatry, 2018,9:704.

[52]Bi K , Mohammad RC, Liu XX , Wang Q, Tian S, Zhang SQ, Lu Q, Yao ZJ. Abnormal early dynamic individual patterns of functional networks in low gamma band for depression recognition[J]. Journal of Affective Disorders, 2018.238：366-374.

[53] Tao S, Chattun MR, Yan R, Geng J, Zhu R, Shao J, Yao Z, Lu Q. TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom. Frontiers in Neuroscience. 2018, 12:827.

[54] Chen JH, Chen Y, Gao QQ, Chen GT, Dai YT, Yao ZJ, Lu Q. Impaired prefrontal-amygdala pathway, self-reported emotion and erection in psychogenic erectile dysfunction patients with normal nocturnal erection[J]. Frontiers in Human Neuroscience, 2018, 12: 157.

（1）國家自然科學基金委員會, 面上項目, 81871066, 抑郁症晝夜節律變化的視交叉上核gamma波腦網絡的調控機制, 2019-01-01 至 2022-12-31, 56萬元, 在研, 主持

（2）國家科技部, 國家重點研發計劃重大慢性非傳染性疾病防控研究重點專項, 2018YFC1314601, 抑郁症複發的預警體系建立和綜合幹預策略研究項目--抑郁症複發的臨床表型、風險因子研究, 2018-09 至 2021-06, 86萬元, 結題, 主持

（3）江蘇省衛健委, 江蘇省衛健委科研重點項目, K2019011, 基于多維度特征的重性抑郁發作患者自殺風險防控策略研究, 2020-01 至 2022-12, 20萬元, 在研, 主持

（4）江蘇省科技廳, 江蘇省社會發展--臨床前沿技術, BE2018609, 基于多源數據的抑郁症防控關鍵技術與策略研究, 2018-07 至 2021-06, 400萬元, 結題, 主持

（5）江蘇省衛生和計劃生育委員會, 江蘇省“科教強衛工程”省市共建創新團隊, CXTDC2016004, 基于影像遺傳學信息的抑郁症關鍵技術研究, 2016-01 至 2020-12, 300萬元, 結題, 主持

華夏醫學科技獎三等獎（2021）、江蘇省科技進步獎二等獎（2020、2014）、江蘇省醫學科技進步獎二等獎（2015）、南京市科學技術進步獎二等獎（2015）、三等獎（2013）、江蘇省醫學新技術引進獎一等獎（2013、2016、2021）和南京市醫學新技術引進獎特等獎（2020）、一等獎（2016）等。