袁阿虎博士
副教授/博士生導師
電話:郵箱:yuannju@nju.edu.cn 地址:南京市漢口路22号研究方向:

微納米制劑及其在腫瘤免疫治療中的應用

  • 個人簡介
  • 學術兼職
  • 代表性論文
  • 承擔科研項目
  • 獲獎情況

工作簡曆:

2024.07~至今        伟德官网手机版 博士生導師

2019.12~至今        伟德官网手机版 副教授

2015.09~2019.11  伟德官网手机版 副研究員


科研情況簡介:

副教授,博士生導師,曾在美國北卡羅萊納大學教堂山分校(University of North Carolina at Chapel Hill)藥學院訪學。近年來,主要關注微納米藥物自組裝機制、規模化制備及其在抗腫瘤免疫治療中的應用。圍繞該領域,在Nature Communications, Advanced MaterialsAdvanced ScienceACS Nano, Advanced Functional Materials(封面論文)等期刊發表SCI論文40餘篇。獲得2017年教育部技術發明一等獎2018年江蘇省專利金獎、2019年江蘇省科協青年科技人才托舉工程、2020年教育部自然科學一等獎、2022年江蘇省333高層次人才(第3層次)等獎項或支持。


中國藥學會 會員;中國化學會 會員;Nanomaterials 期刊編委;

Nature Communications, Advanced MaterialsACS NanoJ Controlled Release等期刊審稿人;


[1] Zhusheng Huang, Rong Gu, Shiqian Huang, Qian Chen, Jing Yan, Xiaoya Cui, Haojie Jiang, Dan Yao, Chuang Shen, Jiayue Su, Tao Liu, Jinhui Wu, Zhimin Luo*, Yiqiao Hu*, Ahu Yuan*Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination,Nature Communications, 2024. 

[2] Yuxiang Wang, Weiran Wang, Rong Gu, Jing Chen, Qian Chen, Tingsheng Lin*, Jinhui Wu, Yiqiao Hu*Ahu Yuan*In Situ Vaccination with Mitochondria-Targeting Immunogenic Death Inducer Elicits CD8+ T Cell-Dependent Antitumor Immunity to Boost Tumor ImmunotherapyAdvanced Science, 2023. 

[3] Qian Chen, Jing Chen, Qingqing Zhang, Peizheng Yang, Rong Gu, Hao Ren, Yue Dai, Shiqian Huang, Jinhui Wu, Xudong Wu*, Yiqiao Hu*, Ahu Yuan*, Combining High-Z Sensitized Radiotherapy with CD73 Blockade to Boost Tumor Immunotherapy, ACS Nano, 2023.

[4] Yuxiang Wang, Jing Chen, Rumeng Duan, Rong Gu, Weiran Wang, Jinhui Wu, Huibo Lian*, Yiqiao Hu*, Ahu Yuan*High-Z-Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor VaccinationAdvanced Materials, 2022.

[5] Zhusheng Huang, Dan Yao, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Gadolinium–Zoledronic acid Coordination Polymer Nanorods for Improved Tumor Radioimmunotherapy by Synergetically Inducing Immungenic Cell Death and Reprogramming Immunosuppressive Microenvironment, ACS nano, 2021.

[6] Zhusheng Huang, Yuxiang Wang, Dan Yao, Jinhui Wu, Yiqiao Hu*, Ahu Yuan*, Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress, Nature Communications, 2021.

[7] Yuxiang Wang, Yawen Ding, Dan Yao, Hong Dong, Changwei Ji*, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Copper-Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T-Cell Infiltration, Small, 2021.

[8] Shaoju Gan, Xiaoning Tong , Yue Zhang, Jinhui Wu, Yiqiao Hu*, and Ahu Yuan*Covalent Organic Framework-Supported Molecularly Dispersed Near-Infrared Dyes Boost Immunogenic Phototherapy against TumorsAdvanced Functional Materials, 2019 (Cover Story). 

[9] W. Wang, Y. Cheng, P. Yu, H. Wang, Y. Zhang, H. Xu, Q. Ye, A. Yuan*, Y. Hu*, J. Wu*, Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy, Nature Communications, 2019.

[10] Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu*, Yiqiao Hu*Ahu Yuan*, Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal EffectsACS nano, 2018.

https://scholar.google.com/citations?hl=en&user=7ccGPxsAAAAJ


[1] 2024-2027年,長三角科技創新共同體聯合攻關項目(參與,研究骨幹);

[2] 2024-2027,國家自然科學基金面上項目(項目負責人);

[3] 2022-2025,江蘇省自然科學基金面上項目(項目負責人);

[4] 2022-2027年,國家重點研發計劃“前沿生物技術”重點專項(參與,研究骨幹);

[5] 2018-2020年,中央高校基本科研業務經費(項目負責人);

[6] 2017-2022年,國家重點研發計劃“納米科技”重點專項(參與,研究骨幹);

[7] 2016-2019,國家自然科學青年基金項目(項目負責人);

[1] 2017年,教育部技術發明一等獎(第3完成人);

[2] 2018年,南京市高層次人才(高校C類人才);

[3] 2018年,江蘇省專利金獎(主要專利發明人);

[4] 2019年,江蘇省科協青年科技人才托舉工程

[5] 2020年,教育部自然科學一等獎(第4完成人);

[6] 2022年,江蘇省第六期333人才(第三層次);


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