簡介

女

伟德官网手机版，副教授，碩士生導師

江蘇省“五一勞動獎章”和“五一創新能手”稱号獲得者

江蘇高校“青藍工程”優秀青年骨幹教師

南京大學首批“青年名師名課計劃”入選者

教育工作經曆

2006.09-2012.06 伟德官网手机版，臨床醫學，七年制

2012.09-2015.06 伟德官网手机版，臨床醫學，博士

2015.07-2018.08 伟德官网手机版，基礎醫學，助理研究員

2018.09-至今  伟德官网手机版，基礎醫學，副教授

研究方向

1.圍術期神經認知紊亂：基礎研究主要集中于晝夜節律在圍術期神經認知紊亂中的作用及機制研究；臨床研究主要集中于圍術期神經認知紊亂危險因素分析及潛在診療方案評估

2.睡眠障礙：基礎研究主要集中于圍術期睡眠障礙的發生機制；臨床研究主要集中于多模式睡眠幹預對睡眠障礙人群的作用

3.疼痛：急慢性疼痛信号的轉導與調節機制

成果簡介

科研工作：主持包括國家自然科學基金青年項日、國防科技創新培育項目、江蘇省自然科學基金青年項目在内的國家及省部級科研項目6項，作為項目骨幹參與國家自然科學基金重點項目、面上項目多項，以通訊/第一作者發表SCI論文20餘篇。

教學工作：主持江蘇省一流本科課程，參與校級各類教學改革項目多項。曾獲全國高校青年教師教學競賽一等獎，江蘇省本科高校青年教師教學競賽特等獎，江蘇省青年崗位能手，江蘇省技術能手等多個獎項。

中國神經科學學會麻醉與腦功能分會青年委員會 委員

江蘇省病理生理學會 常務理事

江蘇省高等學校醫藥教育研究會 常務理事

通訊/共同通訊作者

1. Dong, R., Lv, P., Han, Y., Jiang, L., Wang, Z., Peng, L., Ma, Z., Xia, T., Zhang, B., Gu, X. 2022. Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment. CNS Neurosci Ther, 00:1-17.

2. Han, X., Cheng, X., Xu, J., Liu, Y., Zhou, J., Jiang, L., Gu, X., Xia, T. 2022. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology, 219:1-12.

3. Peng, L., Liu S., Xu J., Xie W., Fang X., Xia, T., and Gu, X. 2022. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. Int Immunopharmacol, 109:1-8.

4. Dong, R., Han, Y., Jiang, L., Liu, S., Zhang, F., Peng, L., Wang, Z., Ma, Z., Xia, T., and Gu, X. 2022. Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice. J Neuroinflammation, 19(1):64.

5. Han, X., Liu, Y., Liu, B., Ma, Z., Xia, T., and Gu, X. 2022. TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain. J Mol Neurosci, 72(5):1075-1084.

6. Liu, T., Song, J., Zhou, Q., Chu, S., Liu, Y., Zhao, X., Ma, Z., Xia, T., and Gu, X. 2022. The role of 5-HT7R in the memory impairment of mice induced by long-term isoflurane anesthesia. Neurobiol Learn Mem, 188:107584.

7. Peng, L., Fang, X., Xu, F., Liu, S., Qian, Y., Gong, X., Zhao, X., Ma, Z., Xia, T., and Gu, X. 2021. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Front Aging Neurosci, 13:686506.

8. Liu, Y., Liu, T., Jiang, L., Liu, Q., Ma, Z., Xia, T., and Gu, X. 2021. Identification of hub genes associated with cognition in the hippocampus of Alzheimer's Disease. Bioengineered, 12(2):9598-9609.

9. Liu, B., Chu, S., Liu, T., Song, J., Ma, Z., Gu, X., and Xia, T. 2021. Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane. Chronobiol Int, 38(1):38-45.

10. Du, Y., Gong, X., Fang, X., Xing, F., Xia, T., and Gu, X. 2020. Sevoflurane plays a reduced role in cognitive impairment compared with isoflurane: limited effect on fear memory retention. Neural Regen Res, 15(1):96-102.

11. Xing, F., Fang, X., Gong, X., Zhao, X., Du, Y., Ma, Z., Gu, X., and Xia, T. 2020. Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance. Neural Regen Res, 15(6):1094-1101.

12. Liu, H., Gong, X., Zhao, X., Qian, Y., Gu, X., and Xia, T. 2020. GLYX-13 pretreatment ameliorates long-term isoflurane exposure-induced cognitive impairment in mice. Neural Regen Res, 15(1):128-135.

13. Gong, X., Xu, L., Fang, X., Zhao, X., Du, Y., Wu, H., Qian, Y., Ma, Z., Xia, T., and Gu, X. 2020. Protective effects of grape seed procyanidin on isoflurane-induced cognitive impairment in mice. Pharm Biol, 58(1):200-207.

14. Song, J., Chu, S., Fang, X., Xu, F., Zhang, P., Zhao, X., Ma, Z., Xia, T., and Gu, X. 2020. Time-restricted feeding alters isoflurane-induced memory deficits. Transl Neurosci, 11(1):341-355.

15. Song, Y., Li, X., Gong, X., Zhao, X., Ma, Z., Xia, T., and Gu, X. 2019. Green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress. J Nutr Biochem, 73:108213.

16. Song, J., Chu, S., Cui, Y., Qian, Y., Li, X., Xu, F., Shao, X., Ma, Z., Xia, T., and Gu, X. 2018. Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. Exp Neurol, 306: 45-54.

第一/共同第一作者

1. Fang, X., Xia, T., Xu, F., Wu, H., Ma, Z., Zhao, X., and Gu, X. 2020. Isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice. Brain Res, 1727:146511.

2. Xia, T., Chu, S., Cui, Y., Xu, F., Liu, Y., Song, J., Qian, Y., Shao, X., Li, X., Gu, X., and Ma, Z. 2017. The Role of NR2B-CREB-miR212/132-CRTC1-CREB Signal Network in Pain Regulation In Vitro and In Vivo. Anesth Analg, 124(6), 2045–2053.

3. Xia, T., Cui, Y., Chu, S., Song, J., Qian, Y., Ma, Z. and Gu, X. 2016. Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice. Brain Res, 1634, 12-20.

4. Cui, Y., Xia, T., Chu, S., Qian, Y., Zhang, J., Song, J., Ma, Z., and Gu, X. 2016. The role of Ca2+/calmodulin-dependent protein kinase II-cyclic AMP-responsive element binding protein signaling pathway on sensory-discriminative and affective-motivational pain responses in a rat model of chronic constriction injury of sciatic nerve. Int J Clin Exp Med, 9(6):10181-90.

5. Xia, T., Cui, Y., Qian, Y., Chu, S., Song, J., Gu, X. and Ma, Z. 2016. Regulation of the NR2B-CREB-CRTC1 Signaling Pathway Contributes to Circadian Pain in Murine Model of Chronic Constriction Injury. Anesth Analg, 122(2), 542-52.

6. Xia, T., Cui, Y., Chu, S., Ma, Z., Gu, X. 2015. Murine clock gene expression in the suprachiasmatic nuclei and peripheral blood mononuclear cells during the daily sleep-wake rhythm and after isoflurane anesthesia. Sleep Biol Rhythms, 13(4), 357-365.

7. Xia, T., Cui, Y., Shi, H., Ma, Z. and Gu, X. 2014. The effect of NR2B subunit palmitoylation at the spinal level after chronic dorsal root ganglia compression in rats. Anesth Analg, 119(5), 1208-14.

其他作者

1. Cheng, X., Gu, X., Xia, T., Ma, Z., Yang, Z., Feng, H. L., Zhao, Y., Ma, W., Ju, Z., Gorospe, M., Yi, X., Tang, H., and Wang, W. 2021. HuB and HuD repress telomerase activity by dissociating HuR from TERC. Nucleic Acids Res, 49(5):2848-2858.

2. Liu, H., Xia, T., Zhu, Z., Zhao, X., Qian, Y., Ma, Z., and Gu, X. 2019. Effect of neuromuscular blockade on transcranial electric motor evoked potentials during surgical correction for idiopathic scoliosis under total intravenous anesthesia. J Clin Monit Comput, 33(3):471-479.

3. Qian, Y., Xia, T., Cui, Y., Chu, S., Ma, Z. Gu, X. 2019. The role of CaMKII in Neuropathic Pain and Fear Memory in Chronic Constriction Injury in Rats. Int J Neurosci, 129(2):146-154.

4. Liu, H., Xia, T.,Xu, F.,Ma, Z., and Gu, X. 2018. Identification of the key genes associated with neuropathic pain. Mol Med Rep, 17(5): 6371-6378.

主持項目

1.2021年度高校“青藍工程”優秀青年骨幹教師培養對象：4萬，2021-2024

2.國家自然科學基金青年項目：RbAp48在糖皮質激素介導的老年POCD中的機制研究，20萬，2018-2020

3.國防科技創新特區培育項目：無創腦波調節技術在睡眠-覺醒節律紊亂介導的認知功能障礙中的應用，50萬，2018-2020

4.江蘇省自然科學基金青年項目：RbAp48相關組蛋白乙酰化在糖皮質激素介導的老年POCD中的作用和機制研究，20萬，2017-2020

5.中央高校基本科研業務費——原創交叉類：腦波調節系統結合VR技術在“睡眠-覺醒”節律偏移介導的老年術後認知功能障礙中的應用，30萬，2017-2019

6.中央高校基本科研業務費——人才類：乳酸穿梭失衡在EFhd2介導的老年POCD中的作用，10萬，2019-2019

7.中央高校基本科研業務費——自然基金類：RbAp48在糖皮質激素介導的老年POCD中的作用，5萬，2016-2016

參與項目

1.國家自然科學基金重點項目，第二參與人：SCOP介導的“睡眠-覺醒”節律偏移在老年POCD中的作用及機制研究，297萬，2018-2022

2.國家自然科學基金面上項目，第三參與人：脊髓水平GR-NPAS4信号通路對GABA能抑制性突觸的調節在術前焦慮加重術後疼痛中的作用，70萬，2015-2018

3.國家自然科學基金面上項目，第一參與人：“睡眠-覺醒”節律偏移在NR2B介導的老年POCD中的作用，70萬，2013-2016

1.江蘇省青年崗位能手稱号，2021

2.南京大學中國銀行教師教學成果獎，2021

3.南京大學鄭鋼基金——學業導師優秀示範獎，2021

4.南京大學檔案工作先進個人（年鑒類），2021

5.南京大學魅力導師獎，2021

6.伟德官网手机版優秀教師，2021

7.全國高校青年教師教學競賽一等獎，2020

8.全國高校（醫學類）微課教學比賽三等獎，2020

9.江蘇省五一勞動獎章，2020

10.江蘇省本科高校青年教師教學競賽特等獎，2020

11.江蘇省技術能手稱号，2020

12.江蘇省五一創新能手榮譽稱号，2020

13.《南京大學年鑒2020》優秀撰稿人，2020

14.“新華報業”南京大學優秀青年教師獎，2018

15.伟德官网手机版優秀教師獎，2018