香港大學博士  研究員/助理教授/博導 中國生物工程學會抗體委員會委員

主要研究方向：1）病毒感染的防治及緻病機制研究，2）納米抗體藥物研究，3）人工智能納米抗體藥物研發，4）基于納米抗體的工程改造，基因治療和細胞治療。緻力于針對傳染病的新型生物醫藥研發與機制探讨，并構建了具有自主産權的納米抗體藥物研發平台和多靶向抗體改造和AAV遞送抗體平台。

獲得的榮譽稱号：江蘇省雙創博士、江蘇省六大人才高峰 B類人才， 南京市高層次人才、第十五屆江蘇省青年五四獎章集體。

發表SCI論文20餘篇，以近5年來第一作者或通訊作者在Nature Communications、J Clin Invest、Cell Reports、EMBO Molecular Medicine、JCI Insight、Plos pathogen （x2）等國際高水平學術期刊發表論文10餘篇，平均IF大于10分；獲批14項國内、日本或美國的發明專利，其中3項已實現成果轉化。作為項目負責人主持國家級（2項）、省（3項）、市等各類基金11項，獲批科研經費累計超過300萬；作為任務級負責人參與國家十三五傳染病重大專項課題一項。

中國生物工程學會抗體委員會委員

1.        Zhu L, Huang B, Wang X, Ni F, Ao M, Wang R, Zheng B, Chen C, Xue J, Zhu L, Yang C, Shi L, Geng S, Hu J, Yang M, Zhang D, Yang P, Li M, Li Y, Hu Q, Ye S, Zheng P, Wei H, Wu Z(*), Zhang L(*), Wang Y(*), Liu Y(*), Wu X(*). Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration.Nature Communications. 2024;15(1):6961. （通訊作者）

2.        Ji, M., J. Hu, D. Zhang, B. Huang, S. Xu, N. Jiang, Y. Chen, Y. (*)Wang, X. Wu (*) and Z. Wu(*) (2024). Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody. EMBO molecular medicine16(3): 575-595. （共同通訊）

3.        Wu, Xilin，Lin Cheng, Ming Fu,….Yalan Liu (*) and Zhiwei Wu(*) (2021) . A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration.. Cell Reports. 2021: p. 109869-109869.（第一作者) (研發了一種通過吸入式給藥治療新冠病毒感染的新型納米抗體，該項目在2020年五四青年節獲得江蘇省委領導的參觀和表彰，并獲得2020年江蘇省青年五四獎章集，排名第一)。

4.        Nawaz, W., B. Huang, S. Xu, Y. Li, L. Zhu, H. Yiqiao, Z. Wu(*) and Xilin Wu (*) (2021). AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia. Blood cancer journal11(6): 119-119. （通訊作者）

5.        Huang, B., L. Zhu, H. Wei, H. Shi, D. Zhang, H. Yuan, L. Luan, N. Zheng, S. Xu, W. Nawaz, Y. Hong, X. Wu(*)and Z. Wu(*) (2021). Potent Neutralizing Humanized Antibody With Topical Therapeutic Potential Against HPV18-Related Cervical Cancer.Frontiers in Immunology12(2339).（共同通訊）

6.        Xu, S., N. Jiang, W. Nawaz, B. Liu, F. Zhang, Y. Liu, X. Wu (*)and Z. Wu(*)(2021). Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome. PLoS pathogens17(5): e1009587-e1009587.  （共同通訊） 

7.   Xilin Wu _(#), Yanlei Li_(#),Bilian Huang^, , Xiaohua Ma, Linjing Zhu, Nan Zheng, Shijie Xu, Waqas Nawaz, Changping Xu, Zhiwei Wu (*)A single domain antibody inhibits SFTSV infection and mitigates virus-induced pathogenesis in vivo, JCI Insight, 2020,5(13).（第一作者）(項目成果入選國家“十三五”科技創新成果展)

8.        Xiaoyan Tian; Deyan Chen; Huanru Wang; Shijie Xu; Linjing Zhu; Xilin Wu (*); Zhiwei Wu (*); The Induction and Characterization of Monoclonal Antibodies Specific to GP of Ebola Virus, Journal of Medical Virology, 2019, 2020: 1-11. （共同通訊）

9.        Nawaz, W., Xu, S., Li, Y., Huang, B., Wu, X.(*), & Wu, Z. (*). Nanotechnology and immunoengineering: How nanotechnology can boost CAR-T therapy. Acta biomaterialia 109, 21-36, doi:10.1016/j.actbio.2020.04.015 (2020).（共同通訊）

10.     Xilin Wu; Xiaohua Ma; Yanlei Li; Yue Xu; Nan Zheng; Shijie Xu; Waqas Nawaz; Zhiwei Wu, Induction of neutralizing antibodies by human papillomavirus vaccine generated in mammalian cells, Antibody Therapeutics, 2019.3, 2(2) (封面) （第一作者）

11.     Wu, Xilin; Guo, Jia; Niu, Mengyue; An, Minghui; Liu, Li; Wang, Hui; Jin, Xia; Zhang, Qi; Lam, Ka Shing; Wu, Tongjin; Wang, Hua; Wang, Qian; Du, Yanhua; Li, Jingjing; Cheng, Lin; Tang, Hang Ying; Shang, Hong; Zhang, Linqi; Zhou, Paul; Chen, Zhiwei_(*), Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. Journal of Clinical Investigation, 2018. 128(6):2239-2251  （第一作者）（首次研發的AAV遞呈的雙靶向抗體藥物首次在小鼠動物模型治愈了HIV感染，被國家衛健委科技教育司評為2018年最具影響力的十大科研成果之一）

12.     Wu, Xilin; Liu, Li; Cheung, Ka-Wai; Wang, Hui; Lu, Xiaofan; Cheung, Allen Ka Loon; Liu, Wan; Huang, Xiuyan; Li, Yanlei; Chen, Zhiwei W; Chen, Samantha M Y; Zhang, Tong; Wu, Hao; Chen, Zhiwei_(*), Brain Invasion by CD4(+) T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice., J Neuroimmune Pharmacol, 2016.9, 11(3)：572 ~ 583（第一作者）

13.     Song, P., N. Zheng, Y. Liu, C. Tian, X. Wu, X. Ma, D. Chen, X. Zou, G. Wang, H. Wang, Y. Zhang, S. Lu, C. Wu and Z. Wu (2018). Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection. Nat Commun 9(1): 3328.

14.    Cheung, Allen Ka Loon; Kwok, Hau-Yee; Huang, Yiru; Chen, Min; Mo, Yufei; Wu, Xilin; Lam, Ka-Shing; Kong, Hoi-Kuan; Lau, Terrence Chi Kong; Zhou, Jingying; Li, Jingjing; Cheng, Lin; Kiat Lee, Boon; Peng, Qiaoli; Lu, Xiaofan; An, Minghui; Wang, Hui; Shang, Hong; Zhou, Boping; Wu, Hao; Xu, Aimin; Yuen, Kwok-Yung; Chen, Zhiwei_(*), Gut-homing Delta42PD1(+)Vdelta2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.,Nature Microbiology, 2017.10, 2(10)：1389 ~ 1402 

15.    Yu, Zhe; Tan, Zhiwu_(#); Lee, Boon Kiat; Tang, Jiansong; Wu, Xilin; Cheung, Ka-Wai; Lo, Nathan Tin Lok; Man, Kwan; Liu, Li; Chen, Zhiwei_(*), Antigen spreading-induced CD8(+)T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells, Oncotarget, 2015.10.20, 6(32)：32426 ~ 32438 

16.    Cheng, Lin; Tang, Xian; Liu, Li; Peng, Jie; Nishiura, Kenji; Cheung, Allen Ka Loon; Guo, Jia; Wu, Xilin; Tang, Hang Ying; An, Minghui; Zhou, Jingying; Cheung, Ka Wai; Wang, Hui; Guan, Xinyuan; Wu, Zhiwei_(*); Chen, Zhiwei_(*), Monoclonal antibodies specific to human Delta 42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, mAbs, 2015.5.4, 7(3)：620 ~ 629   

17.    Guo, Jia; Zuo, Teng; Cheng, Lin; Wu, Xilin; Tang, Jiansong; Sun, Caijun; Feng, Liqiang; Chen, Ling; Zhang, Linqi; Chen, Zhiwei_(*), Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region, JAIDS: Journal of Acquired Immune Deficiency Syndromes, 2015.4.15, 68(5)：502 ~ 510  

18.    Chu, Ying; Li, Jiahuang; Wu, Xilin; Hua, Zichun; Wu, Zhiwei_(*), Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340, Journal of Biomedical Science, 2013.7.1, 20 

19.    Yuan, Zhongping; Wu, Xilin; Liu, Chao; Xu, Genxing; Wu, Zhiwei_(*), Asymmetric siRNA: New Strategy to Improve Specificity and Reduce Off-Target Gene Expression, Human Gene Therapy, 2012.5, 23(5)：521 ~ 532

Ø  出版的論著

主持：

國家自然科學基金面上項目

國家自然科學基金青年項目

江蘇省自然科學青年基金項目

江蘇省雙創博士

江蘇省六大人才高峰 B類人才

南京市高層次人才

參與：

國家十三五傳染病重大專項（任務級負責人）

第十五屆江蘇省青年五四獎章集體（排名第一）