金陵醫院（東部戰區總醫院）重症醫學科副主任，在外科危重病及重症急性胰腺炎的綜合救治方面做了大量突破性的創新工作，主要包括：（1）重症急性胰腺炎早期MODS系列防治關鍵技術的建立；（2）重症急性胰腺炎早期腸内營養技術體系的創建；（3）嚴重腹腔感染微創引流技術體系的建立。目前主要的研究方向有：（1）重症急性胰腺炎的臨床和基礎研究；①重症急性胰腺炎早期全身炎症反應和多器官功能障礙的預防和治療；②高甘油三酯血症性胰腺炎特征性的病理生理改變及治療；③急性胰腺炎後糖尿病的發生及發展機制研究。（2）嚴重腹腔感染微創引流體系的優化；（3）危重病患者的營養支持治療和代謝調理；（4）戰創傷患者的無創監測。

全軍重症醫學專業委員會委員兼秘書

中華醫學會重症醫學分會青年委員

中國醫師協會胰腺病分會急性胰腺炎學組委員

中國醫師協會微無創醫學專業委員會胰腺專業委員會委員

中國研究型醫院學會胰腺病分會急性胰腺炎學組委員

江蘇省醫學會重症醫學分會委員

江蘇省醫學會胰腺病分會胰腺炎學組委員

1. Gang Li, Lu Ke, Zhihui Tong, Weiqin Li, Xin Ouyang, Chunbo Chen. Is it necessary for all patients to use prokinetic agents

   to place a trans-pyloric tube? Intensive Care Med,2019 May;45(5):751-752

2. Li G, Gao L, Zhou J, Ye B, Zhang J, Qu C, Ke L, Tong Z, Li W. Management of Splenic Abscess after Splenic Arterial

   Embolization in Severe Acute Pancreatitis: A 5-Year Single-Center Experience. Gastroenterol Res Pract. 2019 Jul

   1;2019:6069179.

3. Ke L, Mao W, Zhou J, Ye B, Li G, Zhang J, Wang P, Tong Z, Windsor J, Li W. Stent-Assisted Percutaneous Endoscopic

   Necrosectomy for Infected Pancreatic Necrosis: Technical Report and a Pilot Study. World J Surg. 2019 Apr;43(4):1121-

   1128. 

4. Gao L, Zhang JZ, Gao K, Zhou J, Li G, Li BQ, Ye B, Ke L, Tong ZH, Li WQ. Management of colonic fistulas in patients with

   infected pancreatic necrosis being treated with a step-up approach. HPB (Oxford). 2020 Apr 26:S1365-182X(20)30108-8.

5. Tu J, Zhang J, Yang Y, Xu Q, Ke L, Tong Z, Li W, Li J. Comparison of pancreatic function and quality of life between

   patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long-term

   study. Exp Ther Med. 2020 Nov;20(5):75

6. Xiaochun Xie,Jie      Dong,Guotao Lu,Kun Gao,Xiaoyao Li,Wenjian Mao,Faxi Chen,Zhihui      Tong,Baiqiang Li,Weiqin Li.

   Increased circulating      total bile acid levels were associated with organ failure in patients with      acute

   pancreatitis. BMC Gastroenterol. 2020 Jul 13;20(1):222

7.       Qu C, Gao L, Yu XQ, Wei M, Fang GQ,      He J, Cao LX, Ke L, Tong ZH, Li WQ. Machine Learning Models of Acute      

         Kidney Injury Prediction in Acute Pancreatitis Patients. Gastroenterol Res      Pract. 2020 Sep 29;2020

8.       Qu C, Zhang H, Chen T, Zhu Y, Feng Q,      Guo F, Liu Z, Cao L, Yang J, Li G, Ye B, Zhou J, Ke L, Tong Z, Windsor J,      Li

         W; Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG). Early on-demand      drainage versus standard

        management among acute necrotizing pancreatitis      patients complicated by persistent organ failure: The protocol for an       open-label multi-center randomized controlled trial. Pancreatology. 2020      Aug 23:S1424-3903(20)30662-1.

9. Qu C, Yu X, Duan Z, Zhou J, Mao W,      Wei M, Cao L, Zhang J, Zhang H, Ke L, Tong Z, Li W. Clinical      characteristics

       and management of gastric outlet obstruction in acute      pancreatitis. Pancreatology. 2021 Jan;21(1):64-68.

10. Ke L, Dong X, Chen T, Doig GS, Li G,      Ye B, Zhou J, Xiao X, Tong Z, Li W; Chinese Acute Pancreatitis      Clinical Trials Group (CAPCTG).  Early on-demand drainage or standard      management for acute pancreatitis patients with acute necrotic collections      and persistent organ failure: A pilot randomized controlled trial. J      Hepatobiliary Pancreat Sci. 2021 Apr;28(4):387-396.

11. Zhang X, Ye B, Mao W, Liu L, Li G,      Zhou J, Zhang J, Guo J, Ke L, Tong Z, Li W. Major adverse kidney      events within 30 days in patients with acute pancreatitis: a      tertiary-center cohort study. HPB (Oxford). 2021 Jun 7:S1365-182X

12. Hao H, Liu Y, Cao J, Gao K, Lu Y,      Wang W, Wang P, Lu S, Hu L, Tong Z, Li W. Genomic New Insights Into      Emergence and Clinical Therapy of Multidrug-Resistant Klebsiella      pneumoniae in Infected Pancreatic Necrosis. Front Microbiol. 2021      Jun 25;12:669230.

13. Dong X, Mao W, Ke L, Gao L, Zhou J,      Ye B, Li G, Phillips A, Tong Z, Windsor J, Li W, Chinese Acute      Pancreatitis Clinical Trials Group Capctg. The Diagnosis and Treatment of      Local Complications of Acute Necrotizing Pancreatitis in China: A National      Survey. Gastroenterol Res Pract. 2021 Jul 10;2021:6611149.

14. Zhou J, Chen W, Liu Y, Qu C, Jiang W,      Yin J, Lin J, Mao W, Ye B, Zhou J, Ke L, Tong Z, Liu Y, Li W.      Trajectories of Lymphocyte Counts in the Early Phase of Acute Pancreatitis      Are Associated With Infected Pancreatic Necrosis. Clin Transl      Gastroenterol. 2021 Sep 22;12(9):e00405.

15. Lu Y, Lu G, Gao L, Zhu Q, Xue J, Zhang      J, Ma X, Ma N, Yang Q, Dong J, Gong W, Li W, Tong Z. The Proresolving      Lipid Mediator Maresin1 Alleviates Experimental Pancreatitis via Switching      Macrophage Polarization. Mediators Inflamm. 2021 Mar 9;2021:6680456. 

16. Cao      L, Zhou J, Chen M, et al. The Effect of Plasma Triglyceride-Lowering      Therapy on the Evolution of Organ Function in Early      Hypertriglyceridemia-Induced Acute Pancreatitis Patients With Worrisome      Features (PERFORM Study): Rationale and Design of a Multicenter,      Prospective, Observational, Cohort Study. Front Med (Lausanne).      2021;8:756337.

17. Shi      X, Hu Y, Pu N, et al. Risk Factors for Fetal Death and Maternal AP      Severity in Acute Pancreatitis in Pregnancy. Front Pediatr.      2021;9:769400.

18. Wei      M, Zhang J, Qu C, et al. The Involvement of Renal Capsule Is Associated      With Acute Kidney Injury in Patients With Acute Pancreatitis. Front      Med (Lausanne). 2021;8:724184

19. Tang      Q, Gao L, Tong Z, Li W. Hyperlipidemia, COVID-19 and Acute Pancreatitis: A      Tale of Three Entities. Am J Med Sci. 2022;S0002-9629(22)00132-X.

20. Ke L,      Lin J, Doig GS, et al. Actively implementing an evidence-based feeding      guideline for critically ill patients (NEED): a multicenter,      cluster-randomized, controlled trial. Crit Care.      2022;26(1):46.

21. Qu C,      Duan Z, Xiao X, et al. Nonthyroidal illness syndrome in acute pancreatitis      patients: an 8-year cohort study. BMC Gastroenterol.      2022;22(1):40.

22. Ke L,      Zhou J, Mao W, et al. Immune enhancement in patients with predicted severe      acute necrotising pancreatitis: a multicentre double-blind randomised      controlled trial. Intensive Care Med. 2022;48(7):899-909.

23. 高堃，童智慧，李維勤. 胰腺壞死組織感染的影像學特征、微創介入方式及時機. 中國實用外科雜志,2019,39(6):575-580.

24. 臯林，童智慧，李維勤. 美國胃腸病協會關于急性胰腺炎胰腺壞死處理臨床實踐專家共識更新解讀. 中國實用外科雜志, 2019,39(12):1257-1264.

25. 高堃，童智慧，李維勤. 膽源性胰腺炎診治難點思考. 中國實用外科雜志, 2020,40(11):1270-1274.

26. 高堃，瞿誠，童智慧，李維勤. 急性胰腺炎的嚴重度評估與重症化預測. 中國實用内科雜志, 2021,41(1):1270-1274.

27. 張敬柱，楊潔，李剛，張和，柯路，周晶，葉博，劉玉秀，童智慧，李維勤. 胰腺壞死組織感染并發十二指腸瘘診治及預後研究. 中國實用外科雜志, 2021,41(3):315-319.

28. 高堃，童智慧，李維勤. 新的治療模式下胰腺壞死組織感染開腹手術指征和時機的思考. 中國普通外科雜志, 2021,30(9):3-9.

1、2013.1-2015.12 膽道壓力的變化在腹腔高壓導緻MODS中的作用及機制探讨，國家自然科學基金青年項目（81200334，經費23萬）

2、2017.1-2020.12 高密度脂蛋白通過SR-B1保護急性胰腺炎腺泡細胞損傷的作用及機制研究，國家自然科學基金面上項目（81670588，經費58萬）

3、2015.7-2018.6 急性胰腺炎規範化診療研究，江蘇省社會發展-重點病種規範化診療診療項目（BE2015685，經費400萬）

4、2016.7-2019.6 胰腺壞死感染微創治療技術體系的建立--階梯式引流新技術，江蘇省重點研發計劃（社會發展）項目（BE2016749，經費400萬）

5、2023.1-2026.12 海藻糖通過IL-17A減輕重症急性胰腺炎損傷的作用及機制研究，國家自然科學基金面上項目（81670588，經費53萬）

 1.重症急性胰腺炎救治關鍵技術的創新與應用，教育部科技進步二等獎，2017年（2/15）

 2.重症急性胰腺炎的實驗和臨床研究，江蘇省科技進步一等獎，2008年（3/9）

3.中華醫學會“第二屆全國普通外科青年醫師獎”、“第二屆重症醫學青年研究獎”、國際胰腺病學會優秀論文三等獎、“黎介壽醫學基金獎”、“江蘇省青年醫學人才”、江蘇省第六期“333高層次人才培養工程”培養對象等。