石雲，教授、博導。生理學博士（佐治亞州立大學），在加州大學舊金山分校藥理學系完成博士後訓練。2013起分别在伟德官网手机版模式動物研究所任教授和課題組長。入選海外青年人才計劃，江蘇省“雙創”人才計劃，獲得江蘇省傑出青年基金資助。主要研究方向為谷氨酸受體的結構、細胞内定位和功能；興奮性突觸的可塑性調節機制；精神和神經疾病的緻病分子機理；新型離子通道的生理功能。主持和參加國家自然基金、科技部項目和省科技廳項目10餘項。近期發現AMPA受體GluA1與Neuroplastin-65的互作在長時程突觸增強中的關鍵作用；闡明谷氨酸受體突變導緻認知障礙的遺傳和突觸機制；解析了Kainate-型谷氨酸受體和輔助亞基的結構；揭示機械敏感TMEM63家族通道的生理功能。發表SCI論文60多篇，部分論文發表在Nature、Mol Psychiatry、PNAS、Neuron、Nature Communications、Cell Reports、eLife等高影響力專業雜志上。

1.Peng SX, Pei J, Rinaldi B, Chen Jiang, Ge YH, Jia M, Wang J, Delahaye-Duriez A, Sun J, Zang YY, Shi YY, Zhang N, Gao X, Milani D, Xu X, Sheng N, Gerard B, Chen Zhang C, Bayat A, Liu N, Yang JJ, Shi YS (2022). Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. Mol Psychiatry. Online ahead of print

2.Li QQ, Chen J, Hu P, Jia M, Sun JH, Feng HY, Qiao FC, Zang YY, Shi YY, Chen G, Sheng N, Xu Y, Yang JJ, Xu Z, Shi YS. (2022) Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. Mol Psychiatry. Online ahead of print.

3.He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y. (2021) Kainate receptor modulation by Neto2. Nature. 599(7884):325-329.

4.Sun JH, Chen J, Ayala Valenzuela FE, Brown C, Masser-Frye D, Jones M, Romero LP, Rinaldi B, Li WL, Li QQ, Wu D, Gerard B, Thorpe E, Bayat A, Shi YS. (2021) X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. PLoS Genet. 17(6):e1009608

5.Jiang CH, Wei M, Zhang C, Shi YS. (2021) The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65. Proc Natl Acad Sci U S A. 118(9):e2019194118.

6.Du H, Ye C, Wu D, Zang YY, Zhang L, Chen C, He XY, Yang JJ, Hu P, Xu Z, Wan G, Shi SY. (2020) The cation channel TMEM63B is an osmosensor required for hearing. Cell Reports. 31:107596.

7.Duan GF, Xu S, Ye Y, Tao W, Nicoll RA, Shi YS, and Sheng N.(2018) Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature Communications. 9(1):4879.

8.Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA. (2018) LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. Proc Natl Acad Sci U S A. 115(15):3948-3953.

9.Sheng N, Shi YS, Nicoll RA. (2017) The amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking.Proc Natl Acad Sci U S A. 114(5):1159-1164.

10.Niu Y, Dai Z, Liu W, Zhang C, Yang Y, Guo Z, Li X, Xu C, Huang X, Wang Y, Shi YS, Liu JJ. (2017) Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. Elife. 6. pii: e20991.

11.He XY, Li YJ, Kalyanaraman C, Qiu LL, Chen C, Xiao Q, Liu WX, Zhang W, Yang JJ, Chen G, Jacobson MP, Shi YS. (2016) GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. Proc Natl Acad Sci U S A. 113(38):E5645-54.

12.Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature. 493(7433)，495-500

13.Herring B, Shi Y, Suh YH, Zheng CY, Schmid SM, Roche KW, Nicoll RA. (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 77(6),1083-96

14.Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. (2011) Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: analysis of single-cell GluN2 subunit deletion in vivo. Neuron. 71(6), 1085-1101

15.Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A. 107(37), 16315-16319

16.Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron. 62(5), 633-40

17.Lu W, Shi Y, Jackson A, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron. 62(2), 254-68

2022-2025   自然科學基金委面上項目，Neuroplastin調控興奮/抑制性突觸傳遞和可塑性的機制研究，主持

2020-2024   科技部重大科技專項， 大腦組織中神經與血管偶聯發育及血腦屏障建立和穩态維持的調控機制，主持

2019-2022   江蘇省社會發展-重點項目-臨床前沿技術，精神分裂症動物模型的快速構建和精準治療的研究，主持

2019     中央高校基金，新型離子通道的功能研究，主持

2019-2021   自然科學基金委重大研究計劃培育項目，谷氨酸受體調節亞基TARP g-8缺失導緻精神分裂樣腦衰老的機制研究，主持

2017      中央高校科研業務專項基金，突觸可塑性的分子細胞機制，主持

2016-2017   自然科學基金委面上, 神經活動對AMPA受體mRNA剪接和突觸可塑性的影響，主持

2015-2017   國家科技支撐計劃, 大鼠等基因工程動物人類疾病模型研究與服務體系構建，參加

2014-2017   江蘇省雙創人才

2014-2017   江蘇省傑青, 突觸可塑性機制研究, 主持

2014-2018   科技部973重大項目, 神經元遷移、形态發生和微環路形成的調控機制, 參加

2014-2017   自然科學基金委面上項目, Neto蛋白對kainate-型谷氨酸受體的突觸定位和功能的調節作用, 主持

2021“中國神經科學----2021年度重大進展”獎

2014  江蘇省雙創人才

2014  江蘇省傑出青年

2007  佐治亞州立大學傑出研究獎