主要從事精子發生調控，男性性功能障礙，男性生殖道感染，環境與基因交互作用對人群生殖能力影響的臨床及基礎研究；注重“中西并重”，在中西醫結合診療男科疾病上經驗豐富；重視臨床經驗的成果轉化，結合臨床實踐，申請多項發明專利及實用新型專利；注重基礎研究向臨床應用的轉化。作為項目負責人主持國家重點研發計劃項目1項，國家自然科學基金3項，省部級課題多項。以第一作者/通訊作者發表論文100餘篇，SCI論文30餘篇。主編專業著作6部，主編科普著作4部，副主編、參編著作20餘部。

[1]Man Yonghong,ShangXuejun,LiuChunyu,ZhangWei,HuangQian,MaSuheng,ShiangRita,ZhangFeng,ZhangLing,ZhangZhibing. Whole-Exome Sequencing Identifies the VHL Mutation (c.262T > C, p.Try88Arg) in Non-Obstructive Azoospermia-Associated Cystic Renal Cell Carcinoma[J]. Current Oncology,2022,29(4).共同第一作者

[2]Li Jiajia,LinShiqi,WuJilei,LiYu,ShangXuejun,PeiLijun. Spatial variation and association between maternal chemical fertilizer exposure and preterm birth in a rural area in Northern China.[J]. Environmental science and pollution research international,2021,29(13).通訊作者

[3]Qu Mengyuan,FengChenzhao,WangXiaotong,GuYiqun,ShangXuejun,ZhouYuanzhong,XiongChengliang,LiHonggang. Association of Serum Testosterone and Luteinizing Hormone With Blood Pressure and Risk of Cardiovascular Disease in Middle-Aged and Elderly Men.[J]. Journal of the American Heart Association,2021,10(7).通訊作者

[4]WeiningLiang,ZhigangWu,GuoweiZhang,WeikangChen,XiangnongHu,JianjunYang,JieMeng,YanZeng,HongjunLi,Xuejun Shang. A urine-based biomarker for chronic prostatitis/chronic pelvic pain syndrome: a retrospective multi-center study[J]. Translational Andrology and Urology,2020,9(5).通訊作者

[5]Zhang Kaishu,FuLonglong,AnQi,HuWeihong,LiuJianxin,TangXiuming,DingYu,LuWenhong,LiangXiaowei,ShangXuejun,GuYiqun. Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia.[J]. BMC complementary medicine and therapies,2020,20(1).通訊作者

[6]CaiHongcai,QingXingrong,Niringiyumukiza Jean Damascene,ZhanXuxin,MoDunsheng,ZhouYuanzhong,ShangXuejun. CFTR Variants and Renal Abnormalities in Males With Congenital Unilateral Absence of the Vas Deferens (CUAVD):A Systematic Review and Meta-analysis of Observational Studies[J]. Obstetrical & Gynecological Survey,2019,74(9).通訊作者

[7]Yu Lisha,YangXiaojing,MaBo,YingHanjie,ShangXuejun,HeBingfang,Zhang Qi. Abnormal arachidonic acid metabolic network may reduce sperm motility via P38 MAPK.[J]. Open biology,2019,9(4).通訊作者

[8]Lv Bi-Hua,TanWei,Zhu Chang-Cai,ShangXuejun,Zhang Ling. Properties of a Stable and Sustained-Release Formulation of Recombinant Human Parathyroid Hormone (rhPTH) with Chitosan and Silk Fibroin Microparticles.[J]. Medical science monitor : international medical journal of experimental and clinical research,2018,24.通訊作者

近5年主要研究課題如下：

1基于内外暴露監測的環境和行為因素對胚胎發育與妊娠影響研究，國家重點研發計劃，項目編号2018YFC1004300（2018.18-2022.12），在研，項目負責人。

2電生理适宜技術在男科疾病防治的應用，國家科技計劃項目（2021），項目編号HDSL202001049（2021.06-2023.06），在研，合作單位負責人。

3炎症抑制FABP9/12導緻脂肪酸代謝障礙影響精子發生的機制研究，國家自然科學基金，項目編号81771646（2018.01-2021.12），結題，主持。

4左卡尼汀在脂多糖有到達數脂肪酸代謝紊亂導緻生精障礙中的保護機制研究，江蘇省“六大人才高峰”項目，項目編号WSN-069（2018.01-2020.12），結題，主持。

5男性軍人慢性前列腺炎與不育症精準診療研究及生育力保存機制探讨，軍隊計生專項研究任務計劃，項目編号17JS013，結題，主持。