本碩博畢業于海軍軍醫大學，任中華醫學會泌尿外科分會基礎學組委員，江蘇省抗癌協會泌尿男生殖系專業委員會委員，《國際泌尿系統雜志》及《Clinical Genitourinary Cancer》編委，教育部青年長江學者，江蘇省傑出青年基金獲得者。長期聚焦腎髒腫瘤的精準診療和轉化研究，以第一或通訊作者在Cancer Cell、European Urology、Nature Communications、Science Advances等雜志發表SCI論文17篇，并獲國家發明專利授權5項。獲全軍優秀博士論文，中國醫師協會年度最佳臨床研究論文獎，教育部科技進步獎一等獎和國家科學技術進步獎二等獎項。主持國家自然科學基金面上項目、博士後創新人才支持計劃，江蘇省六大人才高峰等課題，作為學術骨幹參與國家重點研發計劃。受英國皇家外科學院邀請，參編英文專著《Kidney cancer》。

中華醫學會泌尿外科分會基礎學組委員

江蘇省抗癌協會泌尿男生殖系專業委員會委員

（1）Le Qu^#, Jin Ding^#, Cheng Chen^#, Zhenjie Wu^#, Bing Liu^#, Yi Gao, Wei Chen, Feng Liu, Wen Sun, Xiaofeng Li, Xue Wang, Yue Wang, Zhenyu Xu, Li Gao, Qing Yang, Bin Xu, Yaoming Li, Ziyu Fang, Zhipeng Xu, Yi Bao, Dengshuang Wu, Xiong Miao, Haiyang Sun, Yinghao Sun, Hongyang Wang*, Linhui Wang*, Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-668. (IF: 31.743)

（2）Le Qu^#/*, Zelin Wang^#, Qi Chen^#, Yaoming Li^#, Haowei He^#, James J Hsieh, Song Xue, Zhenjie Wu, Bing Liu, Hao Tang, Xiaofeng Xu, Feng Xu, Jie Wang, Yi Bao, Anbang Wang, Dong Wang, Xiaoming Yi, Zhongkui Zhou, Changjie Shi, Ke Zhong, Zhengcheng Sheng, Yulin Zhou, Jun Jiang, Xiaoyuan Chu, Jia He, Jingping Ge, Zhengyu Zhang, Wenquan Zhou*, Cheng Chen*, Jianhua Yang*, Yinghao Sun*, Linhui Wang*. Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma. European Urology. 2018 Dec;74(6):756-763. (IF: 24.267)

（3）Zhenjie Wu^#, Qi Chen^#, Le Qu*, Mingmin Li*, Linhui Wang*, Maria C. Mir, Umberto Carbonara, Savio D. Pandolfo, Peter C. Black, Asit K Paul, Giuseppe Di Lorenzo, Francesco Porpiglia, Andrea Mari, Andrea Necchi, Morgan Roupret, Sarah P. Psutka, Riccardo Autorino. Adverse Events of Immune Checkpoint Inhibitors therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-Analysis. European Urology. 2022 Jan 28;S0302-2838(22)00065-3. (IF: 24.267)

（4）Yicun Wang^#, Jinhui Wu^#, Hui Chen^#, Yang Yang^#, Chengwu Xiao^#, Xiaoming Yi^#, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang , Xiaodie Zhou , Gwen Lomberk , Bing Liu , Jianning Zhao , Jingping Ge, Wenquan Zhou*, Xiaoyuan Chu*, Cheng Chen*, Xuhui Zhou*, Linhui Wang*, Kunliang Guan, Le Qu*. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Science Advances. 2021 Jan 27; EABE3445 (IF: 14.957)

（5）Le Qu^#, Zhenjie Wu^#, Yaoming Li^#, Zhipeng Xu^#, Bing Liu, Feng Liu, Yi Bao, Dengshuang Wu,Jiayi Liu, Anbang Wang, Xiaoyuan Chu, Yinghao Sun, Cheng Chen*, Zhengyu Zhang*, Linhui Wang*. A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells. Nature Communications. 2016 Nov 25;7:12692. (IF: 17.694)

（6）Zhipeng Xu^#, Fu Yang^#, Dan Wei^#, Bing Liu, Cheng Chen, Yi Bao, Zhenjie Wu, Dengshuang Wu, Haisong Tan, Jiakuan Li, Jie Wang, Jiayi Liu, Shuhan Sun*, Le Qu*, Linhui Wang*. Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. Oncogene. 2017 Apr 6;36(14):1965-1977. (IF: 8.756)

（7）Anbang Wang^#, Le Qu*, Linhui Wang*, At the crossroads of cancer stem cells and targeted therapy resistance. Cancer Letters. 2017 Jan 28;385:87-96. (IF: 9.756)

（8）Anbang Wang^#, Yi Bao^#, Zhenjie Wu^#, Tangliang Zhao^#, Dong Wang^#, Jiazi Shi, Bing Liu, Shuhan Sun, Fu Yang*, Linhui Wang*, Le Qu*. Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. Cell Death Disease. 2019 Feb 15;10(3):154. (IF: 9.685)

（9）Yi Bao^#, Fu Yang^#, Bing Liu^#, Tangliang Zhao^#, Zhipeng Xu^#, Ying Xiong, Shuhan Sun*, Le Qu* and Linhui Wang*. Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response. British journal of cancer. 2018 Aug;119(4):450-461. (IF: 9.075)

（10）Jiakuan Li^#, Cheng Chen^#, Jiayi Liu^#, Jiazi Shi^#, Shupeng Liu^#, Bing Liu, Dengshuang Wu, Ziyu Fang, Yi Bao, Mingming Jiang, Jihang Yuan*,Le Qu*, Lin-Hui Wang*. Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling. Molecular Cancer. 2017 Jun 28;16(1):111. (IF: 41.444)

（11）Dengshuang Wu^#, Cheng Chen^#, Zhenjie Wu^#, Bing Liu, Li Gao, Qing Yang, Wei Chen, Junming Chen, Yi Bao, Le Qu*, Linhui Wang*. ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma. Journal of Experimental & Clinical Cancer Research. 2016 Jul 4;35(1):108. (IF: 9.867)

（12）Bowen Du^#, Yulin Zhou^#, Xiaoming Yi, Tangliang Zhao, Chaopeng Tang, Tianyi Shen, Kai Zhou, Huixian Wei, Song Xu*, Jie Dong*, Le Qu*, Haowei He* and Wenquan Zhou. Identification of Immune-Related Cells and Genes in Tumor Microenvironment of Clear Cell Renal Cell Carcinoma. Frontiers in Oncology, 2020, 10: 1770. (IF: 12.658)

（13）Aimin Jiang^#, Jialin Meng^#, Wenliang Gong^#, Zhonghua Zhang^#, Xinxin Gan, Jie Wang, Zhenjie Wu, Bing Liu*, Le Qu*, Linhui Wang*. Elevated SNRPA1, as a promising predictor reflecting severe clinical outcome via effecting tumor immunity for ccRCC, is related to cell invasion, metastasis and Sunitinib sensitivity. Frontiers in Immunology. 2022; February; 13; fimmu.2022.842069 (IF: 8.786)

（14）Zhipeng Xu^#, Peng Li^#, Dan Wei^#, Zhixiang Wang, Yi Bao, Jipeng Sun, Le Qu*, Linhui Wang*. NMMHC-IIA-dependent nuclear location of CXCR4 promotes migration and invasion in renal cell carcinoma. Oncology Reports. 2016 Nov;36(5):2681-2688. (IF: 4.136)

（15）Xiao-Feng Li^#, Cheng Chen^#, Dai-Min Xiang^#, Le Qu#, Wen Sun, Xin-Yuan Lu, Teng-Fei Zhou, Shu-Zhen Chen, Bei-Fang Ning, Zhuo Cheng, Ming-Yang Xia, Wei-Feng Shen, Wen Yang, Wen Wen, Terence Kin Wah Lee, Wen-Ming Cong, Hong-Yang Wang*, Jin Ding*. Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance. Hepatology. 2017 Dec;66(6):1934-1951. (IF: 17.298)

1. 國家自然科學基金面上項目，82173345，2022/01-2025-12。

2. 國家自然科學基金面上項目，81772740，2018/01-2021-12。

3. 江蘇省傑出青年基金項目，BK20200006，2020/07-2023/06。

4. 江蘇省自然科學基金青年基金，BK20170621，2017/07-2020/06。

5. 江蘇省第十六批“六大人才高峰”高層次人才，YY-093，2020/01-2022/12。

6. 博士後創新人才支持計劃，BX201700105，2017/05-2019/05。

7. 中國博士後科學基金面上項目，2018M643886，2018/07-2019/06。

8. 江蘇省博士後科研資助計劃，2018K289C，2018/01-2020/01。

2020年  江蘇省傑出青年基金項目

2019年  教育部“長江學者獎勵計劃”青年學者

2019年  江蘇省“六大人才高峰”高層次人才

2018年  國家科學技術進步獎，二等獎（第三完成人）

2017年  教育部科技進步獎，一等獎（第六完成人）

2016年  全軍優秀博士論文