Guiquan obtained his Ph.D. in Neuroscience from the University of Edinburgh in Scotland in 2005, and then conducted his postdoctoral research at Harvard Medical School in Boston. He joined the Model Animal Research Center of Nanjing University as a Principle Investigator in December of 2011. His long-term research goal is to understand molecular mechanisms by which the γ–secretase complex regulates neuronal survival and/or death. His lab combines techniques of mouse genetics, molecular biology, cellular and behavioral neuroscience to address this question. Elucidation of molecular mechanisms for age-related neurodegeneration may help to identify novel therapeutic targets for the prevention and treatment of neurodegenerative diseases.