林兆宇博士，2006-2012年在南京大學模式動物研究所攻讀博士學位，師從高翔教授，并在美國聖路易斯華盛頓大學進行3年訪問學者研究。回國後2012-2013年在南京大學化學化工學院進行博士後研究；2014年加入模式動物研究所任副研究員；2019年受聘為南京大學副教授，醫藥生物技術國家重點實驗室研究員。

本課題組專注于生理穩态的免疫和代謝調控。由于免疫和代謝涉及幾乎所有的核心生理穩态調控，所以其調控紊亂是自身免疫、肥胖、不孕不育、腫瘤、心血管和老年癡呆等多種複雜疾病的重要原因。本課題組希望從分子機制角度解釋免疫和代謝紊亂導緻的複雜疾病的症狀，并探尋疾病臨床治療靶點和方法。圍繞着生理穩态的免疫和代謝調控本課題組開展了以下三方面的研究内容：

(一) 固有免疫中細胞焦亡與相關自身疾病（膿毒症、矽肺、哮喘和銀屑病等）的發病機制研究和治療方法開發

(二) 機體代謝紊亂（肥胖）的調控機制研究與相應減肥療法的開發

(三) 基于腸道菌群人源化小鼠模型研究炎症性腸病和結腸癌的發病機制和治療方法

1. Zhao,M., K. Ren, X. Xiong, Y. Xin, Y. Zou, J.C. Maynard, A. Kim, A.P. Battist, N. Koneripalli, Y. Wang, Q. Chen, R. Xin, C. Yang, R. Huang, J. Yu, Z. Huang, Z. Zhang, H. Wang, D. Wang, Y. Xiao, O.C. Salgado, N.N. Jarjour, K.A. Hogquist, X.S. Revelo, A.L.Burlingame, X.  Gao, J. von Moltke, Z. Lin*, and H.B.Ruan*, Epithelial  STAT6 O-GlcNAcylation drives a concertedanti-helminth alarmin  response dependent on tuft cell hyperplasiaand Gasdermin C. Immunity, 2022. 55(4): p. 623-638.e5.

2.Chen,Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z.Lin*,  Nitrosonisoldipine is a selective inhibitor ofinflammatory caspases  and protects against pyroptosis and relatedseptic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.

3. Zou,D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang,  Y.Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z.Lin*,  A SNP of bacterial blc disturbs gut lysophospholipidhomeostasis and  induces inflammation through epithelial barrierdisruption. EBioMedicine, 2020. 52: p. 102652.

4. Wang,D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou,  D.Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*,Magnesium protects against sepsis by blocking gasdermin DN-terminal-induced pyroptosis. Cell Death Differ, 2020.27(2): p. 466-481.

5.Sun,M., S. Zheng, X. Gao*, and Z. Lin*, The role ofimmune cells in obesogenic memory. Cell Mol Immunol, 2020.17(8): p. 884-886.

6.Wang,Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z.Lin*, Mitochondrial ROS promote macrophage pyroptosis byinducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p.1069-1082.

7.Chen,Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z.Huang, J. Ren, Z. Lin*, and X. Gao*, GSDMB promotesnon-canonical pyroptosis by enhancing caspase-4 activity. J MolCell Biol, 2019. 11(6): p. 496-508.

8.Chen,Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X.Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.

9.Zou,J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P.Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*,CD4+ T cells memorize obesity and promote weight regain. CellMol Immunol, 2018. 15(6): p. 630-639.

10.Lin,Z.*,  F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen,J. Li, and X.  Gao, Fatty acid oxidation promotes reprogramming byenhancing  oxidative phosphorylation and inhibiting protein kinaseC. Stem Cell Res Ther, 2018. 9(1): p. 47.