教育和工作經曆：

2007年8至今 伟德官网手机版講師、副教授、教授

2013年11月—2014年11月，美國國立衛生院腫瘤研究中心 訪學學者

2007年6月 獲南京大學理學博士學位

1997年6月 獲南京醫科大學臨床醫學學士學位

教學：

首批江蘇省一流本科課程、南京大學“百”層次優質課程《組織學和胚胎學》課程負責人和主講教師，公選課《人工智能推動微觀形态精準觀察》、《人類生殖與胚胎發生》課程負責人。

研究生課程《生殖生物學》負責人，《組織病理學》和《疾病研究的生物學方法》等研究生課程主講教師。

江蘇省解剖學會 理事

江蘇省解剖學會第十二屆理事會組織胚胎學專業委員會 委員

江蘇省高等學校醫藥教育研究會 理事

江蘇省高等學校醫藥教育研究會-醫學人文素質教育專業委員會 理事

江蘇省醫學會男科分會 委員

《中華男科學》雜志 編委

南京口腔醫學會 副理事長

泌尿系腫瘤相關、環境毒理類、公共健康類SCI雜志審稿專家

2018年以來通訊作者論文：

37.    Xia Y, Chen Y, Chen J, Han X, Wang J, Li D. Gestational exposure to a fluorotelomer alcohol causes behavioral abnormalities by disrupting the blood–brain barrier in offspring. Environ Chem Lett (2024). https://doi.org/10.1007/s10311-024-01707-5

36. Chen J, Xia Y, Ben Y, Lu X, Dou K, Ding Y, Han X, Yang F, Wang J, Li D. Embryonic exposure to aluminum chloride blocks the onset of spermatogenesis through disturbing the dynamics of testicular tight junctions via upregulating Slc25a5 in offspring. Sci Total Environ.2024 Jan 17;915:170128.

35. Chen Y, Lu Y, Yang L, Ma W, Dong Y, Zhou S, Liu N, Gan W, Li D. LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner. J Exp Clin Cancer Res.2023 Sep 28;42(1):252.

34.Li L, Xia Y, Chen J, Han X, Hao L, Li D, Liu Y. DBP exposure induces thyroid inflammatory impairment through activating AKT/NF-κB/NLRP3 signaling. Ecotoxicol Environ Saf. 2023 Aug 23;264:115385. 

33. Xia Y, Hao L, Li Y, Li Y, Chen J, Li L, Han X, Liu Y, Wang X, Li D. Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice. Ecotoxicol Environ Saf. 2023 Jan 15;250:114497.

32.Ma T, Xia Y, Wang B, Yang F, Ding J, Wu J, Han X, Wang J, Li D. Environmentally relevant perinatal     exposure to DBP accelerated spermatogenesis by promoting the glycolipid metabolism of Sertoli cells in male offspring mice.Toxicol Lett. 2023 Mar 15;377:16-28.

31.Ma W, Li X, Yang L, Pan J, Chen Y, Lu Y, Dong X, Li D, Gan W. High VSX1 expression promotes the     aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10. J Transl Med.  2022 Dec 3;20(1):554. 

30. Yang L, Yin H, Chen Y, Pan C, Hang H, Lu Y, Ma W, Li X, Gan W, Guo H, Li D. Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA. Exp Hematol Oncol. 2022 Nov 8;11(1):87.

29.Yang L, Chen Y, Liu N, Lu Y, Li X, Ma W, Gan W, Li D. 5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma. Biomark Res. 2022 Jul 27;10(1):54.

28.Liu N, Chen Y, Yang L, Shi Q, Lu Y, Ma W, Han X, Guo H, Li D, Gan W. Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma. Clin Transl Med. 2022 Apr;12(4):e797.

27.Chen Y, Yang L, Lu Y, Liu N, Ma W, Fan H, Hu Q, Han X, Gan W, Li D. Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma. Cancer Lett. 2022 Jul 10;538:215689.

26.Xia Y, Chen J, Ma T, Meng X, Han X, Li D. Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway. Sci Total Environ. 2022 Mar 8:154437.

25.Yang L, Chen Y, Liu N, Lu Y, Ma W, Yang Z, Gan W, Li D. CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3. Mol Cancer. 2022 Jan 18;21(1):23.

24.Shi Q, Liu N, Yang L, Chen Y, Lu Y, Guo H, Han X, Li D, Gan W. Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma. Cell Commun Signal. 2021 Nov 16;19(1):114.

23.Wang B, Yin X, Gan W, Pan F, Li S, Xiang Z, Han X, Li D. PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma. Autophagy. 2021 Sep;17(9):2475-2493.

22.Chen Y, Yang L, Liu N, Shi Q, Yin X, Han X, Gan W, Li D. NONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting HIF1A in NONO-TFE3 Translocation Renal Cell Carcinoma. Curr Cancer Drug Targets. 2021;21(8):713-723.

21.Ma T, Zhou Y, Xia Y, Jin H, Wang B, Wu J, Ding J, Wang J, Yang F, Han X, Li D. Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice. Toxicology. 2021 Jul 16;459:152860.

20.Yang L, Chen Y, Liu N, Shi Q, Han X, Gan W, Li D. Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN. J Hematol Oncol. 2021 Mar 19;14(1):46.

19.Wang B, Gan W, Han X, Liu N, Ma T, Li D. The positive regulation loop between NRF1 and NONO-TFE3 fusion promotes phase separation and aggregation of NONO-TFE3 in NONO-TFE3 tRCC. Int J Biol Macromol. 2021 Feb 13; 176:437-447.

18.Shi Q, Liu N, Zhu Y, Qu F, Xu L, Li X, Zhang G, Guo H, Li D, Gan W. A new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults. J Int Med Res. 2021 Mar;49(3):300060521997661.

17.Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy. 2021 Feb;17(2):457-475.

16.Zhang L, Meng X, Li D, Han X. piR-001773 and piR-017184 promote prostate cancer progression by interacting with PCDH9. Cell Signal. 2020 Dec;76:109780.

15.Zhu Y, Liu N, Guo W, Pu X, Guo H, Gan W, Li D. ALK rearrangement in TFE3-positive renal cell carcinoma: Alternative diagnostic option to exclude Xp11.2 translocation carcinoma. Pathol Res Pract. 2020 Dec;216(12):153286.

14.Liu N, Guo W, Shi Q, Zhuang W, Pu X, Chen S, Qu F, Xu L, Zhao X, Li X, Zhang G, Guo H, Gan W, Li D. The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma. Sci Rep. 2020 Oct 1;10(1):16361.

13.Ma T, Zhou Y, Xia Y, Meng X, Jin H, Wang B, Chen Y, Qiu J, Wu J, Ding J, Han X, Li D. Maternal Exposure to Di-n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE2/MMP-2 in Mouse Offspring. Environ Sci Technol. 2020 Jul 7;54(13):8245-8258.

12.Ma T, Hou J, Zhou Y, Chen Y, Qiu J, Wu J, Ding J, Han X, Li D. Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2. Environ Health. 2020 Aug 1;19(1):87.

11.Meng X, Zhang L, Hou J, Ma T, Pan C, Zhou Y, Han R, Ding Y, Peng H, Xiang Z, Li D, Han X. The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)-paternal-exposed offspring mice. Sci Total Environ. 2020 Sep 20; 736:139678.

10.Xia Y, Ma T, Ji J, Zhang L, Wang Y, Wu J, Ding J, Han X, Li D. In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice. Ecotoxicol Environ Saf. 2020 Jul 15;198:110698.

9.Wang B, Gan W, Han X, Li D. PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission. Cell Biol Int. 2020 Aug;44(8):1727-1733.

8.Zhang L, Meng X, Pan C, Qu F, Gan W, Xiang Z, Han X, Li D. piR-31470 epigenetically suppresses the expression of glutathione S-transferase pi 1 in prostate cancer via DNA methylation. Cell Signal. 2020 Mar;67:109501.

7.Zhou Y, Ma T, Yan M, Meng X, Wu J, Ding J, Han X, Li D. Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes. Sci Total Environ. 2020 Mar 10;707:136139.

6.Han R, Zhang L, Gan W, Fu K, Jiang K, Ding J, Wu J, Han X, Li D. piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate. 2019 May;79(7):798-812.

5.Yin X, Wang B, Gan W, Zhuang W, Xiang Z, Han X, Li D. TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. J Exp Clin Cancer Res. 2019 Mar 8;38(1):119.

4.Liu N, Gan W, Qu F, Wang Z, Zhuang W, Agizamhan S, Xu L, Yin J, Guo H, Li D. Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?: A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.

3.Zhang L, Meng X, Xiang Z, Li D, Han X. From the Cover: Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis. Toxicol Sci. 2018 Jan 1;161(1):159-170.

2.Yin X, Ma T, Han R, Ding J, Zhang H, Han X, Li D. MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)-induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018 Mar;47:79-88.

1.Chen Y, Wang J, Pan C, Li D, Han X. Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cell Mol Life Sci. 2018 Mar;75(6):1117-1132.

國家自然科學基金面上項目（42477460）

國家自然科學基金面上項目（31971517）

國家自然科學基金面上項目（21377052）

國家自然科學基金青年項目（30800115）

江蘇省自然科學基金（BK20221444）

江蘇省自然科學基金（BK20131281）

江蘇省自然科學基金（BK2010367）

江蘇省第八批“六大人才高峰”高層次人才培養對象項目（衛生行業2011-WS070）

教育部新青年教師基金（200802841006）

南京大學技術創新基金項目：Xp11.2易位型腎癌分子診斷模型的建立

生命分析化學國家重點實驗室自主研究課題（5431ZZXM2004）：Xp11.2易位型腎癌分子診斷模型的建立

2023年 江蘇省“優秀博士學位論文”指導教師

2023年 南京大學“師德先進”團隊——人體解剖與組織胚胎學科教師團隊成員

2023年 南京大學“優秀博士學位論文”指導教師

2022年 南京大學“優秀博士學位論文”指導教師

2022年 伟德官网手机版優秀教師

2020年 伟德官网手机版優秀博士生導師

2020年 南京大學“魅力導師獎”

2019年 江蘇省高校微課教學比賽 三等獎

2018年 江蘇省教育教學與研究成果獎（研究類）三等獎

2018年 南京大學“魅力導師獎”

2017年 華東地區青年學者高峰論壇青年學者獎

2017年 南京大學教學成果獎

2016年 南京大學創新育人獎

2015年 伟德官网手机版優秀教師