甘振繼
教授
電話：025-58641546郵箱：ganzj@nju.edu.cn 地址：研究方向：

線粒體，骨骼肌，代謝疾病分子機制
  • 個人簡介
  • 學術兼職
  • 代表性論文
  • 承擔科研項目
  • 獲獎情況

甘振繼，南京大學教授，博士生導師，國家傑青，國家優青，國家海外高層次人才，江蘇省“雙創”人才。曾獲得美國心髒學會Louis and Arnold Katz Basic Science Award，中國生物物理學會代謝生物學分會“青年科學家獎”。博士畢業于中科院上海生命科學研究院，曾在美國Sanford-Burnham醫學研究所從事科研工作，長期緻力于骨骼肌的生理調控規律研究，取得系統性重要成果。以通訊作者在Nat Cell Biol.、Sci Transl Med.、J Clin Invest.、J Exp Med.、Nat Commun.、Sci Adv.、PNAS.等主流學術期刊發表研究論文20餘篇，并受邀在Cell Res.撰寫相關綜述。研究成果為加深理解骨骼肌穩态調節在代謝健康中的生理學作用和機制提供了新的理論線索，得到國内外同行的廣泛關注和認可。

中國生物物理學會代謝生物學分會青年理事秘書長

中國病理生理學會内分泌與代謝分會副秘書長

中國細胞生物學學會細胞代謝分會理事

中國生物物理學會線粒體生物學分會理事

中國細胞生物學學會細胞結構與細胞行為分會理事

中國生化與分子生物學學會代謝分會理事

為Dev Cell.、J Clin Invest.、Nat Commun.、Cell Rep.、Cell Death Differ.、J Cachexia Sarcopenia Muscle.、Autophagy、Aging Cell、EMBO Rep、FASEB J. 等學術期刊審稿


代表性成果：

  1. Mao Y#, Jin Z#, Yang J, Xu D, Zhao L, Kiram A, Yin Y, Zhou D, Sun Z, Xiao L, Zhou Z, Yang L, Fu T, Xu Z, Jia Y, Chen X, Niu FN, Li X*, Zhu Z*, Gan Z*. Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse.Sci Transl Med. 16(750): eadk9811.

  2. Xiao L#, Yin Y#, Sun Z#, Liu J#, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X* and Gan Z*.AMPK phosphorylation of FNIP1 (Ser220) controls mitochondrial function and muscle fuel utilization during exercise. Science Advances. 2024; 10(6): eadj2752. 

  3. Fu T #, Sun W#, Xue J#, Zhou Z#, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Philipp E. Scherer, Fang L, Piao HL, Shao M* and Gan Z*. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switch of adipocytes. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01155-3.

  4. Gan Z* and Shao M. Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover. Nat Cell Biol. 2023; doi: 10.1038/s41556-023-01161-5.

  5. Guo Q#, Xu Z#, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z*. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.Science Advances. 2022; 8(30): eabo0340.

  6. Yin Y, Xu D, Mao Y, Gan Z*. Comments on 'FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics'. J Mol Cell Biol. 2022; mjac033.

  7. Yin Y#, Xu D#, Mao Y#, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z*. FNIP1 regulates white adipose tissue browning and systemic glucose homeostasis by shaping intracellular calcium dynamics.J Exp Med. 2022; 219(5): e20212491.

  8. Xu Z#, Fu T#, Guo Q#, Zhou D, Sun W, Zhou Z, Chen X, Zhang Z, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu M, Fei W, Lu B, Gan Z*. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat Commun. 2022; 13(1):894.

  9. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest. 2021;131(17): e143737.

  10. Xiao L#, Liu J#, Sun Z#, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X, Gan Z*. AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.PLoS Genet.2021; 17(3): e1009488.

  11. Liu L#, Ding C#, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z*. Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest. 2020, 130(9):4710-4725.

  12. Liu L#, Cai J#, Wang H#, Liang X#, Zhou Q#, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*.Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785.

  13. Xu Z, Fu T, Guo Q, Sun W, Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.Pharmacol Res. 2018; 141:176-180.

  14. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research. 2018; 28(10): 969-980.

  15. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose crosstalk to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372.

  16. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med.2016; 8(10):1212-1228. Cover story.

  17. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR, Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J. Biol. Chem.2016; 291(49):25306-25318.

  18. Liu J, Liang X, Gan Z*. Transcriptional regulatory circuits controlling muscle fiber type switching. Sci China Life Sci.2015; 58(4):321-7.

  19. Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; 123(6):2564-75.

  20. Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARb/d programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25(24):2619-30.

  21. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem.2006; 281(44):33386-94.


  1. 江蘇省基礎研究計劃（自然科學基金），BK20140600，2014-2016、主持人，已結題;

  2. 國家“海外高層次青年人才”，2015-2017、主持人，已結題;

  3. 國家重點基礎研究發展計劃（973計劃），2015CB856300，2015-2019、學術骨幹，已結題;

  4. 國家自然科學基金面上項目，31471110，2015-2018、主持人，已結題;

  5. 國家自然科學青年科學基金，81400821，2015-2017、主持人、已結題;

  6. 江蘇省雙創計劃-人才項目，2017-2019、主持人，已結題;

  7. 江蘇省自然科學基金傑出青年基金項目，BK20170014，2017-2019、主持人，已結題;

  8. 國家自然科學基金面上項目，31771291，2018-2021、主持人，已結題;

  9. 國家自然科學基金重大研究計劃，91857105，2019-2021、主持人，已結題;

  10. 國家重點研發計劃，2018YFA0800704，2019-2024、課題組長，在研;

  11. 國家自然科學優秀青年科學基金，31922033，2020-2022、主持人，已結題;

  12. 江蘇省“六大高峰人才”高層次人才項目，2019-2022、主持人，已結題;

  13. 國家重點研發計劃，2022YFA0806003，2022-2027、課題骨幹，在研;

  14. 國家自然科學傑出青年科學基金，32425019，2025-2029、主持人，在研。


美國心髒學會（AHA）博士後獎

美國心髒學會Katz基礎研究青年學者獎(Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigator)

國家海外高層次人才項目入選者

江蘇省“雙創人才”

江蘇省“傑出青年”

國家基金委“優青”

中國生物物理學會代謝生物學分會“青年科學家獎”

國家基金委“傑青
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