李顔

姓名

李顔

研究方向：

免疫學/

人源化小鼠模型

聯系方式

yanli@nju.edu.cn

學術兼職：

國際人源化小鼠大會(IWHM)科學委員會成員

中國細胞生物學會免疫細胞分會委員

中國醫藥生物技術協會-疾病模型分會委員

中國抗癌協會腫瘤免疫代謝分會委員

江蘇省細胞與發育生物學學會理事

Frontiers in Immunology人源化小鼠專刊副主編

個人簡介

李顔博士，伟德官网手机版教授/醫藥生物技術國家重點實驗室研究員, 國家重點研發計劃青年項目首席（原青年973首席），國自然基金委優青，江蘇省“雙創團隊領軍人才”，“省特聘教授”。研究關注小鼠模型與人體的物種差異，為加速基礎生物學發現向臨床疾病治療的轉化，本課題組研發了一系列小鼠品系和實驗方法，将人免疫系統與多種人體組織嵌合到小鼠中，解決傳統小鼠模型與臨床試驗難以回答的科學問題。當前課題組方向包括：（1）新型免疫人源化小鼠模型；（2）人體器官+免疫雙人源化小鼠模型；（3）腫瘤及自身免疫系統疾病的免疫治療；（4）人體免疫細胞發育及功能。其研究成果發表在Cell，Nature Methods，Nature Communications，Science Advances等期刊，申報獲得多項國内專利，以及一項國際專利并轉化。

代表性論文[近5年通訊作者和第一作者]

1. Deshan Ren, Wei Liu, Shuai Ding, Yan Li*(2022) The creation of human immune system mice and hydrodynamic injection to modulate human hematopoiesis in vivo, STAR protocols

2. Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen*, Yan Li*, Dan Ye*.(2022) Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity, Science Advances

3. Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li*, Lingyun Sun* (2021).Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics

4. Wei Liu; Hua Song; Xiaojing Li; Deshan Ren; Shuai Ding; Yan Li* (2021). Lipid Metabolism in Tumor Associated Myeloid-Derived Suppressor Cells, Lipid Metabolism in Tumor Immunity, Springer Book 

5. Shuai Ding, Siqi Li, Shujie Zhang and Yan Li * (2020) Genetic alterations and checkpoint expression: mechanisms and models for drug discovery. Regulation of Cancer Immune Checkpoints，Springer Book

6. Yan Li, Guillemette Masse Ranson, Zacarias Garcia, Timothee Bruel, Ayrin Kok-Harunova, Helene Strick-Marchand, Gregory Jouvion, Nicolas Serafini, Ai Ing Lim, Mathilde Dusseaux, Thierry Hieu, Frank Bourgade, Antoine Toubert, Daniela Finke, Oliver Schwartz, Phillippe Bousso, Hugo Mouquet and James P. Di Santo. (2018) A human immune system mouse model with robust lymph node development. Nature Methods 

7. Yan Li, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li and James P. Di Santo. (2017) Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nature Communications 

8. Ai Ing Lim, Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Cassrouge, Nicolas Serafini, Anne Puel, Laura Surace, Guillemette Masse-Ranson, Helene Strick-Marchand, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel and James P. Di Santo. (2017) Systemic human ILC precursors provide a substrate for tissue ILC differentiation, Cell

承擔科研項目[項目負責人]

獲獎情況

l Travel Award, 5^th International workshop on humanized mice, Switzerland

l Outstanding Young Investigator, 4^th International workshop on humanized mice, Korea