陳貴泉

姓名

陳貴泉

研究方向：

分子神經生物學

聯系方式

chenguiquan@nju.edu.cn

學術兼職：

中國細胞生物學會委員；

中國神經生物學會委員。

個人簡介

陳貴泉于2005年在英國愛丁堡大學獲得神經科學博士學位。陳貴泉實驗室長期從事神經系統相關疾病的機理研究。實驗室主要利用分子生物學、細胞神經生物學和遺傳學等手段研究小頭畸形及阿爾茨海默病(AD)的緻病機制。研究方向包括以下三個方面：（1）神經幹細胞和膠質前體細胞命運決定的分子機制；（2）神經退行死亡的分子機制；（3）AD藥物的篩選及作用機制的研究。

代表性論文[*，通訊作者]

1. XiaY, Zhang Y, Xu M, Zou X, Gao J*, Ji M*, ChenG*. Presenilinenhancer2 is crucial for the transition of apical progenitorsinto neurons but into not basal progenitors in the developinghippocampus. Development2022 (149):dev.200272.

2. TengX, Hu P, Chen Y, Zang Y, Ye X, Ou J, ChenG*,Shi YS*. Anovel Lgi1 mutation causes white matter abnormalities and impairsmotor coordination in mice. FASEBJ. 2022(36):e22212.

3. WangH, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, YangJ, Hu Y*, Chen G*.Akt regulates Sox10 expression to control oligodendrocytedifferentiation via phosphorylating FoxO1. J.Neurosci. 2021(41): 8163-8180.

4. HouJ, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q,Kirchhoff F, Hu Y*, ChenG*. Pen-2negatively regulates the differentiation of oligodendrocyteprecursor cells into astrocytes in the central nervous system. J.Neurosci. 2021(41):4976-4990.

5. WangH，LiuM，ZouG，WangL, Duan W，HeX, Ji M，ZouX, Hu Y*,Yang J*，ChenG*.Deletion of PDK1 inoligodendrocyte lineage cells causes white matter abnormality andmyelinationdefect in the central nervous system.Neurobiol. Dis.2021 (148): 105212.

6. BiH，ZhouC，ZhangY，CaiX，JiM，YangJ，ChenG*,Hu Y*.Neuron-specific deletion of presenilin enhancer2 causesprogressive astrogliosis and agerelated neurodegeneration in thecortex independent of the Notch signaling. CNSNeurosci. Ther.2021 (27):174-185.

7. WuJ, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B*, ChenG*, Liu H-K*, QianY* (2021) In vivo brain imaging of amyloid-aggregatesin Alzheimer's disease with a near-infrared fluorescent probe.ACS Sensors2021 (6):863-870.

8. WangQ, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, ChenG*, Gu X*.Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheralnerve injury. Exp.Neurol.2021 (343):113788.

9. ShaoC, Yuan J, Liu Y, Wang X, Gu J, ChenG, Zhang B, Liu H,Zhao J*,Zhu H* andQian Y*.Epilepticbrain fluorescent imaging reveals apigenin can relieve themyeloperoxidase-mediated oxidative stress and inhibitferroptosis.PNAS2020 (117):10155-10164.

10. HuangC, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, ChenG*,Yin Z*and Hu Y*.Loss of PP2A disrupts the retention of radial glial progenitorsin the telencephalic niche to impair the generation of late-bornneurons during cortical development (Coverstory). Cereb.Cortex2020(30):4183-4196.

11. Ma X, Wang Y, Hua J, Xu C,Yang T, Yuan J, ChenG*,Guo Z*and Wang X*.Aβ-sheet-targeted theranostic agent for diagnosing andpreventing aggregation of pathogenic peptides in Alzheimer’sdisease (Coverstory). Sci.China Chem.2020 (63):73-82.

12. ChengS, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, LuJ* and ChenG*.Conditional inactivation ofPen-2 in thedeveloping neocortex leads to rapid switch of apical progenitorsto basal progenitors. J.Neurosci. 2019(39):2195-2207.

承擔科研項目[項目負責人]

1. 國家自然科學基金重大研究計劃培育項目一項；

2. 國家自然科學基金面上項目一項。

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