陳迪

姓名

陳迪

研究方向：

衰老生物學

聯系方式

chendi@nju.edu.cn

學術兼職：

中國老年學學會衰老與抗衰老科學委員會委員

中國動物學會發育生物學專業委員會委員

Frontiers in Genetics期刊編委

Molecules and Cells期刊編委

Frontiers in Aging期刊編委

個人簡介

2004年畢業于美國密蘇裡大學哥倫比亞分校，獲哲學博士學位。2005-2012年間在美國巴克衰老研究所從事博士後和研究員工作。2013年至今在南京大學任副教授。長期從事以秀麗隐杆線蟲（C. elegans）為模式的發育和衰老生物學研究。主要研究方向包括:（1）Insulin/IGF-1和TOR信号通路組織特異性調控衰老的系統生物學研究；（2）飲食限制（dietary restriction）延緩衰老的分子機理；（3）RNA代謝調控衰老及其相關疾病的分子機制。

代表性論文[近5年通訊作者和第一作者]

1. Di Wu^#, Waijiao Cai^#, Xuan Zhang, Jianfeng Lan, Lina Zou, Samuel J. Chen, Zixing Wu, Di Chen*, Inhibition of PAR-1 Delays Aging via Activating AMPK in C. elegans. Aging, 2020, 12(24): 25700-25717. (^#, co-first authors)

2. Jianfeng Lan^#, Jarod A. Rollins^#, Xiao Zang^#, Di Wu^#, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi*, Aric N. Rogers*, Di Chen*, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019, 28(4): 1050-1062.e6. (^#, co-first authors)

3. Lina Zou, Di Wu, Xiao Zang, Zi Wang, Zixing Wu, Di Chen*, Construction of a Germline-specific RNAi tool in C. elegans. Scientific Reports, 2019, 9(1): 2354.

4. Lei Gao, Rujun Zhang, Jianfeng Lan, Ruonan Ning, Di Wu, Di Chen*, Weimin Zhao*, -Dihydroagarofuran-type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-extending Effects on the Nematode Caenorhabditis elegans. Journal of Natural Products, 2016, 79(12): 3039-3046.

5. Lei Hou^#, Dan Wang^#, Di Chen^#, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, William B. Mair, Jing-Dong J. Han, A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 23(3): 529-540. (^#, co-first authors)

6. Jianfeng Lan, Xuan Zhang, Di Chen*, Molecular Mechanisms of Dietary Restriction in Aging - Insights from Caenorhabditis elegans Research, Science China Life Sciences, 2015, 58(4): 352-358.

7. Di Chen*, Jiuli Zhang, Justin Minnerly, Tiffany Kaul, Donald L. Riddle, Kailiang Jia*, daf-31 Encodes the Catalytic Subunit of N alpha-Acetyl Transferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan, PLoS Genetics, 2014, 10(10): e1004699.

8. Di Chen*, Patrick Wai-Lun Li, Benjamin A. Goldstein, Waijiao Cai, Emma Lynn Thomas, Fen Chen, Alan E. Hubbard, Simon Melov, Pankaj Kapahi*, Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans, Cell Reports, 2013, 5(6): 1600-1610.

承擔科研項目[項目負責人]

在研項目：

1. 2022-2025，細胞色素C調控秀麗隐杆線蟲衰老的分子機制研究，國家自然科學基金委面上項目，32171156，58萬元。

2. 2021-2026，果蠅和線蟲發育代謝資源庫的系統構建與分析，科技部國家重點研發計劃，子課題，2021YFA0805802，120.86萬元。

3. 2020-2023，秀麗線蟲神經系統通過mRNA可變剪接調控衰老的分子機制研究，國家自然科學基金委面上項目，31971092，58萬元。

獲獎情況