窦環博士
高級工程師
電話:025-89681086郵箱:douhuan@nju.edu.cn 地址:南京大學鼓樓校區東南樓230室研究方向:

固有免疫與炎症性疾病

  • 個人簡介
  • 學術兼職
  • 代表性論文
  • 承擔科研項目
  • 獲獎情況

博士,高級工程師,碩士研究生導師

江蘇省“六大人才高峰”高層次人才

教育經曆

1997-2001年,中國藥科大學藥學院,本科生

2002-2005年,南京大學生命科學學院,碩士研究生

2012-2013年,美國Purdue University, College of Pharmacy,訪問學者

2009-2013年,南京大學生命科學學院,博士研究生

工作經曆:

2006-至今,南京大學,高級工程師,碩士生導師

教學科研情況:

主要從事免疫學的實驗教學及研究工作,建立“醫學免疫學研究導向型”實驗教學模式,指導大學生創新訓練項目及研究生高水平研究技能培訓,主持2項南京大學本科生教學改革項目,參與江蘇省本科生教改重點項目等,獲軟件著作權1項。長期緻力于固有免疫調控炎症性疾病的分子免疫機制及臨床轉化研究,主持國家自然科學基金、江蘇省自然科學基金等科研課題13項,參與國家自然科學基金重大研究計劃、科技部“重大新藥創制”科技專項基金、教育部博士點專項基金、江蘇省科技廳社會發展(醫藥)重點項目等研究項目。授權中國發明專利2項,發表國内外期刊論文80餘篇,為Arthritis RheumatolFront ImmunolPhenomicsClin Transl Discov等學術期刊審稿人。

中國免疫學會江蘇省青工委委員

江蘇省免疫學會轉化醫學專業委員會委員

江蘇省免疫學會免疫與代謝專業委員會委員

近5年,通訊/共同通訊作者

1. Qiao X, Lu L, Zhou K, Tan L, Liu X, Ni J, Hou Y*, Liang J*, Dou H*. The correlation between proteoglycan 2 and neuropsychiatric systemic lupus erythematosus. Clin Immunol. 2022, 239:109042.

2. Ni J, Zhu H, Lu L, Zhao Z, Jiang J, You X, Wang Y, Ma Y, Yang Z, Hou Y*, Dou H*. Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms. Mol Med, 2022. 28(1):65.

3. Lu L, Liu X, Fu J, Liang J*, Hou Y*, Dou H*. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Sci Rep. 2022, 12(1):7047.

4. Wang S, Tan Q*, Hou Y *, Dou H*. Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes. Front. Pharmacol. 2021, 12:798320.

5. Lu L, Wang H, Liu X, Tan L, Qiao X, Ni J, Sun Y*, Liang J*, Hou Y*, Dou H*. Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway. J Neuroinflammation. 2021 Oct 13;18(1):229.

6. Li D, Lu L, Kong W, Xia X, Pan Y, Li J, Wang J, Wang T*, Liang J*, Dou H*, Hou Y*. C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1+M-MDSCs in relieving lupus-like symptoms. Cell Death Dis, 2021 Sep 3;12(9):829.

7. Shi G, Li D, Zhang D, Xu Y, Pan Y, Lu L, Li J, Xia X, Dou H*, Hou Y*. IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development. Cell Death Discov, 2021, 7(1):179.

8. Sun Z, Qu J, Xia X, Pan Y, Liu X, Liang H*, Dou H*, Hou Y*. 17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis. Int J Biol Sci, 2021, 17(2):460-474.

9. Lu L, Zhu H, Wang H, Liang H, Hou Y*, Dou H*. H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis. Front Med, 2021, 15(2):313-329.

10. Fu J, Lu L, Wang H, Hou Y*, Dou H*. Hirsutella sinensis mycelium regulates autophagy of alveolar macrophages via TLR4/NF-κB signaling pathway. Int J Med Sci, 2021, 18(8):1810-1823.

11. Qiao X, Wang H, Lu L, Chen J, Cheng Q, Guo M, Hou Y*,Dou H*. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. J Neuroimmunol, 2021, 357:577620.

12. Lu L, Kong W, Zhou K, Chen J, Hou Y*,Dou H*, Liang J*. Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus. BMC Rheumatol. 2021, 5(1):18.

13. Tan L, Liu X, Dou H*, Hou Y*. Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment specific factors involved in the regulation of MSC plasticity. Genes Dis, 2020, 9(2):296-309.

14. Li D, Pan Y, Xia X, Liang J, Liu F*, Dou H*, Hou Y*. Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells. Eur J Pharmacol, 2020. 884:173421.

15. Lu L, Tong Y, Wang W, Hou Y*, Dou H*, Liu Z*. Characterization and Significance of Monocytes in Acute Stanford Type B Aortic Dissection. J Immunol Res, 2020:9670360.

16. Sun Z, Pan Y, Qu J, Xu Y, Dou H*, Hou Y*. 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Front Immunol, 2020, 11:1591.

17. Zhu H, Fu J, Chen S, Li X, Liang H*, Hou Y*, Dou H*. FC-99 reduces macrophage tenascin-C expression by upregulating miRNA-494 in arthritis. Int Immunopharmacol, 2020, 79:106105.

18. Gong W, Zhu H, Lu L, Hou Y, Dou H*. A Benzenediamine Analog FC-99 Drives M2 Macrophage Polarization and Alleviates Lipopolysaccharide- (LPS-) Induced Liver Injury. Mediators Inflamm, 2019, 2019:7823069.

19. Xu Y, Li Y, Liu X, Pan Y, Sun Z, Xue Y, Wang T, Dou H*, Hou Y*. SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1/HES1-mediated autophagy. Int J Nanomedicine, 2019, 14:6779-6797.

20. Li D, Qi J, Wang J, Pan Y, Li J, Xia X, Dou H*, Hou Y*. Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway. Free Radic Biol Med, 2019, 143:260-274.

21. Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H*, Hou Y*. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res Ther, 2019, 21(1):105.

22. Shi G, Li D, Ren J, Li X, Wang T*, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates dextran sodium sulfate-induced colitis by promotion of MDSCs on Treg cell expansion. J Cell Physiol. J Cell Physiol, 2019, 234(2):1618-1629.

23. Shi G, Li D, Li X, Ren J, Xu J, Ding L, Dou H*, Hou Y*. mTOR inhibitor INK128 attenuates systemic lupus erythematosus by regulating inflammation induced CD11b+Gr1+ cells. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(1):1-13.

24. Xu Y, Xue Y, Liu X, Li Y, Liang H*, Dou H*, Hou Y*. Ferumoxytol Attenuates the Function of MDSCs to Ameliorate LPS-Induced Immunosuppression in Sepsis. Nanoscale Res Lett. 2019, 14(1):379.

25. Zhang D, Xu J, Ren J, Ding L, Shi G, Li Dan, Dou H*, Hou Y*. MDSCs Induce Podocyte Injury through Increasing Reactive Oxygen Species in Lupus Nephritis. Front Immunol. 2018, 9:1443.

26. Li X, Zhang X, Pan Y, Shi G, Ren J, Fan H, Dou H*, Hou Y*. mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus. Acta Biochim Biophys Sin (Shanghai), 2018, 50(9):888-896.


1.國家自然科學基金面上項目32070883:狼瘡中FoxO1調控獨特表型LOX-1+M-MDSC數量及其功能變化的機制研究,2021/01-2024/12。主持

2.國家自然科學基金面上項目(32171358):3D打印曲面梯度支架負載MDSCsMSCs構建血管化半月闆的研究,2022/01-2025/12。合作參與

3.白求恩•普愛醫學研究基金(PAYJ-008):基于高通量蛋白芯片的狼瘡性腦病新型生物标志物研究,2022/06-2024/06。合作參與

4.江蘇省重點研發計劃(社會發展)臨床前沿項目(BE2019617):Toll樣受體激動劑在卵巢癌分子靶向精準診治中的技術開發與應用研究,2019/07-2022/06。合作參與

5.橫向課題(20190167):中藥飲片鹿血晶藥效及作用機制藥效評價的合作,2019/06-2022/06。主持

6.江蘇省六大人才高峰高層次人才項目(YY-021):sTREM-1介導小膠質細胞M1極化在促進狼瘡腦病進展中的分子機制研究。主持

7.國家自然科學基金青年項目(81402940):FC-99通過miRlet-7調控巨噬細胞IL-6緩解RA的作用機制研究。主持

8.江蘇省自然科學基金青年項目(BK20140615):FC-99通過miR let-7調控巨噬細胞産生IL-6的分子機制及其在抗類風濕性關節炎中的作用。主持

9.江蘇省教育廳研究生培養創新工程基金(CXZZ11_0036):新型靶向金屬碳硼烷分子探針的抗腫瘤作用及機理初探。主持

10.中央高校原創與交叉研究培養基金(021414380342):髓系抑制性細胞在3D打印精準構建小口徑血管術後再狹窄中的作用研究。主持

11.橫向課題(0214151037):雲克影響RA骨侵蝕的細胞信号轉導途徑及機制。主持


2015年,獲伟德官网手机版“優秀帶教與實驗教學技術人員”稱号;

2018年,獲全國虛拟教學網絡設計大賽三等獎;

2018年,獲江蘇省第十五批“六大人才高峰”高層次人才稱号;

2019年,獲南京大學本科實踐教學優秀指導教師稱号;

2022年,獲南京大學育教融合獎。


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