作者:2021-10-25浏覽次數:18490

韓曉冬

博士研究生導師簡介

姓名

韓曉冬

研究方向

1生殖與發育

2環境污染與疾病發生

3幹細胞與組織再生

聯系方式

電話025-83686497

Email: hanxd@nju.edu.cn

學術兼職:

教育部高等學校基礎醫學類專業教學指導委員會委員

江蘇省解剖學會理事長

《中華男科學雜志》 編委

個人簡介

組織胚胎學教授,博士生導師。1984年畢業于南京大學生物系,獲學士學位;1987年于南京大學生物系獲碩士學位;2004年于南京大學生命科學院獲博士學位。2001年,作為高級訪問學者赴美國哈佛大學伟德官网手机版Beth Israel Deaconess Medical Center開展合作研究。長期從事生殖與發育、環境污染與疾病發生、幹細胞與組織再生研究,主持并參與國家自然科學基金、國家973計劃、教育部博士點基金、江蘇省自然科學基金等研究項目,在國内外學術刊物共發表論文210餘篇。參編《組織胚胎學》、《生殖病理學》教材。講的組織學與胚胎學”入選南京大學百門優質課程,被認定為省級一流本科課程

承擔科研項目[項目負責人]

  1. 國家自然科學基金項目(31870492):微囊藻毒素長期低劑量暴露引起小鼠學習記憶能力減退的分子機制探讨

  2. 國家自然科學基金項目(81570059):Hedgehog-Wnt信号通路參與特發性肺纖維化發病的分子機制探讨及疾病幹預的基礎研究

  3. 國家自然科學基金項目(31370524):微囊藻毒素下調雄性大鼠雄激素(睾酮)合成和分泌的機制研究

  4. 國家自然科學基金項目(30970530):微囊藻毒素低劑量長時間暴露對雄性大鼠生殖系統的影響及其機制研究

  5. 國家自然科學基金項目(81170054):調控Wnt信号通路對特發性肺纖維化發生發展影響的研究

  6. 國家自然科學基金項目(20577019):環境内分泌幹擾物烷基酚生殖毒性風險評價标準的探索

  7. 高等學校博士學科點專項科研基金20130091110050):微囊藻毒素通過下丘腦-垂體-睾丸軸下調雄性激素合成及分泌的機制研究

  8. 江蘇省自然科學基金(BE2021707):特發性肺纖維化預警标志物鑒定及靶向幹預肺巨噬細胞OPN治療肺纖維化關鍵技術研究

  9. 江蘇省自然科學基金(BK2011570):調控WNT信号通路對特發性纖維化發生發展影響的研究

  10. 江蘇省自然科學基金(BK20151398):Hedgehog-Wnt信号通路參與特發性肺纖維化發病的分子機制探讨及疾病幹預的基礎研究

  11. 國家重點基礎研究發展計劃973”計劃課題子項目2010CB945103):卵巢早衰的分子機制及其早期預測、診斷生物标記的研究

  12. 國家重點基礎研究發展計劃973”計劃課題子項目(2007CB815603):微生物群落分解礦物的機理及其對生态環境的影響

獲獎情況

2021年獲南京大學“趙世良講座教授”稱号。

2018年獲南京大學本科實踐教學優秀指導教師稱号。

2017年獲寶鋼優秀教師獎稱号。

2010年獲南京大學我最喜愛的教師稱号。

發表論文

  1. Pan Chun, Yan Minghao, Jin Haibo, Guo Hongqian*, 韓曉冬* Chronic exposure to MC-LR increases the risks of microcytic anemia: Evidence from human and mice. Environ Pollut. 2021 Nov 1; 288:117966. doi: 10.1016/j.envpol.2021.117966.

  2. Minghao Yan, Shen Gu, Chun Pan, Yabing Chen,韓曉冬* MC-LR-induced interaction between M2 macrophage and biliary epithelial cell promotes biliary epithelial cell proliferation and migration through regulating STAT3. Cell Biol Toxicol Published:21 January 2021 https://doi.org/10.1007/s10565-020-09575-9  

  3. Ma Yuhan, Wang Jing, Xu Dihui, Chen Yabing*, 韓曉冬*. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. Science of The Total Environment, Available online 29 June 2021, 148732.

  4. Ji Jie, Hou Jiwei, Xia Yunhui, Xiang Zou, 韓曉冬*. NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis. Biochim Biophys Acta Mol Basis Dis. 20211867:166077.

  5. Chen Yabing, Pan Chun, Wang Xiaotong, Xu Dihui, Ma Yuhan, Hu Jianhang, Chen Peilin, Xiang Zou, Rao Qiu*, 韓曉冬*. Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells. Theranostics 2021; 11(16): 7640-7657.

  6. Xu Dihui, Ma Yuhan, 韓曉冬*, Chen Yabing*. Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells. Journal of Hazard Materials. 2021, 417: 126092.

  7. Hou Jiwei, Ji Qijian, Ji Jie, Ju Shenghong, Xu Chun, Yong Xueqing, Xu Xiaoxuan, Muddassir Mohd, Chen Xiang, Xie Jinbing*, 韓曉冬*.Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast -targeting polymeric micelles for idiopathic pulmonary fibrosis therapy. Theranostics. 2021 Jan 9; 11(7):3244-3261. Theranostics. 202111: 3244-3261.

  8. Jin Haibo, Ma Tan, Sha Xiaoxuan, Liu Zhengyu, Zhou Yuan, Meng Xiannan, Chen Yabing, 韓曉冬*, Die Jie*. Polystyrene microplastics induced male reproductive toxicity in mice. Journal of Hazardous Materials, 2021401: 123430.

  9. Chen Yabing, Wang Jing, Xu Dihui, Xiang Zou, Ding Jie, Yang Xiaoyu, Li Dongmei*, 韓曉冬*. m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy. 2021,17(2):457-475.

  10. Xu Dihui, Wang Jing, Ma Yuhan, Ding Jie, 韓曉冬, Chen Yabing. Microcystin-leucine-arginine induces apical ectoplasmic specialization disassembly. Chemosphere. 2021264:128440.

  11. Pan Chun, Zhang Ling, Meng Xiannan, Qin Haixiang, Xiang Zou, Gong Wenyue, Luo Wenxin, Li Dongmei, 韓曉冬*. Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells. Chemosphere. 2021263: 128295.

  12. Meng Xiannan, Zhang Ling, Hou Jiwei, Ma Tan, Pan Chun, Zhou Yuan, Han Ruitong, Ding Yuanzhen, Peng Haoran, Zou Xiang, Li Dongmei*, 韓曉冬*. The mechanisms in the altered ontogenetic development and lung-related pathology in microcystin-leucine arginine (MC-LR)- paternal-exposed offspring mice. Science of the Total Environment. 2020, 736: 139678.

  13. Zhang Changliang, Wang Jing, Zhu Jinling, Chen Yabing, 韓曉冬*. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Science of The Total Environment. 2020,703:134702.

  14. Wang Jing, Zhang Changliang, Zhu Jinling, Ding Jie, Chen Yabing , 韓曉冬*. Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. Science of the Total Environment, 2019, 689: 662–678.

  15. Wang Jing, Chen Yabing, Zhang Changliang, Xiang Zou, Ding Jie*, 韓曉冬*. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials, 2019, 373: 504–518.

  16. Meng Xiannan, Peng Haoran, Ding Yuanzhen, Zhang Ling, Yang Jingping, 韓曉冬*. A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity. Science of the Total Environment, 2019, 667: 563–577.

  17. Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and 韓曉冬*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling. 2018 ,16:89, doi: 10.1186/s12964-018-0300-8.

  18. Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei, and 韓曉冬*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia. Environmental Pollution. 2018,242: 1535-1545.

  19. Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and 韓曉冬*. Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice. Science of the Total Environment. 2018, 643:496–506.

  20. Chen Xiang, Shi Chaowen, Cao Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and 韓曉冬*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death & Disease. 2018,9:639.

  21. Chen Yabing, Wang Jing, 韓曉冬*, et al. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, 2018, 75(6):1117-1132.

  22. Chaowen Shi, Xiang Chen, Zhaorui Sun, Zou xiang, Weiping Qian,韓曉冬*. Intracellular SERS probes based on -conjugated AuNSs for distinguishing between the differentiation of lung resident mesenchymal stem cells. Biomaterials. 2015, 58:10-25.

  23. Yuan Zhou, Zou Xiang, Dongmei Li*, 韓曉冬*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014,48:6383-6390.



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