作者:2018-11-22浏覽次數:23997

史冬泉

博士研究生導師簡介

姓名

史冬泉

研究方向:

膝關節(軟骨、半月闆、韌帶、肌腱)發育與再生

聯系方式

13951003149shidongquan@nju.edu.cn

學術兼職:

中國骨科醫師協會骨關節炎工作組       秘書兼委員

中國骨科醫師協會再生醫學工作組       委員

中國骨科醫師協會青年委員會           委員

中華醫學會組織修複與再生委員會       青年委員

吳階平醫學基金會青年骨科醫師聯盟     副主任委員

 Annals of Joint                      執行主編

 Annals of Translational Medicine     副主編

 BMC Surgery                          副主編

《中華關節外科雜志》                 編委

《實用老年醫學》                     編委

個人簡介

南京大學博士生導師、國家優秀青年基金獲得者、全國青聯委員(醫藥衛生界别副主任委員)、江蘇省青聯醫藥衛生界别 主任委員;江蘇省五四青年獎章獲得者、江蘇省醫學重點人才;伟德官网手机版附屬鼓樓醫院 主任醫師。

臨床方向:成人重建外科(關節置換、關節重建成形)和運動醫學(關節鏡及其康複)。擅長運動醫學及關節外科疾病的診治,同時掌握關節鏡下治療交叉韌帶損傷、半月闆成形等微創手術,以及初次髋膝關節置換。每年完成關節置換約400例,運動醫學相關手術200例。并開展了多項臨床随機對照試驗。

科研業績:根據骨性關節炎遺傳學特質和軟骨損傷修複的基礎應用研究方面進行了一系列的研究創新,迄今共發表英文論文110篇,包括 ACS NanoAngew Chem Int Ed EnglScience AdvancesNano researchNat MedNat Genet等。發表SCI論文共被引用1890次,每年平均被引135.0次,H指數23。主持NSFC優秀青年項目1,專項項目1項,面青項目3項,科技部國家重點研發計劃子課題1項。獲得 2014年教育部自然科學二等獎;2015年中華醫學會骨科分會青年基礎研究獎一等獎;2018年江蘇省科技進步一等獎,2019年江蘇省醫學科技獎二等獎。




代表性論文[5年通訊作者和第一作者]

 1. Mimi Wan #*; Qi Wang# ; Rongliang Wang; Rui Wu; Yueqi Yu; Ting Li; Leyi Fang; Xingwen Wang; Yinghua Zhang; Zhuoyue Miao; Bo Zhao; Fenghe Wang; Chun Mao* ; Qing Jiang; Xingquan Xu; Dongquan Shi*;Platelet-derived Porous Nanomotor for Thrombus Therapy. Science Advances;2020; 6(22): eaaz9014.


 2. Meng Wang #, Wenqiang Yan#, Meilin Chu, Ting Li, Zhiyong Liu, Yueqi Yu, Yangyang Huang, Tianyu Zhu, Mimi Wan*, Chun Mao*, Dongquan Shi*. Erythrocyte Membrane-Wrapped Magnetic Nanotherapeutic Agents for Reduction and Removal of Blood Cr(VI).ACS Appl Mater Interfaces. 2020;12(25):28014-28023.


 3. Xingquan Xu#; Rongliang Wang# ; Rui Wu; Wenjin Yan; Tianshu Shi; Qing Jiang * ; Dongquan Shi* ;Trehalose reduces bone loss of experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation. FASEB J. 2020;34(6):8402-8415.


 4. Wenqiang Yan#, Xingquan Xu#, Qian Xu, Ziying Sun, Zhongyang Lv, Rui Wu, Wenjin Yan, Qing Jiang*, and Dongquan Shi*;An injectable hydrogel scaffold with kartogenin-encapsulated nanoparticles for porcine cartilage regeneration – a 12-month follow-up study.The American Journal of Sports Medicine.已接收


 5. Wenqiang Yan#, Xingquan Xu#, Qian Xu, Ziying Sun, Zhongyang Lv, Rui Wu, Wenjin Yan, Qing Jiang*, and Dongquan Shi*; Chondral defects cause kissing lesions in a porcine model.Cartilage.已接收


 6. Mimi Wan; Tingting Xu; Bo Chi; Meng Wang; Yangyang Huang; Qi Wang; Ting Li; Wenqiang Yan; Huan Chen; Ping Xu; Chun Mao* ; Bo Zhao; Jian Shen * ; Hong Xu; Dongquan Shi * ;A Safe and Efficient Strategy for the Rapid Elimination of Blood Lead In Vivo Based on a Capture-Fix-Separate Mechanism, Angew Chem Int Ed Engl., 2019, 58(31): 10582-10586.


 7. Wenxu Sun#; Heting Jiang #; Xin Wu# ; Zhengyu Xu; Chen Yao; Juan Wang;  Meng Qin; Qing Jiang; Wei Wang * ; Dongquan Shi*; Yi Cao*; Strong , dual-crosslinked hydrogels for ultrasound-triggered drug delivery. Nano Reaearch, 2019, 12: 115-119.


 8. Dongquan Shi; Xingquan Xu; Yanqi Ye; Kai Song; Yixiang Cheng; Jin Di; Quanyin Hu; Jianxin Li; Huangxian Ju; Qing Jiang*; Zhen Gu*; Photo-Cross-Linked, Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration. ACS Nano, 2016 ,10(1): 1292-1299.


 9. Wenqiang Yan#; Xingquan Xu#; Qian Xu; Ziying Sun; Qing Jiang*; Dongquan Shi*; Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up.Regen Biomater, 2020, 7(1):77-90.


 10. Wenqiang Yan#; Xingquan Xu#; Qian Xu; Wenjin Yan; Ziying Sun; Qing Jiang*; Dongquan Shi*; Femoral and tibial torsion measurements based on EOS imaging compared to 3D CT reconstruction measurements. Ann Transl Med.,2019 ,7(18) :460.


 11. Rongliang Wang#; Xingquan Xu#; Yixuan Li; Jiawei Li; Chen Yao; Rui Wu; Qing Jiang*; Dongquan Shi*; A C-Met chemical inhibitor promotes fracture healing through interacting with osteogenic differentiation via the mTORC1 pathway. Experimental Cell Research, 2019, 381(1): 50-56.  


 12. Jiawei Li# ; Guojun Chen# ; Xingquan Xu; Peter Abdou; Qing Jiang; Dongquan Shi* ; Zhen Gu*; Advances of injectable hydrogel-based scaffolds for cartilage regeneration. Regen Biomater. 2019, 6(3): 129-140.


 13. Xingquan Xu#; Rongliang Wang#; Ziying Sun; Rui Wu; Wenjin Yan; Qing Jiang *; Dongquan Shi*. Trehalose enhances bone fracture healing in a rat sleep deprivation model. Ann Transl Med., 2019, 7(14): 297.


 14. Wenqiang Yan#; Xingquan Xu#; Qian Xu; Ziying Sun; Dongyang Chen; Zhihong Xu; Qing Jiang *; Dongquan Shi*; In vivo gait kinematics of the knee after anatomical and non-anatomical single-bundle anterior cruciate ligament reconstruction-a prospective study. Ann Transl Med, 2019, 7(24) : 799.


 15. Tao Jiang#; Yao Yao#; Xingquan Xu; Kai Song; Pin Pan; Dongyang Chen; Zhihong Xu; Jin Dai; Jianghui Qin; Dongquan Shi*; Qing Jiang*; Prevalence and Risk Factors of Preoperative Deep Vein Thrombosis in Patients with End-Stage Knee Osteoarthritis. Annals of Vascular Surgery ,2019 , 64 : 175-180.


 16. Chen Yao#; Zhe Zhang#; Yao Yao; Xingquan Xu; Qing Jiang *; Dongquan Shi*; Predictive value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for acute deep vein thrombosis after total joint arthroplasty: a retrospective study. J Orthop Surg Res, 2018, 13(1) : 40.


 17. Xingquan Xu; Chen Yao; Rui Wu; Wenjin Yan; Yao Yao; Kai Song; Qing Jiang*; Dongquan Shi*; Prevalence of patellofemoral pain and knee pain in the general population of Chinese young adults: a community-based questionnaire survey. BMC Musculoskelet Disord ,2018, 19(1): 165.


 18. Chen Yao#; Bowen Zhu#; Yubao Liu; Xingquan Xu; Xianfeng Yang; Zhihong Xu; Jin Dai; Dongyang Chen; Huajian Teng; Dongquan Shi*; Qing Jiang*; Association of MMP3 COL5A1 and COL1A1 gene polymorphisms with ACL geometric size in Chinese population. International journal of clinical and experimental pathology, 2017, 10(2) : 1991-1997.


 19. Xingquan Xu; Dongquan Shi*; Yubao Liu; Yao Yao; Jin Dai; Zhihong Xu; Dongyang Chen; Huajian Teng; Qing Jiang* ;In vivo repair of full-thickness cartilage defect with human iPSC-derived mesenchymal progenitor cells in a rabbit model. Exp Ther Med,2017,14(1) : 239-245.


 20. Chen Yao; Xingquan Xu; Sheng Zhou; Xiaoxiao Song; Dongquan Shi*; Qing Jiang *; Total knee arthroplasty conversion after a failed lateral closing wedge high tibial osteotomy with knee hyperextension and secondary ankle degeneration A case report. Medicine (Baltimore), 2017, 96(29): e7473.


 21. Xingquan Xu; Dongquan Shi*; Wenjin Yan; Yao Yao; Jin Dai; Yeshuai Shen; Zhihong Xu; Dongyang Chen; Qing Jiang *; Lack of association of a single nucleotide polymorphism in SMOC1 with developmental dysplasia of the hip: a , case-control study. International journal of clinical and experimental pathology,2016, 9(10): 10734-10739.  


 22. Xingquan Xu; Dongquan Shi*; Yubao Liu; Yeshuai Shen; Zhihong Xu; Jin Dai; Dongyang Chen; Huajian Teng; Qing Jiang *; Synovium-derived mesenchymal stem cell sheet enhance autologous osteochondral transplantation in a rabbit model. International Journal of Clinical and Experimental Medicine, 2016, 9(6):10322-10332.


 23. Dongquan Shi; Xingquan Xu; Anyun Guo; Jin Dai; Zhihong Xu; Dongyang Chen; Qing Jiang *; Bone Cement Solidifiliation Influence the Limb Alignment and Gap Balance during TKA. Biomed Res Int, 2015, 2015: 109402.


 24. Xingquan Xu; Dongquan Shi*; Yeshuai Shen; Zhihong Xu; Jin Dai; Dongyang Chen; Huajian Teng; Qing Jiang *; Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. Arthritis Res Ther ,2015 ,17(1) : 20.


25. Dongquan Shi; Jin Dai; Zhihong Xu; Dongyang Chen; Qing Jiang*, Update on basic and clinical aspects of osteoarthritis. Ann Transl Med, 2015, 3(10): 142.

承擔科研項目[項目負責人]

1. 國家自然科學基金委員會,專項項目,81941009,代謝相關性小型豬骨質疏松模型的 建立,2020-012022-12,在研,主持

2. 江蘇省人事廳,六大人才高峰-高層次人才A類,WSW-079,軟骨修複,2019-10202210,在研,主持

3. 國家科學技術部,國家重點研發計劃,2018YFC1105900,關節軟骨再生性植入材料研 發及功能評價,2018-072020-12,在研,主持

4. 國家自然科學基金委員會,面上項目,81772335,緩釋小分子藥物BIO透明質酸凝膠修 複軟骨缺損的研究,2018-012021-12,在研,主持

5. 國家自然科學基金委員會,優秀青年科學基金項目,81622033,運動醫學,2017-012019-12,已結題,主持

6. 江蘇省人事廳,六大人才高峰-高層次人才C類,WSW-061,緩釋小分子有機化合物BIO 的多肽水凝膠修複軟骨缺損,2016-102019-10,已結題,主持

7. 國家自然科學基金委員會,面上項目,81572129,紫外聚合緩釋Kartogenin PLGA納米 顆粒/水凝膠複合支架修複軟骨缺損,2016-012019-12,已結題,主持

8. 江蘇省衛生健康委員會,科教強衛工程江醫學重點人才,緩釋小分子藥物Kartogenin 治療軟骨缺損性疾病,2016-012020-12,在研,主持

9. 江蘇省科技廳,重點研發計劃社會發展項目,BE2016609,緩釋小分子藥物Kortogenin 治療軟骨損傷性疾病,2016-012019-12,已結題,主持

10. 南京市衛生局,傑出青年基金項目,JQX13009,關節腔注射Kartogenin修複軟骨缺損 ,2013-012016-12,已結題,主持

11. 江蘇省人事廳,六大人才高峰-高層次人才D類,WSW-006,軟骨再生醫學研究,2012-1 02015-10,已結題,主持

12. 國家自然科學基金委員會,青年科學基金項目,81101338Aspori基因在發育性髋關 節發育不良發病作用,2012-012014-12,已結題,主持

13. 南京市衛生局,青年科技人才啟動項目,第三層次,2011-012015-12,已結 題,主持

14. 中央高校專項基金,南大中央高校苗圃項目,Aspori基因在發育性髋關節發育不良發病作用,2008-012012-12,已結題,主持



獲獎情況

1. 關節軟骨損傷修複研究 江蘇醫學科技獎二等獎 江蘇省醫學會 2019

2. 骨關節炎的基礎與臨床研究 江蘇省科技進步獎一等獎 江蘇省人民政府 2018

3.COA骨科基礎青年研究一等獎 中華醫學會 2016

4.骨關節炎的基礎與臨床研究 自然科學獎二等獎 中華人民共和國教育部 2014

5.骨性關節炎的基礎與臨床研究 南京市科技進步獎二等獎 南京市人民政府 2013

6.骨性關節炎的基礎與臨床研究 江蘇醫學科技獎等獎江蘇省醫學會 2010

7.骨關節疾患易感基因的多态性研究 江蘇省科技進步獎等獎江蘇省人民政府 2009

8.骨關節疾患易感基因的多态性研究 南京市科技進步獎一等獎 南京市人民政府 2009

9.2016年第十一屆“江蘇青年五四獎章”獲得者;

10.2016年“南京市青年五四獎章”獲得者

11. 2010 OARSI Travel Award

12. 2014 OARSI Travel Award




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