研究生導師簡介
姓名 | 朱敏生 | 研究方向： | 腸道微生物與平滑肌生理學 |
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聯系方式 | zhums@nju.edu.cn | ||||
學術兼職： 中國細胞生物學會理事 江蘇省發育生物學會監事 | |||||
個人簡介 | |||||
1995年畢業于中國科學院上海生物化學研究所，獲理學博士學位。1999-2001年間在美國德州大學西南醫學中心生理系從事博士後研究，2004年至今在南京大學任教授。長期從事小鼠遺傳學、平滑肌收縮生理學與疾病研究。在系統生物學水平，研究闡明了平滑肌收縮鈣機制、鈣敏機制的分子基礎；從平滑肌角度，系統闡明了胃腸動力調節機制、肛門括約肌的自發收縮機制、哮喘高反應性形成機制、肥胖性高血壓形成機制等。在此基礎上，開展平滑肌相關疾病（如胃腸病、哮喘、血管病、神經退行性病變等）的發病機制研究和轉化研究。研究成果分别發表在 Gastroenterology（2008、2013）、J Clin Invest.（2022）、PNAS(2015、2022)、J. Biol. Chem. (2010、2010、2014、2014、2019、2021)、J Physiol (2014)、 Am J. Physiol (2011)、Nature Med (2012)、 AJRCCM (2013)、Nature Communications(2016)、Genome Biol (2016)、J Allegy Clin Immunol (2018)、CMGH（2019）等權威雜志上。2016年獲國家科技進步二等獎1項（第2）。 | |||||
代表性論文[近5年通訊作者和第一作者] | |||||
1. Zhou YW, Sun J, Wang Y, Chen CP, Tao T, Ma M, Chen X, Zhang XN, Yang LY, Zhang ZL, Li YQ, Jiang ZH, Qiu TT, Wang H, Pan Y, Zhang J, Chen HQ, Wang P, Zhu MS. Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling. PNAS. 2022 Jun 28;119(26):e2121513119. doi: 10.1073/pnas.2121513119.
2. Chen X, Qiu TT, Wang Y, Xu LY, Sun J, Jiang ZH, Zhao W, Tao T, Zhou YW, Wei L, Li Y, Zheng Y, Zhou GH, Chen H, Zhang J, Feng XB, Wang F, Li N, Zhang XN, Jiang J, Zhu MS. A Shigella sp. variant is causally linked to intractable functional constipation. J Clin Invest. 2022 May 26:e150097. doi: 10.1172/JCI150097.
3. Zheng YY, Wang Y, Chen X, Wei LS, Wang H, Tao T, Zhou YW, Jiang ZH, Qiu TT, Sun ZY, Sun J, Wang P, Zhao W, Li YQ, Chen HQ, Zhu MS, Zhang XN. The thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion. J Biol Chem. 2022 Jan;298(1):101516. doi: 10.1016/j.jbc.2021.101516.
4. Li Y, Zhou Y, Wang P, Tao T, Wei L, Wang Y, Wang W, Zheng Y, Jiang Z, Qiu T, Zhao W, Sun J, Chen X, Zhang XN, Zhu MS. LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle. J Genet Genomics. 2021 Jun 20;48(6):452-462. doi: 10.1016/j.jgg.2021.04.014.
5. Li-sha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li*, Min-Sheng Zhu*, Xuena Zhang* GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. J Biol Chem 2020 in press.
6. Chen X, Yun-Qian Gao, Yan-Yan Zheng, Wei Wang, Pei Wang, Juan Liang, Wei Zhao, Tao Tao, Jie Sun, Li-Sha Wei, Ye-Qiong Li, Yu-Wei Zhou, Zhen-Ji Gan, Xue-Na Zhang, Hua-Qun Chen, Min-Sheng Zhu* Intragenic MIR199A1 in the DNM2 gene contributes to the pathology of X-linked centronuclear myopathy. J Biol Chem 2020 in press.
7. Sun J, Tao T, Zhao W, Wei LS, She F, Wang P, Li Y, Zheng Y, Chen X, Wang W, Qiao YN, Zhang XN, Zhu MS*. CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. J Genet Genomics 2019;46(3):109-118
8. Tao T, Sun J, Peng YJ, Li Y, Wang P, Chen X, Zhao W, Zheng YY, Wei LS, Wang W, Zhou YW, Liu J, Shi YS， Zhu MS* Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. J Biol Chem 2019;294(28):10954-10968
9. Pei Wang, Wei Zhao, Jie Sun, Tao Tao, Xin Chen, Yan-Yan Zheng, Cheng-Hai Zhang, Zhong Chen, Yun-Qian Gao, Fan She, Ye-Qiong Li, Li-Sha Wei, Ping Lu, Cai-Ping Chen, Ji Zhou, Da-Quan Wang, Liang Chen, Xiao-Hao Shi, Linhong Deng, Ronghua ZhuGe, Hua-Qun Chen, Min-Sheng Zhu*.Inflammatory Mediators Mediate Airway Smooth Muscle Contraction through a GPCR-TMEM16A-VDCC Axis and Contribute to Bronchial Hyperresponsiveness in Asthma. J Allergy Clin Immunol 2018;141(4):1259-1268
10. Xu S，Cao S, Zou B, Yue Y, Gu C, Chen X, Wang P, Dong X, Xiang Z, Li K, Zhu MS*, Zhao QS*, Zhou GH* An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome Biology 2016; 17:186-195
11. Zhang CH, Wang P, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Craige SM, Lifshitz LM, Jr KJF, Fogarty KE, ZhuGe R, Zhu MS* The molecular basis underlying the genesis of basal tone in internal anal sphincter. Nature Communication. 2016；7:11358.
12. Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao X, Chen HQ and Zhu MS*. Regulation of DLK1 by the maternally expressed miR-379-544 cluster may underlie Callipyge polar overdominance inheritance. PNAS. 2015; 112(44):13627-32
13. Chen, C.P., Chen, X., Qiao, Y.N., Wang, P., He, W. Q., Zhang, C.H., Zhao, W., Gao, Y.Q., Chen, C., Tao, T., Sun, J., Wang, Y., Gao, N., Kamm, K.E., Stull, J.T., and Zhu, M.S * Roles in vivo for Myosin Phosphatase Targeting Subunit-1 T694 and T852 Phosphorylation sites in Bladder Smooth Muscle. J. Physiology 2015;593(3):681-700 | |||||
承擔科研項目[項目負責人] | |||||
在研項目：
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獲獎情況 | |||||
2016年國家科技進步二等獎（第2完成人）暨教育部科技進步特等獎（第2完成人）一項基因工程小鼠等相關疾病模型研發與應用 | |||||
