作者:2020-09-01浏覽次數:5815

蔣愛芹

研究生導師簡介

姓名

蔣愛芹

研究方向

腫瘤靶向治療研究

聯系方式

Emailjianaq@nju.edu.cn

025-83594757

學術兼職:

中國細胞生物學會會員


個人簡介


1.工作簡曆

2009-至今     伟德官网手机版  講師、副教授

2005-2009年     南京大學分子醫學研究所 講師


2.科研情況簡介

主要從事腫瘤的治療研究。以第一作者或通訊作者身份在SCI收錄雜志上發表論文計20篇。主持國家自然科學基金1項,教育部課題1項,南京大學中央高校項目多項和雙創項目1項。


3.研究興趣:

(1) 天然産物或化學合成來源的抗腫瘤靶向藥物的研究

(2)   三陰性乳腺癌藥物的篩選與作用機制研究


代表性論文[近年通訊作者和第一作者]

1Kai Wang, Ya-Xi Ye, Cheng-Yan Jiang, Meng-Ya Guo, Xiang-Yang Zhang, Ai-Qin Jiang, Yu-Shun Yang, Qing-Cai Jiao, Hai-Liang Zhu. Design and synthesis of a novel "turn-on" fluorescent probe based on benzofuran-3(2H)-one for detection of hydrazine in water samples and biological systems. Dyes and Pigments, 2021,109587. (通訊作者,IF 4.889/Q1)

2Kai Wang, Wei Wang, Xiang-Yang Zhang, Ai-Qin Jiang, Yu-Shun Yang,

Hai-Liang Zhu. Fluorescent probes for the detection of alkaline phosphatase in

biological systems: Recent advances and future prospects. Trends in Analytical Chemistry, 2021, 136: 116189. (通訊作者,IF 12.296/Q1)

3)Ya-Lin Qi, Long Guo, Li-Li Chen, Hua Li, Yu-Shun Yang, Ai-Qin Jiang, Hai-Liang Zhu. Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases. Coordination Chemistry Reviews, 2020, 421: 213460. (通訊作者, IF 22.315/Q1)

4Ya-Liang Zhang, Bo-Yan Li, Rong Yang, Lin-Ying Xia, A-Li Fan, Yi-Chun Chu, Lin-Jian Wang, Zhong-Chang Wang, Ai-Qin Jiang, Hai-Liang Zhu. A class of novel tubulin polymerization inhibitors exert effective antitumor activity via mitotic catastrophe. European Journal of Medicinal Chemistry. 2019, 163, 896-910. (通訊作者, IF 6.514/Q1)

5Ya-Liang Zhang, Rong Yang, Lin-Ying Xia, Ruo-Jun Man, Yi-Chun Chu, Ai-Qin Jiang, Zhong-Chang Wang, Hai-Liang Zhu. Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents. Bioorganic Chemistry 2019, 92: 103219. (通訊作者, IF 5.275/Q3)

6Ruo-Jun Man, Ya-Liang Zhang, Ai-Qin Jiang, Hai-Liang Zhu. A patent review of RAF kinase inhibitors (2010–2018), Expert Opinion on Therapeutic Patents, 2019, 29:675-688.(通訊作者, IF 6.674/Q3

7Chun Xu, Mao Xia, Gang Meng, Chunyan Li, Aiqin Jiang, Jiwu Wei. Carrier Cells for Delivery of Oncolytic Measles Virus into Tumors Determinants of Efficient Loading. Virologica Sinica. 2018, 33:234–240.(通訊作者, IF 4.327/Q4

8Ya-Juan Qin, Yu-jingLia, Ai-Qin Jiang, Meng-RuYangQi-Zhang ZhuHong Dong, Hai-Liang Zhu. Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors. European Journal of Medicinal Chemistry. 2015, 94: 447-457. (通訊作者, IF 6.514/Q1

9Yu-Jia Ren, Zhong-Chang Wang, Xin Zhang, Han-Yue Qiu, Peng-Fei Wang, Ai-Qin Jiang, Hai-Liang Zhu. EGFR/HER-2 inhibitors:synthesis, biological evaluation and analysis of dihydropyridine-containing thiazolinone derivatives. RSC Adv. 2015, 5: 21445-21454. (通訊作者, IF 3.361/Q2

(10) Jin-Hong Liu, Zi-Fei Zhu, Jia Tang, Ai-Qin Jiang, Liu-Fang Hua, Li Chen. Novel NO-releasing derivatives of betulinic acid with antitumor activity. Chinese Chemical Letters, 2015, 26:759–762. (通訊作者, IF 6.779/Q2

(11) Chun yan LiGang MengLei SuAi ping ChenMao XChun XuDecai Yu, Aiqin JiangJi wu WeiDichloroacetate blocks aerobic glycolytic adaptation toattenuated measles virus and promotes viral replication leadingto enhanced oncolysis in glioblastomaOncotarget20156: 1544-1555. (通訊作者)

(12) Aiqin JiangWenbo JinFeng ZhaoZiyong SunJianning LiuSplit Ssp DnaB mini-intein mediated production of recombinant human glucagon-like peptide-1/7-36Biotechnology and Applied Biochemistry201562309-315. (第一作者, IF 2.431

承擔科研項目[項目負責人]

1、南京大學2021雙創科教融合項目 Antimycin-1-PEG-PCL納米顆粒制備及抗三陰性乳腺癌活性研究

2南京大學雙創基地重點項目(0214 1499 9103)新型抗腫瘤生物醫藥研發及産業化平台建設

3、南京大學2020年中央高校重點項目培育計劃 天然産物來源的藥物對三陰性乳腺癌抑制作用的篩選及機制研究

4、國家自然科學青年基金項目(81301943) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究

5、教育部博士點新教師基金(20120091120023)  Sirt6:一個潛在的抑癌基因對腫瘤進行調控的研究

6、中央高校基本科研業務技術創新項目(021414380114) 基于免疫誘導小幹擾RNA的抗腫瘤新藥研發2015/10-2016/10

7、中央高校基本科研業務苗圃項目(021414340243) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究 2014/01-2014/12

8、中央高校基本科研業務苗圃項目 (020620130633) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究2013/01-2013/12

9、中央高校基本科研業務自由探索項目(021414340078) Intein蛋白介導的重組蛋白藥物制備研究




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