研究生導師簡介
姓名 | 蔣愛芹 | 研究方向 | 腫瘤靶向治療研究 | ||
聯系方式 | Email:jianaq@nju.edu.cn 025-83594757 | ||||
學術兼職: 中國細胞生物學會會員 | |||||
個人簡介 | |||||
1.工作簡曆 2009年-至今 伟德官网手机版 講師、副教授 2005年-2009年 南京大學分子醫學研究所 講師 2.科研情況簡介 主要從事腫瘤的治療研究。以第一作者或通訊作者身份在SCI收錄雜志上發表論文計20多篇。主持國家自然科學基金1項,教育部課題1項,南京大學中央高校項目多項和雙創項目1項。 3.研究興趣: (1) 天然産物或化學合成來源的抗腫瘤靶向藥物的研究 (2) 抗三陰性乳腺癌藥物的篩選與作用機制研究 | |||||
代表性論文[近年通訊作者和第一作者] | |||||
(1)Kai Wang, Ya-Xi Ye, Cheng-Yan Jiang, Meng-Ya Guo, Xiang-Yang Zhang, Ai-Qin Jiang, Yu-Shun Yang, Qing-Cai Jiao, Hai-Liang Zhu. Design and synthesis of a novel "turn-on" fluorescent probe based on benzofuran-3(2H)-one for detection of hydrazine in water samples and biological systems. Dyes and Pigments, 2021,109587. (通訊作者,IF 4.889/Q1) (2)Kai Wang, Wei Wang, Xiang-Yang Zhang, Ai-Qin Jiang, Yu-Shun Yang, Hai-Liang Zhu. Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects. Trends in Analytical Chemistry, 2021, 136: 116189. (通訊作者,IF 12.296/Q1) (3)Ya-Lin Qi, Long Guo, Li-Li Chen, Hua Li, Yu-Shun Yang, Ai-Qin Jiang, Hai-Liang Zhu. Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases. Coordination Chemistry Reviews, 2020, 421: 213460. (通訊作者, IF 22.315/Q1) (4)Ya-Liang Zhang, Bo-Yan Li, Rong Yang, Lin-Ying Xia, A-Li Fan, Yi-Chun Chu, Lin-Jian Wang, Zhong-Chang Wang, Ai-Qin Jiang, Hai-Liang Zhu. A class of novel tubulin polymerization inhibitors exert effective antitumor activity via mitotic catastrophe. European Journal of Medicinal Chemistry. 2019, 163, 896-910. (通訊作者, IF 6.514/Q1) (5)Ya-Liang Zhang, Rong Yang, Lin-Ying Xia, Ruo-Jun Man, Yi-Chun Chu, Ai-Qin Jiang, Zhong-Chang Wang, Hai-Liang Zhu. Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents. Bioorganic Chemistry 2019, 92: 103219. (通訊作者, IF 5.275/Q3) (6)Ruo-Jun Man, Ya-Liang Zhang, Ai-Qin Jiang, Hai-Liang Zhu. A patent review of RAF kinase inhibitors (2010–2018), Expert Opinion on Therapeutic Patents, 2019, 29:675-688.(通訊作者, IF 6.674/Q3) (7)Chun Xu, Mao Xia, Gang Meng, Chunyan Li, Aiqin Jiang, Jiwu Wei. Carrier Cells for Delivery of Oncolytic Measles Virus into Tumors Determinants of Efficient Loading. Virologica Sinica. 2018, 33:234–240.(通訊作者, IF 4.327/Q4) (8)Ya-Juan Qin, Yu-jingLia, Ai-Qin Jiang, Meng-RuYang,Qi-Zhang Zhu,Hong Dong, Hai-Liang Zhu. Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors. European Journal of Medicinal Chemistry. 2015, 94: 447-457. (通訊作者, IF 6.514/Q1) (9)Yu-Jia Ren, Zhong-Chang Wang, Xin Zhang, Han-Yue Qiu, Peng-Fei Wang, Ai-Qin Jiang, Hai-Liang Zhu. EGFR/HER-2 inhibitors:synthesis, biological evaluation and analysis of dihydropyridine-containing thiazolinone derivatives. RSC Adv. 2015, 5: 21445-21454. (通訊作者, IF 3.361/Q2) (10) Jin-Hong Liu, Zi-Fei Zhu, Jia Tang, Ai-Qin Jiang, Liu-Fang Hua, Li Chen. Novel NO-releasing derivatives of betulinic acid with antitumor activity. Chinese Chemical Letters, 2015, 26:759–762. (通訊作者, IF 6.779/Q2) (11) Chun yan Li,Gang Meng,Lei Su,Ai ping Chen,Mao X,Chun Xu,Decai Yu, Aiqin Jiang,Ji wu Wei,Dichloroacetate blocks aerobic glycolytic adaptation toattenuated measles virus and promotes viral replication leadingto enhanced oncolysis in glioblastoma,Oncotarget,2015,6: 1544-1555. (通訊作者) (12) Aiqin Jiang,Wenbo Jin,Feng Zhao,Ziyong Sun,Jianning Liu,Split Ssp DnaB mini-intein mediated production of recombinant human glucagon-like peptide-1/7-36,Biotechnology and Applied Biochemistry,2015,62:309-315. (第一作者, IF 2.431) | |||||
承擔科研項目[項目負責人] | |||||
1、南京大學2021雙創科教融合項目 Antimycin-1-PEG-PCL納米顆粒制備及抗三陰性乳腺癌活性研究 2、南京大學雙創基地重點項目(0214 1499 9103)新型抗腫瘤生物醫藥研發及産業化平台建設 3、南京大學2020年中央高校重點項目培育計劃 天然産物來源的藥物對三陰性乳腺癌抑制作用的篩選及機制研究 4、國家自然科學青年基金項目(81301943) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究 5、教育部博士點新教師基金(20120091120023) Sirt6:一個潛在的抑癌基因對腫瘤進行調控的研究 6、中央高校基本科研業務技術創新項目(021414380114) 基于免疫誘導小幹擾RNA的抗腫瘤新藥研發2015/10-2016/10 7、中央高校基本科研業務苗圃項目(021414340243) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究 2014/01-2014/12 8、中央高校基本科研業務苗圃項目 (020620130633) 自噬調控溶瘤麻疹病毒疫苗株複制及溶瘤的機制研究2013/01-2013/12 9、中央高校基本科研業務自由探索項目(021414340078) Intein蛋白介導的重組蛋白藥物制備研究 |