作者：2017-07-03浏覽次數：11814

周正揚

博士研究生導師簡介

姓名

周正揚

研究方向：

1、腫瘤和淋巴結病變的分子和功能MR成像研究

2、自身免疫性疾病的分子和功能MR成像研究

專   業：

影像醫學與核醫學

聯系方式

zyzhou@nju.edu.cn

學術兼職：

中國醫師協會胃腸道腫瘤影像專委會委員；江蘇省中西醫結合影像學分會常務委員；江蘇省放射學會磁共振學組委員

個人簡介

伟德官网手机版附屬鼓樓醫院醫學影像中心行政主任，伟德官网手机版教授，博士生導師。蘇州大學伟德官网手机版碩士，伟德官网手机版博士，美國愛默蕾大學（Emory）伟德官网手机版放射學系訪問教授。近五年主持國家自然科學基金面上項目三項，省部級基金四項；入選江蘇省“六大人才高峰”培養計劃，南京市中青年學科帶頭人；以第一作者/通信作者發表SCI論文65篇，累計影響因子230，其中3篇IF>13、11篇5<IF<10；以第一完成人獲江蘇省醫學三等獎和南京市科學進步三等獎各一項。


研究興趣：

（1）功能MR成像在消化道腫瘤TNM分期和療效評估中的臨床研究

（2）自身免疫性疾病功能MR和分子成像研究

（3）腫瘤及轉移淋巴結的診療一體化研究

代表性論文（第一或通訊作者，IF>3）

  1. Liu S, Shi H, Ji C, Guan W, Chen L, Sun Y, Tang L, Guan Y, Li W, Ge Y, He J, Liu S, Zhou Z.CT textural analysis of gastric cancer: correlations with immunohistochemical biomarkers.Sci Rep. 2018 Aug 7;8(1):11844.        IF:4.122

  2. Meng J, Liu S, Zhu L, Zhu L, Wang H, Xie L, Guan Y, He J, Yang X, Zhou Z. Texture Analysis as Imaging Biomarker for recurrence in advanced cervical cancer treated with CCRT.Sci Rep. 2018 Jul 30;8(1):11399.              IF:4.122

  3. Shi H, Yan R, Wu L, Sun Y, Liu S, Zhou Z, He J, Ye D.Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis.Acta Biomater. 2018 May;72:256-265.       IF: 6.383

  4. Zheng H, Ren W, Pan X, Zhang Q, Liu B, Liu S, He J, Zhou Z. Role of intravoxel incoherent motion MRI in early assessment of the response of esophageal squamous cell carcinoma to chemoradiotherapy: A pilot study.J Magn Reson Imaging. 2018 Jan 3.doi: 10.1002/jmri.25934.IF: 3.612

  5. Liu S, Zheng H, Zhang Y, Chen L, Guan W, Guan Y, Ge Y, He J, Zhou Z. Whole-volume apparent diffusion coefficient-based entropy parameters for assessment of gastric cancer aggressiveness.J Magn Reson Imaging. 2018 Jan;47(1):168-175.      IF: 3.612

  6. Huo D, Liu S, Zhang C, He J, Zhou Z, Zhang H, Hu Y. Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced Radiotherapy.ACS Nano. 2017 Oct 24;11(10):10159-10174.IF: 13.709

  7.  Liu S, Zhang Y, Chen L, Guan W, Guan Y, Ge Y, He J, Zhou Z. Whole-lesion apparent diffusion coefficient histogram analysis: significance in T and N staging of gastric cancers.BMC Cancer. 2017 Oct 2;17(1):665.       IF:3.288

  8. Zhu L, Wang H, Zhu L, Meng J, Xu Y, Liu B, Chen W, He J, Zhou Z, Yang X. Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy.Sci Rep. 2017 Sep 14;7(1):11635.        IF:4.122

  9. Ren S, Cheng X, Chen M, Liu C, Zhao P, Huang W, He J, Zhou Z, Miao L. Hypotoxic and Rapidly Metabolic PEG-PCL-C3-ICG Nanoparticles for Fluorescence-Guided Photothermal/Photodynamic Therapy against OSCC.ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31509-31518.    IF:8.097

  10.  Xu Y, Zhu L, Liu B, Ru T, Wang H, He J, Liu S, Yang X, Zhou Z, Liu T. Strain Elastography Imaging for Early Detection and Prediction of Tumor Response to Concurrent Chemo-Radiotherapy in Locally Advanced Cervical Cancer: Feasibility Study. BMC Cancer2017 Jun 19;17(1):427.IF:3.288

  11.  Hu Y, Cheng H, Zhao X, Wu J, Muhammad F, He J, Zhou L, Zhang C, Deng Y, Wang P, Zhou Z, Nie S, Wei H. Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme Mimicking Activities for Measuring Glucose and Lactate in Living Tissues.  ACS Nano.2017 Jun 27;11(6):5558-5566IF:13.709

  12. Liu S, Liu S, Ji C, Zheng H, Pan X, Zhang Y, Guan W, Chen L, Guan Y, Li W, He J, Ge Y, Zhou Z. Application of CT texture analysis in predicting histopathological characteristics of gastric cancer.  Eur Radiol. 2017 Dec;27(12):4951-4959. IF: 4.027

  13. Chu C, Zhang H, Zhou N, Dou X, Li M, Liu S, Zhu Y, Wang C, Chen W, Chan Q, Sun L, He J, Zhou Z.Diffusional kurtosis imaging of parotid glands in Sjögren's syndrome: Initial findings.J Magn Reson Imaging. 2017 Nov;46(5):1409-1417.     IF: 3.612

  14. Chen B, Chen W, Chan Q, Zhou N, He J, Zhou Z. Functional MRI of human pancreas using BOLD contrast: Responses following glucose ingestion.J Magn Reson Imaging. 2017 Sep;46(3):831-836.          IF: 3.612

  15. Zheng M, Wang Y, Shi H, Hu Y, Feng L, Luo Z, Zhou M, He J, Zhou Z, Zhang Y, Ye D. Redox-Mediated Disassembly to Build Activatable Trimodal Probe for Molecular Imaging of Biothiols.ACS Nano.2016 Nov 22;10(11):10075-10085.        IF: 13.709

  16. Yu H, He J, Lu Q, Huo D, Yuan S, Zhou Z, Xu P, Hu Y. .Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway.ACS Appl Mater Inter. 2016 Nov 9;8(44):29950-29959.    IF:8.097

  17. Zhou N, Chu C, Dou X, Li M, Liu S, Zhu L, Liu B, Guo T, Chen W, He J, Yan J, Zhou Z, Yang X, Liu T. Early evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast-enhanced MR imaging.BMC Cancer. 2016 Nov 8;16(1):865. IF: 3.288

  18. Chu C, Zhou N, Zhang H, Dou X, Li M, Liu S, Zhu Y, Chen W, Chan Q, He J, Sun L, Zhou Z. Use of T1ρMR imaging in Sjögren's syndrome with normal appearing parotid glands: Initial findings.J Magn Reson Imaging. 2017 Apr;45(4):1005-1012.       IF:3.288

  19. Zhang Y, Chen J, Liu S, Shi H, Guan W, Ji C, Guo T, Zheng H, Guan Y, Ge Y, He J, Zhou Z, Yang X, Liu T.Assessment of histological differentiation in gastric cancers using whole-volume histogram analysis of apparent diffusion coefficient maps.J Magn Reson Imaging. 2017 Feb;45(2):440-449.   IF: 3.612

  20. Zhu L, Zhu L, Shi H, Wang H, Yan J, Liu B, Chen W, He J, Zhou Z, Yang X, Liu T. Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging.BMC Cancer. 2016 Feb 10;16:79.   IF: 3.288

  21.  He J, Shi H, Zhou Z, Chen J, Guan W, Wang H, Yu H, Liu S,Zhou Z, Yang X, Liu T.Correlation between apparent diffusion coefficients and HER2 status in g astric cancers: pilot study.BMC Cancer. 2015 Oct 20;15:749.      IF: 3.288

  22.  Yu H, Chen J, Liu S, Lu Q, He J, Zhou Z, Hu Y. Enzyme sensitive, surface engineered nanoparticles for enhanced delivery of camptothecin.J Control Release. 2015 Oct 28;216:111-20.          IF: 7.877

  23.  Liu S, Wang H, Guan W, Pan L, Zhou Z, Yu H, Liu T, Yang X, He J, Zhou Z.Preoperative apparent diffusion coefficient value of gastric cancer by diffusion-weighted imaging: Correlations with postoperative TNM staging.J Magn Reson Imaging. 2015 Sep;42(3):837-43.           IF: 3.612

  24.  Huo D, He J, Li H, Huang AJ, Zhao HY, Ding Y, Zhou ZY, Hu Y.X-ray CT guided fault-free photothermal ablation of metastatic lymph nodes with ultrafine HER-2 targeting W18O49 nanoparticles.Biomaterials. 2014 Nov; 35(33): 9155-66.       IF:8.806

  25.  Huo D, Ding J, Cui YX, Xia LY, Li H, He J, Zhou ZY, Wang HW, Hu Y. X-ray CT and pneumonia inhibition properties of gold-silver nanoparticles for targeting MRSA induced pneumonia.Biomaterials. 2014 Aug;35(25):7032-41.            IF:8.806

  26.  Huo D, He J, Li H, Yu H, Shi T, Feng Y, Zhou Z, Hu Y. Fabrication of Au@Ag core-shell NPs as enhanced CT contrast agents with broad antibacterial properties.Colloid Surface B. 2014 May 1;117:29-35.                IF:3.997


承擔科研課題

  1. 國家自然科學基金面上項目（項目編号：81871410）：熒光導航下雙靶向納米粒子介導的光熱&Tregs清除治療對胃癌轉移淋巴結免疫抑制微環境的調控

  2. 國家自然科學基金面上項目（項目編号：81671751）：胃癌轉移淋巴結微環境響應性診療一體化智能探針構建及術中熒光導航下精準光熱治療

  3. 江蘇省自然科學基金面上項目（項目編号：BK20171118）：胃癌轉移淋巴結微環境響應性診療一體化智能探針的構建及術中熒光導航下光熱治療的實驗研究

  4. 江蘇省省重點研發計劃（項目編号：BE2015605）基于HER-2抗體修飾負載阿黴素的金納米籠粒子對胃癌淋巴結的診療一體化研究。

  5. 國家自然科學基金面上項目（項目編号：81371516）：基于磁性熒光多功能探針USPIO- Cy5.5雙模态成像精确清掃胃癌淋巴結研究

獲獎情況

1、2017年南京市科技進步三等獎（第一完成人）

2、2017年江蘇醫學科技三等獎（第一完成人）



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