作者:2017-07-03浏覽次數:8369

李維勤

博士研究生導師簡介

姓名

李維勤

研究方向:

重症醫學

聯系方式

025-80861658

學術兼職:

全軍重症醫學專業委員會主任委員

中國醫師協會胰腺病分會副主任委員

中華醫學會重症醫學分會常委

江蘇省醫學會重症醫學分會副主任委員

江蘇省醫學會胰腺病分會副主任委員

個人簡介

東部戰區總醫院重症醫學科主任,重症胰腺炎中心主任,伟德官网手机版教授、博士生導師,長江學者特聘教授。

帶領團隊對重症救治技術進行系統的研究,在重症急性胰腺炎的ICU治療、早期腸内營養、微創治療,以及腹腔高壓、腹腔感染、腹腔出血和門靜脈血栓等并發症處理方面積累了豐富經驗,所在的重症胰腺炎中心是目前全國收治轉診病人最多、療效最好的治療中心之一。以第一作者或通訊作者發表SCI文章90餘篇。有關科研成果以第一完成人先後獲得教育部高校科技進步獎二等獎1項、江蘇省科技進步一等獎1項、江蘇省科技進步二等獎1項、軍隊醫療成果二等獎1項和軍隊科技進步二等獎1項。

代表性論文[2年通訊作者或第一作者]

1.Shi XL, Yang Q, Pu N, Li XY, Chen WW, Zhou J, Li G, Tong ZH, Ferec C, Cooper DN et al: Identification and functional characterization of a novel heterozygous missense variant in the LPL associated with recurrent hypertriglyceridemia-induced acute pancreatitis in pregnancy. Molecular genetics & genomic medicine 2020, 8(3):e1048.

2.Li XY, Pu N, Chen WW, Shi XL, Zhang GF, Ke L, Ye B, Tong ZH, Wang YH, Liu G et al: Identification of a novel LPL nonsense variant and further insights into the complex etiology and expression of hypertriglyceridemia-induced acute pancreatitis. Lipids in health and disease 2020, 19(1):63.

3.Xie X, Yuan C, Yin L, Zhu Q, Ma N, Chen W, Ding Y, Xiao W, Gong W, Lu G et al: NQDI-1 protects against acinar cell necrosis in three experimental mouse models of acute pancreatitis. Biochemical and biophysical research communications 2019, 520(1):211-217.

4.Wu J, Ma X, Chen W, Yang N, Gao L, Mao W, Yang J, Yang Q, Dong J, Tong Z et al: Protective effects of HTD4010, a Reg3alpha/PAP-derived peptide, in mouse model of acute pancreatitis via toll-like receptor 4 pathway. Biochemical and biophysical research communications 2019, 512(4):670-677.

5.Mao W, Wu J, Zhang H, Zhou J, Ye B, Li G, Gao L, Li X, Ke L, Tong Z et al: Increase in serum chloride and chloride exposure are associated with acute kidney injury in moderately severe and severe acute pancreatitis patients. Pancreatology : official journal of the International Association of Pancreatology (IAP)  [et al] 2019, 19(1):136-142.

6.Li G, Ke L, Tong Z, Li W, Ouyang X, Chen C: Is it necessary for all patients to use prokinetic agents to place a trans-pyloric tube? Intensive care medicine 2019.

7.Li G, Gao L, Zhou J, Ye B, Zhang J, Qu C, Ke L, Tong Z, Li W: Management of Splenic Abscess after Splenic Arterial Embolization in Severe Acute Pancreatitis: A 5-Year Single-Center Experience. Gastroenterology research and practice 2019, 2019:6069179.

8.Ke L, Mao W, Zhou J, Ye B, Li G, Zhang J, Wang P, Tong Z, Windsor J, Li W: Stent-Assisted Percutaneous Endoscopic Necrosectomy for Infected Pancreatic Necrosis: Technical Report and a Pilot Study. World journal of surgery 2019, 43(4):1121-1128.

9.Gao L, Ke L, Li WQ: Accurate and Dynamic Monitoring of Pancreatic Endocrine Function Is Required in Discharged Patients With Necrotizing Pancreatitis. Gastroenterology 2019, 157(3):892.

10.Fei Y, Li WQ: APnet, an innovative multidisciplinary medical information platform for acute pancreatitis. Revista da Associacao Medica Brasileira (1992) 2019, 65(2):118-122.

11.Chen WW, Yang Q, Li XY, Shi XL, Pu N, Lu GT, Tong ZH, Chen JM, Li WQ: Identification of a novel and heterozygous LMF1 nonsense mutation in an acute pancreatitis patient with severe hypertriglyceridemia, severe obesity and heavy smoking. Lipids in health and disease 2019, 18(1):68.

12.Yong Li YP, 1 Lin Gao,1 Jingzhu Zhang ,1 Xiaochun Xie,1 Zhihui Tong ,1, Baiqiang Li GL, 1 Guotao Lu ,1,2 and Weiqin Li 1: Corrigendum to "Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways". 2018, 2018:8621908.

13.Ye B, Mao W, Chen Y, Tong Z, Li G, Zhou J, Ke L, Li W: Aggressive Resuscitation Is Associated with the Development of Acute Kidney Injury in Acute Pancreatitis. Digestive diseases and sciences 2018.

14.Yang N, Li B, Pan Y, Tu J, Liu G, Lu G, Li W: Hypertriglyceridaemia delays pancreatic regeneration after acute pancreatitis in mice and patients. Gut 2018, 68(2):378-380.

15.Yang N, Ke L, Tong Z, Li W: The effect of thymosin alpha1 for prevention of infection in patients with severe acute pancreatitis. Mediators of inflammation 2018, 18(sup1):53-60.

16.Xing J, Zhang Z, Ke L, Zhou J, Qin B, Liang H, Chen X, Liu W, Liu Z, Ai Y et al: Enteral nutrition feeding in Chinese intensive care units: a cross-sectional study involving 116 hospitals. Critical care (London, England) 2018, 22(1):229.

17.Tu J, Yang Y, Zhang J, Yang Q, Lu G, Li B, Tong Z, Ke L, Li W, Li J: Effect of the disease severity on the risk of developing new-onset diabetes after acute pancreatitis. Medicine (Baltimore) 2018, 97(22):e10713.

18.Liu J, Zou GJ, Yang L, Rong S, Li BQ, Tong ZH, Li WQ, Li JS: Early Prediction of Persistent Organ Failure by Circulating Endothelial Progenitor Cells in Patients With Acute Pancreatitis. Shock (Augusta, Ga) 2018, 50(3):265-272.

19.Li Y, Pan Y, Gao L, Zhang J, Xie X, Tong Z, Li B, Li G, Lu G: Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways. Mediators of inflammation 2018, 2018:3232491.

20.Li Y, Pan Y, Gao L, Lu G, Zhang J, Xie X, Tong Z, Li B, Li G, Li W: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression. Biochemical and biophysical research communications 2018, 495(4):2439-2447.

21.Li X, Yang Q, Shi X, Chen W, Pu N, Li W, Li J: Compound but non-linked heterozygous p.W14X and p.L279 V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. BMC gastroenterology 2018, 17(1):144.

22.Li X, Ke L, Dong J, Ye B, Meng L, Mao W, Yang Q, Li W: Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center. BMC gastroenterology 2018, 18(1):89.

23.Li B, Yang N, Li C, Li C, Gao K, Xie X, Dong X, Yang J, Yang Q, Tong Z et al: INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis. Biochemical and biophysical research communications 2018:1-7.

24.Ke L, Mao W, Li X, Zhou J, Li G, Ye B, Tong Z, Li W: The Pancreatitis Activity Scoring System in Predicting Infection of Pancreatic Necrosis. The American journal of gastroenterology 2018.

25.Gao L, Zhang J: Air Medical Transportation for Severe Acute Pancreatitis Patients over an Extra Long Distance: Is It Safe Enough? 2018, 2018:3826084.

26.Gao L, Lu GT, Lu YY, Xiao WM, Mao WJ, Tong ZH, Yang N, Li BQ, Yang Q, Ding YB et al: Diabetes aggravates acute pancreatitis possibly via activation of NLRP3 inflammasome in db/db mice. American journal of translational research 2018, 10(7):2015-2025.

27.Fei Y, Liu XQ, Gao K, Xue CB, Tang L, Tu JF, Wang W, Li WQ: Analysis of influencing factors of severity in acute pancreatitis using big data mining. 2018, 64(5):454-461.

28.Fei Y, Hu J, Gao K, Tu J, Wang W, Li WQ: Risk Prediction for Portal Vein Thrombosis in Acute Pancreatitis Using Radial Basis Function.Ann Vasc Surg. Annals of vascular surgery 2018, 47:78-84.

29.Fei Y, Gao K, Tu J, Wang W, Zong GQ, Li WQ: Predicting and evaluation the severity in acute pancreatitis using a new modeling built on body mass index and intra-abdominal pressure. American journal of surgery 2018, 216(2):304-309.

30.Fei Y, Gao K, Li WQ: Artificial neural network algorithm model as powerful tool to predict acute lung injury following to severe acute pancreatitis. Revista da Associacao Medica Brasileira (1992) 2018, 18(8):892-899.

31.Fei Y, Gao K, Li WQ: Prediction and evaluation of the severity of acute respiratory distress syndrome following severe acute pancreatitis using an artificial neural network algorithm model. HPB : the official journal of the International Hepato Pancreato Biliary Association 2018.


承擔科研項目[項目負責人]

 2019-2022  “戰時危重傷員重要髒器功能的快速檢測和救治關鍵技術研究”

 全軍後勤科研重大項目            

2018-2020  “全軍急重症救治研究重點實驗室”軍隊後勤科研條件實驗室項目

2018-2020  “現代戰争條件下戰傷救治技術集成研究”全軍十三五重大項目子課題     

2019-2021  “肝髒特異性表達人LPLS447X預防LPL基因缺陷型高甘油三酯血症急性胰腺炎的實驗室研究”國家自然基金面上項目

獲獎情況

201810  “基于人工智能的急性胰腺炎數據挖掘及其并發症輔助診斷的應用”

蘇省醫學新技術引進一等獎(第一完成人)

2017.2    “重症急性胰腺炎救治關鍵技術的創新與應用”

教育部高校科學技術進步獎二等獎(第一完成人)

201310  “創傷感染的代謝改變和特殊營養支持”

獲軍隊科技進步獎二等獎(第一完成人)                           

2009.1  重症急性胰腺炎的實驗和臨床研究”

獲江蘇省科技進步獎一等獎(第一完成人)

2006.2  “重症急性胰腺炎的綜合治療進步”

軍隊醫療成果獎二等獎(第一完成人)

 2000.10  “嚴重腹腔感染病人低蛋白血症的分子機理和防治研究”

獲江蘇省科技進步獎二等獎(第一完成人)



Baidu
sogou