高 千

姓名

高 千

研究方向

疾病分子機制

聯系方式

電話：18795890567

Email：qian_gao@nju.edu.cn

學術兼職：

自然科學基金委重點項目及傑出青年基金評委

江蘇省分子醫學重點實驗室 主任

個人簡介

教授，博士生導師，美國賓夕法尼亞大學伟德官网手机版神經生物學博士，浙江杭州人。

國内完整臨床醫學訓練，先後在美國麻省理工學院和耶魯大學伟德官网手机版做博士後研究。

2004年受聘為耶魯大學伟德官网手机版助理教授，2007年受聘為伟德官网手机版教授。

主要領域為疾病的分子機制及代謝機制研究。

代表性論文[近5年通訊作者和第一作者]

1、Song S, Min H, Niu M, Wang L, Wu Y, Zhang B, Chen X, Liang Q, Wen Y, Wang Y, Yi L, Wang H, Gao Q. S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation. EBioMedicine. 2018 Nov;37:168-176.

2、He X, Chen X, Wang L, Wang W, Liang Q, Yi L, Wang Y, Gao Q. Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux. Life Sci. 2019 Jan 1;216:67-74. doi: 10.1016/j.lfs.2018.09.024.

3、Zhang B, Zhao F, Mao H, Ma W, Zhang Y, Zhang X, Ding J, Gao Q, Wen Y.Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis. Int Immunopharmacol. 2018 Nov;64:208-216.

4、Chen X, Yi L, Song S, Wang L, Liang Q, Wang Y, Wu Y, Gao Q. Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes. Life Sci. 2018 Aug 1;206:84-92.

5、Wen Y, Ding J, Zhang B, Gao Q. Bone marrow-derived mononuclear cell therapy for nonischaemic dilated cardiomyopathy-A meta-analysis.Eur J Clin Invest. 2018 Apr;48(4).

6、Chen X, Wang L, Fan S, Song S, Min H, Wu Y, He X, Liang Q, Wang Y, Yi L, Gao Q. Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor. Eur J Pharmacol. 2018 Jan 5;818:115-123.

7、Chen X, Wang L, Wu Y, Song S, Min H, Yan Y, He X, Liang Q, Yi L, Wang Y, Gao Q. Effect of Puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats.Nutrition＆Diabetes. Diabetes. 2018 Jan 12;8(1):1.

8、Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J.The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening. Int J Nanomedicine. 2017; 12: 3617–3636.

9、Song S, Su Z, Xu H, Niu M, Chen X, Min H, Zhang B, Sun G, Xie S, Wang H, Gao Q. Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. Cell Death Dis. 2017 Feb; 8(2): e2612..

10、Min H, Fan S, Song S, Zhuang Y, Li H, Wu Y, Cai H, Yi L, Dai J, Gao Q. Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis. Diagn Pathol. 2016;23;11:135.

11、Deng Z, Wang Z, Jin J, Wang Y, Bao N, Gao Q, Zhao J. SIRT1 Protects Osteoblasts against Particle-induced Inflammatory Responses and Apoptosis in Aseptic Prosthesis Loosening. Acta Biomater. 2016 Nov 23.

12、Zhang X, Ma D, Zou W, Ding Y, Zhu C, Min H, Zhang B, Wang W, Chen B, Ye M, Cai M, Pan Y, Cao L, Wan Y, Jin Y, Gao Q, Yi L. A rapid NGS strategy forcomprehensive molecular diagnosis of Birt-Hogg-Dub syndrome in patients with primary spontaneous pneumothorax. Respir Res. 2016 May 27;17(1):64.

13、Xia Y, Wang W, Wang L, Shen S, Cao Y, Yi L, Gao Q, Wang Y. hOGG1 gene polymorphisms and susceptibility to polycystic ovary syndrome. Biomed Rep. 2016 Apr;4(4):421-426.

14、Zhang B, Xie S, Su Z, Song S, Xu H, Chen G, Cao W, Yin S, Gao Q, Wang H. Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling. Sci Rep. 2016 Feb 19;6:21132.

15、Yang Y, Chen X, Min H, Song S, Zhang J, Fan S, Yi L, Wang H, Gu X, Ma Z, Gao Q. Persistent mitoK(ATP) Activation Is Involved in the Isoflurane-induced Cytotoxicity. Mol Neurobiol. 2016 Jan 23.

16、Yang Y, Song S, Min H, Chen X, Gao Q. STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. Neuroreport. 2016 Jan20;27(2):124-30.

17、Huang X, Jin J, Shen S, Xia Y, Xu P, Zou X, Wang H, Yi L, Wang Y, Gao Q.Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line. Gynecol Endocrinol. 2016;32(3):201-5.

18、Min H, Ding J, Wen Y, Ma X, Gao Q. Combinatorial Treatment of Bone Marrow Transplantation and Regulatory T Cells Improves Glycemia in Streptozotocin-diabetic Mice. Exp Clin Endocrinol Diabetes. 2015;123:638-44.

19、Ding Y, Zou W, Zhu C, Min H, Ma D, Chen B, Ye M, Pan Y, Cao L, Wan Y, Zhu Q, Xia H, Zhang W, Feng Y, Gao Q, Yi L. Promoter methylation is not associated with FLCN irregulation in lung cyst lesions of primary spontaneous pneumothorax. Mol Med Rep. 2015 Nov;12(5):7770-6.

20、Zhang X, Wang T, Wang W, Ding Y, Zhou L, Chen Q, Gao X, Wu Y, Mei Y, Jin Y, Gao Q, Yi L. Does familial breast cancer and thymoma suggest a cancer syndrome? A family perspective. Gene. 2015 Dec 1;573(2):333-7.

21、Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y, Wang W, Wu X, Wang H, Yi L, Gao Q, Wang Y. The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res. 2015 Mar 22;8:11.

22、Ding Y, Zhu C, Zou W, Ma D, Min H, Chen B, Ye M, Pan Y, Cao L, Wan Y, Zhang W, Meng L, Mei Y, Yang C, Chen S, Gao Q, Yi L. FLCN intragenic deletions in Chinese familial primary spontaneous pneumothorax. Am J Med Genet A. 2015May;167A(5):1125-33.

23、Xie S, Su Z, Zhang B, Ge J, Song S, Sun G, Sun X, Yi L, Wang Y, Sun W, Wang H, Gao Q. SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice. J Invest Dermatol. 2015 Jul;135(7):1915-8.

24、Ding Y, Yang M, She S, Min H, Xv X, Ran X, Wu Y, Wang W, Wang L, Yi L, Yang Y, Gao Q. iTRAQ-based quantitative proteomic analysis of cervical cancer. Int J Oncol. 2015 Apr;46(4):1748-58.

25、Dai J, Cai H, Zhuang Y, Wu Y, Min H, Li J, Shi Y, Gao Q, Yi L. Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population. Respirology. 2015 Jan;20(1):122-8.

26、Zhang W, Shen L, Deng Z, Ding Y, Mo X, Xu Z, Gao Q, Yi L. Novel missense variants of ZFPM2/FOG2 identified in conotruncal heart defect patients do not impair interaction with GATA4. PLoS One. 2014 Jul 15;9(7):e102379.

27、Wen Y, Xu J, Ma X, Gao Q. High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. Am J Cardiovasc Drugs. 2013 Dec;13(6):435-42.

28、Ma X, Ding J, Min H, Wen Y, Gao Q. Protective role of low-dose TGF-b 1 in early diabetic nephropathy induced by streptozotocin. Int Immunopharmacol. 2013 Nov;17(3):752-8.

29、Zhang X, Zhang C, Shen S, Xia Yj, Yi L, Gao Q, Wang Y. Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Hum Reprod. 2013 Nov;28(11):3074-85.

30、Xu P, Shen SM, Zhang XL, Liang F, Xie GB, Yi L, Gao Q, Wang Y. Haplotype analysis of single nucleotide polymorphisms in anti-M llerian hormone gene in Chinese PCOS women. Arch Gynecol Obstet. 2013 Jul;288(1):125-30.

31、Zhang X, Su Z, Zhang X, Hu C, Yu J, Gao Q, Wang H. Generation of Mycobacterium tuberculosis-specific recombinant antigens and evaluation of the clinical value of antibody detection for serological diagnosis of pulmonary tuberculosis. Int J Mol Med. 2013 Mar;31(3):751-7.

32、Xie GB, Xu P, Che YN, Xia YJ, Cao YX, Wang WJ, Qiao D, Wu XK, Yi L, Gao Q, Wang Y. Microsatellite polymorphism in the fibrillin 3 gene and susceptibility to PCOS: a case-control study and meta-analysis. Reprod Biomed Online. 2013 Feb;26(2):168-74.

承擔科研項目[項目負責人]

銀屑病代謝綜合征共同免疫機制研究，國家自然科學基金（81570775），2016-2019，68萬元，課題負責人；

獲獎情況

N/A