作者：2017-07-03浏覽次數：24283

侯亞義

博士研究生導師簡介

姓名

侯亞義

研究方向：

細胞與分子免疫

聯系方式

電話：025-83686341

Email：yayihou@nju.edu.cn

學術兼職：曾為江蘇省免疫學會常務理事等。

個人簡介

侯亞義，南京大學教授/博導。獲南京大學理學學士和碩士學位，日本東京大學博士學位。曾在東京大學從事博士後研究和美國密西根大學伟德官网手机版作為訪問學者。探索了炎症微環境中髓系免疫細胞調控腫瘤/自身免疫病發生發展的分子機制，發現髓源抑制性細胞（MDSCs）的異常擴增發生在狼瘡的早期及其對T細胞等的調控作用；分析了樹突狀細胞（DCs）及間充質幹細胞（MSCs）在自身免疫病中的作用，發現MSCs産生的外泌體與其母細胞對于緩解炎症性及免疫性疾病的作用類似；研究了腫瘤免疫逃逸機制，建立了一些靶向治療腫瘤的方法；評價了一些中藥成分對小鼠疾病模型的免疫調節及纖維化緩解的效果。主持和參與過國家自然科學基金重大研究計劃項目、國家科技部重點研發計劃課題、國家科技重大專項、國家科技支撐計劃重大項目、江蘇省衛生廳“興衛工程”等項目。發表國内外論文280餘篇，其中SCI收錄論文220餘篇；獲授權國家專利5件。

代表性論文[近3年通訊作者和第一作者]

  1. Li D, Lu L, Kong W, Xia X, Pan Y, Li J, Wang J, Wang T, Liang J, Dou H, Hou Y. C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1 + M-MDSCs in relieving lupus-like symptoms. Cell Death Dis. 2021 Sep 3;12(9):829.

  2. Shi G, Li D, Zhang D, Xu Y, Pan Y, Lu L, Li J, Xia X, Dou H, Hou Y. IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development. Cell Death Discov. 2021 Jul 16;7(1):179.

  3. Wang J, Li D, Pan Y, Li J, Jiang Q, Liu D, Hou Y. Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1+monocytes/macrophages. Eur J Immunol. 2021 Jun 17. doi: 10.1002/eji.202149174.

  4. Liu D, Li Q, Ding H, Zhao G, Wang Z, Cao C, Dai Y, Zheng M, Zhu X, Wu Q, Wang Y, Duan H, Tang H, Lu X, Hou Y, Hu Y. Placenta-derived IL-32β activates neutrophils to promote preeclampsia development. Cell Mol Immunol. 2021 Apr;18(4):979-991. 

  5. Li Y, Xu Y, Liu X, Yan X, Lin Y, Tan Q, Hou Y. mTOR inhibitor INK128 promotes wound healing by regulating MDSCs. Stem Cell Res Ther. 2021 Mar 10;12(1):170. 

  6. Zhang D, Song Y, Li D, Liu X, Pan Y, Ding L, Shi G, Wang Y, Ni Y, Hou Y. Cancer-associated fibroblasts promote tumor progression by lncRNA-mediated RUNX2/GDF10 signaling in oral squamous cell carcinoma. Mol Oncol. 2021 Mar 3. doi: 10.1002/1878-0261.12935.

  7. Sun Z, Qu J, Xia X, Pan Y, Liu X, Liang H, Dou H, Hou Y. 17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis. Int J Biol Sci. 2021 Jan 1;17(2):460-474.  

  8. Li J, Pan Y, Li D, Xia X, Jiang Q, Dou H, Hou Y. Urokinase-type plasminogen activator receptor is required for impairing toll-like receptor 7 signaling on macrophage efferocytosis in lupus. Mol Immunol. 2020 Nov;127: 38-45. 

  9. Sun Z, Pan Y, Qu J, Xu Y, Dou H, Hou Y. 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Front Immunol. 2020 Jul 22; 11:1591.

  10. Li D, Pan Y, Xia X, Liang J, Liu F, Dou H, Hou Y. Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells. Eur J Pharmacol. 2020 Oct 5; 884:173421.

  11. Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y. Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.  Am J Transl Res. 2020 Jun 15; 12(6):2675-2684. 

  12. Yao G, Qi J, Liang J, Shi B, Chen W, Li W, Tang X, Wang D, Lu L, Chen W, Shi S, Hou Y, Sun L. Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis. Theranostics. 2019 Oct 21;9(26):8253-8265.

  13. Xu Y, Li Y, Liu X, Pan Y, Sun Z, Xue Y, Wang T, Dou H, Hou Y. SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1/HES1-mediated autophagy. Int J Nanomedicine. 2019 Aug 23; 14:6779-6797.

  14. Ji J, Ren L, Liu Y, Zheng M, Fang H, Xu Hui, He H, Zhang M, Wang X, Shan J, Hou Y. Elevated monocytic-myeloid derived suppressor cells positively correlate with infection frequency in children with RRTIs. Eur J Immunol. 2020 Oct 27. doi: 10.1002/eji.202048629. 

  15. Sun Z, Pan Y, Qu J, Xu Y, Dou H, Hou Y. 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB. Front Immunol. 11:1591, 2020.

  16. Li D, Pan Y, Xia X, Liang J, Liu F, Dou H, Hou Y. Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells.Eur J Pharmacol. 884:173421, 2020.

  17. Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y. Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.Am J Transl Res. 12(6):2675-2684, 2020.

  18. Yao G, Qi J, Liang J, Shi B, Chen W, Li W, Tang X, Wang D, Lu L, Chen W, Shi S, Hou Y, Sun L. Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis. Theranostics. 2019 Oct 21;9(26):8253-8265.

  19. Xu Y, Li Y, Liu X, Pan Y, Sun Z, Xue Y, Wang T, Dou H, Hou Y. SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1/HES1-mediated autophagy. Int J Nanomedicine. 2019 Aug 23; 14:6779-6797.

  20. Ji J, Li P, Shen C, Dou H, Wang T, Shi L, Hou Y. MDSCs: friend or foe in systemic lupus erythematosus. Cell Mol Immunol. 2019 Dec;16(12):937-939.

  21. Li D, Qi J, Wang J, Pan Y, Li J, Xia X, Dou H, Hou Y. Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway. Free Radic Biol Med. 2019 Nov 1; 143:260-274.

  22. Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H, Hou Y. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res Ther. 2019 Apr 25;21(1):105.

  23. Shi G, Li D, Li X, Ren J, Xu J, Ding L, Dou H, Hou Y. mTOR inhibitor INK128attenuates systemic lupus erythematosus by regulating inflammation inducedCD11b (+) Gr1(+) cells. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):1-13.

  24. Zhao J, Zhang Z, Xue Y, Wang G, Cheng Y, Pan Y, Zhao S, Hou Y. Anti-tumor macrophages activated by ferumoxytolcombined or surface-functionalized with the TLR3agonist poly (I:C) promote melanoma regression.  Theranostics, 2018; 8(22): 6307-6321.

  25. Pan Y, Wang J, Xue Y, Zhao J, Li D, Zhang S, Li K, Hou Y, Fan H. GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a. Front Immunol. 2018 Oct 2; 9:2272.

  26. Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, Wang Y, Wang T, Hou Y.Carcinoma-associated fibroblasts promote the stemness and chemoresistance ofcolorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018 Jun24;8(14):3932-3948.

  27. Zhang D, Xu J, Ren J, Ding L, Shi G, Li D, Dou H, Hou Y. Myeloid-DerivedSuppressor Cells Induce Podocyte Injury Through Increasing Reactive OxygenSpecies in Lupus Nephritis. Front Immunol. 2018 Jun 25;9:1443.

  28. Ding L, Ren J, Zhang D, Li Y, Huang X, Hu Q, Wang H, Song Y, Ni Y, Hou Y. Anovel stromal lncRNA signature reprograms fibroblasts to promote the growth oforal squamous cell carcinoma via LncRNA-CAF/interleukin-33. Carcinogenesis. 2018 Mar 8;39(3):397-406.

  29. Ren J, Hou Y, Wang T. Roles of estrogens on myeloid-derived suppressor cellsin cancer and autoimmune diseases. Cell Mol Immunol. 2018 Jul;15(7):724-726.

  30. Fan H, Ren D, Hou Y. TLR7, a third signal for the robust generation ofspontaneous germinal center B cells in systemic lupus erythematosus. Cell MolImmunol. 2018 Mar;15(3):286-288.

目前承擔科研項目[項目負責人]

  1. 狼瘡病程中TLR7信号通過Dectin-3/CARD9軸調控MDSCs數量及功能的機制。（國家自然科學基金資助項目(31872732)，2019.01- 2022.12）。主持

  2. 間充質幹細胞通過調控髓系免疫細胞炎症參與子宮内膜重建的新技術研發。（江蘇省重點研發計劃（社會發展）臨床前沿項目（BE2019706），2019.7-2022.6）。主持

  3. Toll樣受體激動劑在卵巢癌分子靶向精準診治中的技術開發與應用研究。（江蘇省重點研發計劃（社會發展）臨床前沿項目（BE2019617），2019.7-2022.6）。合作參與


獲獎情況

2005年度國家科學技術科技進步二等獎；

2007年度江蘇省科技進步獎三等獎；

2014年度江蘇省科技進步獎一等獎；

2016年獲江蘇省高校科學技術研究獎二等獎；

2017年度江蘇省科技進步獎一等獎。



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